{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:07:59Z","timestamp":1792663679205,"version":"4.5.0"},"reference-count":18,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2020,8,4]]},"DOI":"10.1001\/jama.2020.10044","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T13:00:16Z","timestamp":1591189216000},"page":"460","source":"Crossref","is-referenced-by-count":923,"title":["Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19"],"prefix":"10.1001","volume":"324","author":[{"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guanggu District Maternal and Child Health Hospital of Hubei Province, Wuhan, China."},{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, the Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunliang","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Respiratory quality control center, National Center of Gerontology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Transfusion, General Hospital of Central Theater Command of PLA, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Kong","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Ren","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China"},{"name":"Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Hu","sequence":"additional","affiliation":[{"name":"Wuhan Red Cross Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihua","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Wuhan Asia Heart Hospital, Wuhan, China"},{"name":"Department of Blood Transfusion, Wuhan Asia General Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongpei","family":"Yu","sequence":"additional","affiliation":[{"name":"Peking University Clinical Research Institute, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Xu","sequence":"additional","affiliation":[{"name":"Wuhan Red Cross Hospital, Wuhan, China"},{"name":"Mianyang Central Hospital, Mianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guanggu District Maternal and Child Health Hospital of Hubei Province, Wuhan, China."},{"name":"Department of Organ Transplantation, First Affiliated Hospital, the Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan Red Cross Hospital, Wuhan, China"},{"name":"Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Pulmonary Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Wuhan Asia General Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyue","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China"},{"name":"Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"11","key":"joi200065r1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China.","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"issue":"13","key":"joi200065r2","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72?314 cases from the Chinese Center for Disease Control and Prevention.","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"joi200065r3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.tracli.2015.12.003","article-title":"Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.","volume":"23","author":"Garraud","year":"2016","journal-title":"Transfus Clin Biol"},{"issue":"1","key":"joi200065r4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s10096-004-1271-9","article-title":"Use of convalescent plasma therapy in SARS patients in Hong Kong.","volume":"24","author":"Cheng","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"5","key":"joi200065r5","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1093\/jac\/dki346","article-title":"Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital.","volume":"56","author":"Yeh","year":"2005","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"joi200065r6","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.3201\/eid2209.151164","article-title":"Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia.","volume":"22","author":"Arabi","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"joi200065r7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/cid\/civ334","article-title":"The use of TKM-100802 and convalescent plasma in 2 patients with Ebola virus disease in the United States.","volume":"61","author":"Kraft","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"16","key":"joi200065r8","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1001\/jama.2020.4783","article-title":"Treatment of 5 critically ill patients with COVID-19 with convalescent plasma.","volume":"323","author":"Shen","year":"2020","journal-title":"JAMA"},{"issue":"17","key":"joi200065r9","doi-asserted-by":"publisher","first-page":"9490","DOI":"10.1073\/pnas.2004168117","article-title":"Effectiveness of convalescent plasma therapy in severe COVID-19 patients.","volume":"117","author":"Duan","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10236","key":"joi200065r13","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/S0140-6736(20)31022-9","article-title":"Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"issue":"11","key":"joi200065r17","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/S2213-2600(19)30199-7","article-title":"Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial.","volume":"7","author":"Beigel","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"7","key":"joi200065r18","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1469-0691.2004.00956.x","article-title":"Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients.","volume":"10","author":"Soo","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"joi200065r14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-4757-2555-1","volume-title":"Survival Analysis. Statistics in the Health Sciences","author":"Kleinbaum","year":"1996"},{"key":"joi200065r10","unstructured":"Recommendations for Investigational COVID-19 Convalescent Plasma. US FDA. Published May 1, 2020. Accessed May 26, 2020. https:\/\/www.fda.gov\/vaccines-blood-biologics\/investigational-new-drug-ind-or-device-exemption-ide-process-cber\/recommendations-investigational-covid-19-convalescent-plasma"},{"key":"joi200065r11","unstructured":"Position Paper on Use of Convalescent Plasma, Serum or Immune Globulin Concentrates as an Element in Response to an Emerging Virus. In: Network WBR, ed. 2017. Accessed April 18, 2020. https:\/\/www.who.int\/bloodproducts\/brn\/en\/"},{"key":"joi200065r12","unstructured":"National Health Commission of the People\u2019s Republic of China. Covid-19 treatment plan (trial version 6). Accessed April 20, 2020. http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202002\/8334a8326dd94d329df351d7da8aefc2\/files\/b218cfeb1bc54639af227f922bf6b817"},{"key":"joi200065r15","unstructured":"Daily update on covid-19. National Health Commission of the People\u2019s Republic of China. Accessed May 24, 2020. http:\/\/www.nhc.gov.cn\/xcs\/yqtb\/202003\/f01fc26a8a7b48debe194bd1277fdba3.shtml"},{"key":"joi200065r16","unstructured":"Annual SHOT (Serious Hazards of Transfusion) Report 2018. Published July 2019. Accessed May 25, 2020. https:\/\/www.shotuk.org\/"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2766943\/jama_li_2020_oi_200065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:44:12Z","timestamp":1666770252000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2766943"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,8,4]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2020.10044","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738066145.793578637","asserted-by":"object"}]},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8,4]]}}}