{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:57:56Z","timestamp":1792105076759,"version":"4.4.0"},"reference-count":78,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2019,7,9]]},"DOI":"10.1001\/jama.2019.9052","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T11:38:13Z","timestamp":1562672293000},"page":"153","source":"Crossref","is-referenced-by-count":551,"title":["Subclinical Hypothyroidism"],"prefix":"10.1001","volume":"322","author":[{"given":"Bernadette","family":"Biondi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne R.","family":"Cappola","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, the University of Pennsylvania, Philadelphia"},{"name":"Associate Editor, JAMA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"9821","key":"jrv190006r1","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/S0140-6736(11)60276-6","article-title":"Subclinical thyroid disease.","volume":"379","author":"Cooper","year":"2012","journal-title":"Lancet"},{"issue":"4","key":"jrv190006r2","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"The Colorado thyroid disease prevalence study.","volume":"160","author":"Canaris","year":"2000","journal-title":"Arch Intern Med"},{"issue":"2","key":"jrv190006r3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994).","volume":"87","author":"Hollowell","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"jrv190006r4","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1210\/jc.2011-3047","article-title":"The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study.","volume":"97","author":"Somwaru","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"jrv190006r5","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1210\/jc.2007-1499","article-title":"Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population.","volume":"92","author":"Surks","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"jrv190006r6","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1210\/jc.2011-3020","article-title":"Age-related changes in thyroid function.","volume":"97","author":"Bremner","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"jrv190006r7","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1210\/jc.2012-2481","article-title":"Longitudinal changes in thyroid function in the oldest old and survival.","volume":"97","author":"Waring","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"jrv190006r8","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1210\/jcem.87.3.8165","article-title":"Narrow individual variations in serum T(4) and T(3) in normal subjects.","volume":"87","author":"Andersen","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"jrv190006r9","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1210\/jc.2003-031641","article-title":"Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins.","volume":"89","author":"Hansen","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"26","key":"jrv190006r10","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1056\/NEJMcp1611144","article-title":"Subclinical Hypothyroidism.","volume":"376","author":"Peeters","year":"2017","journal-title":"N Engl J Med"},{"issue":"12","key":"jrv190006r11","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1001\/jama.2010.1361","article-title":"Subclinical hypothyroidism and the risk of coronary heart disease and mortality.","volume":"304","author":"Rodondi","year":"2010","journal-title":"JAMA"},{"issue":"20","key":"jrv190006r12","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1001\/jama.2015.5161","article-title":"Subclinical thyroid dysfunction and fracture risk.","volume":"313","author":"Blum","year":"2015","journal-title":"JAMA"},{"issue":"3","key":"jrv190006r13","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum.","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"issue":"21","key":"jrv190006r14","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1001\/jama.292.21.2591","article-title":"Thyroid status, disability and cognitive function, and survival in old age.","volume":"292","author":"Gussekloo","year":"2004","journal-title":"JAMA"},{"issue":"21","key":"jrv190006r15","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1001\/archinternmed.2009.392","article-title":"Subclinical hypothyroidism and functional mobility in older adults.","volume":"169","author":"Simonsick","year":"2009","journal-title":"Arch Intern Med"},{"issue":"11","key":"jrv190006r16","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1210\/jc.2016-1935","article-title":"Serum thyroid function, mortality and disability in advanced old age.","volume":"101","author":"Pearce","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"jrv190006r17","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/cen.2007.67.issue-5","article-title":"Identification of TSH receptor mutations in three families with resistance to TSH.","volume":"67","author":"Tonacchera","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"jrv190006r18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.soard.2007.07.011","article-title":"Influence of obesity and surgical weight loss on thyroid hormone levels.","volume":"3","author":"Chikunguwo","year":"2007","journal-title":"Surg Obes Relat Dis"},{"issue":"11","key":"jrv190006r19","doi-asserted-by":"publisher","first-page":"6185","DOI":"10.1210\/jc.2005-0003","article-title":"Spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating leptin in obese premenopausal women.","volume":"90","author":"Kok","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"jrv190006r20","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1530\/EJE-14-0067","article-title":"Mechanisms in endocrinology crosstalk between thyroid gland and adipose tissue.","volume":"171","author":"Santini","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"jrv190006r21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1210\/jcem-62-4-717","article-title":"Relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness.","volume":"62","author":"Hamblin","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"jrv190006r22","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/clinchem\/33.8.1391","article-title":"Specificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients.","volume":"33","author":"Spencer","year":"1987","journal-title":"Clin Chem"},{"issue":"1","key":"jrv190006r23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jss.2014.07.003","article-title":"Prediction of thyroid hormone supplementation after thyroid lobectomy.","volume":"193","author":"Lee","year":"2015","journal-title":"J Surg Res"},{"issue":"4","key":"jrv190006r24","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1210\/jc.2016-3597","article-title":"Clinical features of early and late postoperative hypothyroidism after lobectomy.","volume":"102","author":"Park","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"jrv190006r25","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.beem.2013.10.003","article-title":"Pitfalls in the measurement and interpretation of thyroid function tests.","volume":"27","author":"Koulouri","year":"2013","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"6","key":"jrv190006r26","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/cen.12643","article-title":"Macro TSH in patients with subclinical hypothyroidism.","volume":"83","author":"Hattori","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"14","key":"jrv190006r27","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1001\/archinte.167.14.1533","article-title":"Serum thyrotropin measurements in the community.","volume":"167","author":"Meyerovitch","year":"2007","journal-title":"Arch Intern Med"},{"issue":"1","key":"jrv190006r28","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1210\/er.2006-0043","article-title":"The clinical significance of subclinical thyroid dysfunction.","volume":"29","author":"Biondi","year":"2008","journal-title":"Endocr Rev"},{"issue":"10","key":"jrv190006r29","doi-asserted-by":"publisher","first-page":"4890","DOI":"10.1210\/jc.2003-032061","article-title":"Spontaneous subclinical hypothyroidism in patients older than 55 years.","volume":"89","author":"D\u00edez","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"jrv190006r30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","article-title":"The incidence of thyroid disorders in the community.","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"jrv190006r31","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1210\/jc.2005-0375","article-title":"Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism.","volume":"90","author":"D\u00edez","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"jrv190006r32","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1210\/jc.2007-2368","article-title":"Antithyroperoxidase and antithyroglobulin antibodies in a five-year follow-up survey of populations with different iodine intakes.","volume":"93","author":"Li","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"jrv190006r33","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1210\/jc.2009-1977","article-title":"Thyrotropin and thyroid antibodies as predictors of hypothyroidism.","volume":"95","author":"Walsh","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"jrv190006r34","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1046\/j.1525-1497.1997.07109.x","article-title":"Do traditional symptoms of hypothyroidism correlate with biochemical disease?","volume":"12","author":"Canaris","year":"1997","journal-title":"J Gen Intern Med"},{"issue":"9","key":"jrv190006r35","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1089\/thy.2013.0017","article-title":"Thyroid hormone status and health-related quality of life in the LifeLines Cohort Study.","volume":"23","author":"Klaver","year":"2013","journal-title":"Thyroid"},{"issue":"10","key":"jrv190006r36","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1210\/jc.2008-2702","article-title":"Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism.","volume":"94","author":"Correia","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3-4","key":"jrv190006r37","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1159\/000437387","article-title":"Subclinical thyroid dysfunction and depressive symptoms among the elderly.","volume":"103","author":"Blum","year":"2016","journal-title":"Neuroendocrinology"},{"issue":"5","key":"jrv190006r38","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1210\/jc.2017-01247","article-title":"Subclinical hypothyroidism and incident depression in young and middle-age adults.","volume":"103","author":"Kim","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"jrv190006r39","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.amjmed.2016.06.013","article-title":"Hypothyroid symptoms fail to predict thyroid insufficiency in old people.","volume":"129","author":"Carl\u00e9","year":"2016","journal-title":"Am J Med"},{"issue":"26","key":"jrv190006r40","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1056\/NEJMoa1603825","article-title":"Thyroid hormone therapy for older adults with subclinical hypothyroidism.","volume":"376","author":"Stott","year":"2017","journal-title":"N Engl J Med"},{"issue":"11","key":"jrv190006r41","doi-asserted-by":"publisher","first-page":"904","DOI":"10.7326\/0003-4819-137-11-200212030-00011","article-title":"Effects of subclinical thyroid dysfunction on the heart.","volume":"137","author":"Biondi","year":"2002","journal-title":"Ann Intern Med"},{"issue":"1","key":"jrv190006r42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jjcc.2012.08.017","article-title":"Evaluation of left ventricular diastolic function using tissue Doppler echocardiography and conventional doppler echocardiography in patients with subclinical hypothyroidism aged &lt;60 years.","volume":"61","author":"Chen","year":"2013","journal-title":"J Cardiol"},{"issue":"6","key":"jrv190006r43","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1089\/thy.2007.0051","article-title":"Thyroid disease and vascular function.","volume":"17","author":"Owen","year":"2007","journal-title":"Thyroid"},{"issue":"25","key":"jrv190006r44","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1161\/01.cir.0000437738.63853.7a","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults.","volume":"129","author":"Stone","year":"2014","journal-title":"Circulation"},{"issue":"6","key":"jrv190006r45","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.dsx.2018.05.002","article-title":"Direct correlation between serum homocysteine level and insulin resistance index in patients with subclinical hypothyroidism.","volume":"12","author":"Ebrahimpour","year":"2018","journal-title":"Diabetes Metab Syndr"},{"key":"jrv190006r46","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.12659\/MSM.891163","article-title":"Alteration of lipid profile in subclinical hypothyroidism.","volume":"20","author":"Liu","year":"2014","journal-title":"Med Sci Monit"},{"issue":"10","key":"jrv190006r47","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1089\/thy.2018.0257","article-title":"Association between primary hypothyroidism and nonalcoholic fatty liver disease.","volume":"28","author":"Mantovani","year":"2018","journal-title":"Thyroid"},{"issue":"1","key":"jrv190006r48","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.atherosclerosis.2012.10.070","article-title":"Carotid intima-media thickness in patients with subclinical hypothyroidism: a meta-analysis.","volume":"227","author":"Gao","year":"2013","journal-title":"Atherosclerosis"},{"issue":"7","key":"jrv190006r49","doi-asserted-by":"publisher","first-page":"643","DOI":"10.5551\/jat.39917","article-title":"Effect of thyroxin treatment on carotid intima-media thickness (CIMT) reduction in patients with subclinical hypothyroidism (SCH): a meta-analysis of clinical trials.","volume":"24","author":"Aziz","year":"2017","journal-title":"J Atheroscler Thromb"},{"issue":"9","key":"jrv190006r50","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1161\/CIRCULATIONAHA.112.096024","article-title":"Subclinical thyroid dysfunction and the risk of heart failure events.","volume":"126","author":"Gencer","year":"2012","journal-title":"Circulation"},{"issue":"6","key":"jrv190006r51","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1210\/jc.2015-1438","article-title":"Subclinical hypothyroidism and the risk of stroke events and fatal stroke.","volume":"100","author":"Chaker","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"22","key":"jrv190006r52","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1161\/CIRCULATIONAHA.117.028753","article-title":"Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation.","volume":"136","author":"Baumgartner","year":"2017","journal-title":"Circulation"},{"issue":"9","key":"jrv190006r53","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1210\/jc.2014-1250","article-title":"Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease.","volume":"99","author":"Collet","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"jrv190006r54","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1210\/jc.2012-2180","article-title":"Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study.","volume":"98","author":"Hyland","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"jrv190006r55","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1210\/jc.2015-2046","article-title":"Subclinical hypothyroidism and cognitive impairment.","volume":"100","author":"Pasqualetti","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"jrv190006r56","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fnagi.2015.00150","article-title":"Subclinical hypothyroidism and cognitive function in people over 60 years.","volume":"7","author":"Akintola","year":"2015","journal-title":"Front Aging Neurosci"},{"issue":"12","key":"jrv190006r57","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.1210\/jc.2016-2129","article-title":"Subclinical thyroid dysfunction and the risk of cognitive decline.","volume":"101","author":"Rieben","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"jrv190006r58","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/ndt\/gfy071","article-title":"Low thyroid function is not associated with an accelerated deterioration in renal function.","volume":"34","author":"Meuwese","year":"2019","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"jrv190006r59","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1210\/jc.2014-4311","article-title":"Association of thyroid functional disease with mortality in a national cohort of incident hemodialysis patients.","volume":"100","author":"Rhee","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"jrv190006r60","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/joim.2018.283.issue-1","article-title":"Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts.","volume":"283","author":"Segna","year":"2018","journal-title":"J Intern Med"},{"issue":"2","key":"jrv190006r61","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1089\/thy.2013.0071","article-title":"Subclinical thyroid dysfunction and functional capacity among elderly.","volume":"24","author":"Virgini","year":"2014","journal-title":"Thyroid"},{"issue":"1","key":"jrv190006r62","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12958-018-0410-6","article-title":"Effect of levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism and thyroid autoimmuneity undergoing in vitro fertilization\/intracytoplasmic sperm injection.","volume":"16","author":"Rao","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"issue":"13","key":"jrv190006r63","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1001\/jama.2018.13770","article-title":"Association of thyroid hormone therapy with quality of life and thyroid-related symptoms in patients with subclinical hypothyroidism.","volume":"320","author":"Feller","year":"2018","journal-title":"JAMA"},{"issue":"8","key":"jrv190006r64","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1210\/jc.2018-00279","article-title":"Impact of thyroid hormone therapy on atherosclerosis in the elderly with subclinical hypothyroidism: a randomized trial.","volume":"103","author":"Blum","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"jrv190006r65","doi-asserted-by":"publisher","first-page":"35","DOI":"10.7326\/M14-1456","article-title":"Screening and treatment of thyroid dysfunction.","volume":"162","author":"Rugge","year":"2015","journal-title":"Ann Intern Med"},{"issue":"10","key":"jrv190006r66","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1001\/archinternmed.2012.1159","article-title":"Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality.","volume":"172","author":"Razvi","year":"2012","journal-title":"Arch Intern Med"},{"issue":"6","key":"jrv190006r67","doi-asserted-by":"publisher","first-page":"e0129793","DOI":"10.1371\/journal.pone.0129793","article-title":"Levothyroxine substitution in patients with subclinical hypothyroidism and the risk of myocardial infarction and mortality.","volume":"10","author":"Andersen","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"jrv190006r68","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1089\/thy.2012.0205","article-title":"Clinical practice guidelines for hypothyroidism in adults.","volume":"22","author":"Garber","year":"2012","journal-title":"Thyroid"},{"issue":"12","key":"jrv190006r69","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1089\/thy.2014.0028","article-title":"Guidelines for the treatment of hypothyroidism.","volume":"24","author":"Jonklaas","year":"2014","journal-title":"Thyroid"},{"issue":"4","key":"jrv190006r70","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000356507","article-title":"2013 ETA Guideline: management of subclinical hypothyroidism.","volume":"2","author":"Pearce","year":"2013","journal-title":"Eur Thyroid J"},{"issue":"4","key":"jrv190006r71","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1590\/S0004-27302013000400003","article-title":"Clinical practice guidelines for the management of hypothyroidism.","volume":"57","author":"Brenta","year":"2013","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"4","key":"jrv190006r72","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1210\/jc.2008-1696","article-title":"High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over.","volume":"94","author":"Somwaru","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"jrv190006r73","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1001\/jamainternmed.2013.11312","article-title":"Falling threshold for treatment of borderline elevated thyrotropin levels-balancing benefits and risks.","volume":"174","author":"Taylor","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"1","key":"jrv190006r74","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1210\/jc.2009-1625","article-title":"Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy.","volume":"95","author":"Flynn","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"jrv190006r75","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/cen.12824","article-title":"Management of primary hypothyroidism.","volume":"84","author":"Okosieme","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"jrv190006r76","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1210\/jc.2006-0099","article-title":"Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life.","volume":"91","author":"Walsh","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"jrv190006r77","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1210\/jc.2017-02668","article-title":"Effects of altering levothyroxine (L-T4) doses on quality of life, mood, and cognition in L-T4 treated subjects.","volume":"103","author":"Samuels","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"jrv190006r78","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1210\/jc.2018-01203","article-title":"Effects of altering levothyroxine dose on energy expenditure and body composition in subjects treated with LT4.","volume":"103","author":"Samuels","year":"2018","journal-title":"J Clin Endocrinol Metab"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jama\/article-pdf\/322\/2\/153\/17691495\/jama_biondi_2019_rv_190006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T15:49:23Z","timestamp":1610293763000},"score":1,"resource":{"primary":{"URL":"http:\/\/jama.jamanetwork.com\/article.aspx?doi=10.1001\/jama.2019.9052"}},"subtitle":["A Review"],"short-title":[],"issued":{"date-parts":[[2019,7,9]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,7,9]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2019.9052","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,9]]}}}