{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:57:06Z","timestamp":1790009826084,"version":"4.0.1"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2019,7,16]]},"DOI":"10.1001\/jama.2019.9021","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:02:20Z","timestamp":1563274940000},"page":"240","source":"Crossref","is-referenced-by-count":130,"title":["Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis"],"prefix":"10.1001","volume":"322","author":[{"given":"Jeremy M.","family":"Kahn","sequence":"first","affiliation":[{"name":"CRISMA Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie S.","family":"Davis","sequence":"additional","affiliation":[{"name":"CRISMA Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Yabes","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Chou H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Chong","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Batra","family":"Hershey","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Martsolf","sequence":"additional","affiliation":[{"name":"Department of Acute and Tertiary Care, School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"RAND Corporation, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek C.","family":"Angus","sequence":"additional","affiliation":[{"name":"CRISMA Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"8","key":"joi190067r1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third internatonal consensus definitions for sepsis and septic shock (Sepsis-3).","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"2","key":"joi190067r2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"issue":"2","key":"joi190067r3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s00134-009-1738-3","article-title":"The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis.","volume":"36","author":"Levy","year":"2010","journal-title":"Intensive Care Med"},{"issue":"1","key":"joi190067r4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/CCM.0000000000000723","article-title":"Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study.","volume":"43","author":"Levy","year":"2015","journal-title":"Crit Care Med"},{"issue":"9","key":"joi190067r5","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1007\/s00134-015-3906-y","article-title":"The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study).","volume":"41","author":"Rhodes","year":"2015","journal-title":"Intensive Care Med"},{"issue":"14","key":"joi190067r6","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1001\/jama.2014.11350","article-title":"Sepsis mandates: improving inpatient care while advancing quality improvement.","volume":"312","author":"Cooke","year":"2014","journal-title":"JAMA"},{"issue":"24","key":"joi190067r7","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1056\/NEJMp1611928","article-title":"State sepsis mandates\u2014a new era for regulation of hospital quality.","volume":"376","author":"Hershey","year":"2017","journal-title":"N Engl J Med"},{"issue":"23","key":"joi190067r8","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to treatment and mortality during mandated emergency care for sepsis.","volume":"376","author":"Seymour","year":"2017","journal-title":"N Engl J Med"},{"issue":"7","key":"joi190067r9","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1164\/rccm.201609-1848OC","article-title":"The timing of early antibiotics and hospital mortality in sepsis.","volume":"196","author":"Liu","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"18","key":"joi190067r10","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock.","volume":"370","author":"Yealy","year":"2014","journal-title":"N Engl J Med"},{"issue":"18","key":"joi190067r11","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1056\/NEJMp1400276","article-title":"Regulatory mandates for sepsis care\u2014reasons for caution.","volume":"370","author":"Rhee","year":"2014","journal-title":"N Engl J Med"},{"issue":"22","key":"joi190067r12","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1001\/jama.2014.16153","article-title":"Methods for evaluating changes in health care policy: the difference-in-differences approach.","volume":"312","author":"Dimick","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"joi190067r14","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","article-title":"Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.","volume":"35","author":"Dombrovskiy","year":"2007","journal-title":"Crit Care Med"},{"issue":"6","key":"joi190067r15","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1097\/MLR.0b013e318268ac86","article-title":"Identifying patients with severe sepsis using administrative claims: patient-level validation of the angus implementation of the international consensus conference definition of severe sepsis.","volume":"52","author":"Iwashyna","year":"2014","journal-title":"Med Care"},{"issue":"5","key":"joi190067r16","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/CCM.0000000000003005","article-title":"Reporting of sepsis cases for performance measurement versus for reimbursement in New York State.","volume":"46","author":"Prescott","year":"2018","journal-title":"Crit Care Med"},{"issue":"9","key":"joi190067r17","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s00134-015-3822-1","article-title":"A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators.","volume":"41","author":"Angus","year":"2015","journal-title":"Intensive Care Med"},{"issue":"23","key":"joi190067r18","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1056\/NEJMoa1701380","article-title":"Early, goal-directed therapy for septic shock\u2014a patient-level meta-analysis.","volume":"376","author":"Rowan","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"joi190067r19","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12913-019-4037-x","article-title":"An administrative model for benchmarking hospitals on their 30-day sepsis mortality.","volume":"19","author":"Darby","year":"2019","journal-title":"BMC Health Serv Res"},{"issue":"4","key":"joi190067r20","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1097\/CCM.0000000000000858","article-title":"Derivation and validation of the acute organ failure score to predict outcome in critically ill patients: a cohort study.","volume":"43","author":"Elias","year":"2015","journal-title":"Crit Care Med"},{"issue":"5","key":"joi190067r21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/PCC.0000000000001502","article-title":"Hospital variation in risk-adjusted pediatric sepsis mortality.","volume":"19","author":"Ames","year":"2018","journal-title":"Pediatr Crit Care Med"},{"issue":"11","key":"joi190067r22","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data.","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care"},{"issue":"24","key":"joi190067r23","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1001\/jama.2010.851","article-title":"Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis.","volume":"303","author":"Mayr","year":"2010","journal-title":"JAMA"},{"issue":"1","key":"joi190067r24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/0034-6527.00321","article-title":"Semiparametric difference-in-differences estimators.","volume":"72","author":"Abadie","year":"2005","journal-title":"Rev Econ Stud"},{"issue":"1","key":"joi190067r25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1257\/jel.47.1.5","article-title":"Recent developments in the econometrics of program evaluation.","volume":"47","author":"Imbens","year":"2009","journal-title":"J Econ Lit"},{"issue":"3","key":"joi190067r26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1177\/0193841X16663414","article-title":"The validity of the comparative interrupted time series design for evaluating the effect of school-level interventions.","volume":"40","author":"Jacob","year":"2016","journal-title":"Eval Rev"},{"issue":"3","key":"joi190067r27","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3102\/1076998616636854","article-title":"The validity and precision of the comparative interrupted time-series design: three within-study comparisons.","volume":"41","author":"St Clair","year":"2016","journal-title":"J Educ Behav Stat"},{"issue":"2","key":"joi190067r28","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/01.CCM.0000253405.17038.43","article-title":"Seasonal variation in the epidemiology of sepsis.","volume":"35","author":"Danai","year":"2007","journal-title":"Crit Care Med"},{"issue":"13","key":"joi190067r29","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012.","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"issue":"11","key":"joi190067r31","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1164\/rccm.201712-2545OC","article-title":"Mortality changes associated with mandated public reporting for sepsis: results of the New York State initiative.","volume":"198","author":"Levy","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"13","key":"joi190067r32","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014.","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"issue":"8","key":"joi190067r33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1001\/jama.2012.9502","article-title":"The value of statistical analysis plans in observational research: defining high-quality research from the start.","volume":"308","author":"Thomas","year":"2012","journal-title":"JAMA"},{"key":"joi190067r13","unstructured":"KahnJM. Quantitative evaluation of the effects the 2013 New York State sepsis regulations. https:\/\/osf.io\/jcwdv\/. Accessed May 18, 2018."},{"key":"joi190067r30","unstructured":"Greater New York Hospital Association. STOP sepsis. https:\/\/www.gnyha.org\/topic\/sepsis\/. Accessed May 18, 2018."}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jama\/article-pdf\/322\/3\/240\/17724679\/jama_kahn_2019_oi_190067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:02:25Z","timestamp":1563274945000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2019.9021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,16]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7,16]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.9021","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,16]]}}}