{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:30:40Z","timestamp":1793392240429,"version":"4.5.0"},"reference-count":37,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2020,8,11]]},"DOI":"10.1001\/jama.2020.10888","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T11:02:04Z","timestamp":1595847724000},"page":"581","source":"Crossref","is-referenced-by-count":153,"title":["Association of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis"],"prefix":"10.1001","volume":"324","author":[{"given":"Peter C.","family":"Minneci","sequence":"first","affiliation":[{"name":"Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Department of Pediatric Surgery, Nationwide Children\u2019s Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn M.","family":"Hade","sequence":"additional","affiliation":[{"name":"Departments of Biomedical Informatics and Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Department of Pediatric Surgery, Nationwide Children\u2019s Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri V.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Z.","family":"Mak","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery, University of Chicago Medicine and Biologic Sciences, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Fox","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery, University of Chicago Medicine and Biologic Sciences, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Hirschl","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Michigan School of Medicine, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Gadepalli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Michigan School of Medicine, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Helmrath","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Kohler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Leys","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave R.","family":"Lal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Landman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kabre","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Fallat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Deans","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Department of Pediatric Surgery, Nationwide Children\u2019s Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Midwest Pediatric Surgery Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"320","key":"joi200070r1","first-page":"1","article-title":"National hospital ambulatory medical care survey: 1999 emergency department summary.","author":"McCaig","year":"2001","journal-title":"Adv Data"},{"issue":"8","key":"joi200070r3","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jpedsurg.2007.03.049","article-title":"Nonoperative treatment of acute appendicitis in children.","volume":"42","author":"Abes","year":"2007","journal-title":"J Pediatr Surg"},{"issue":"1","key":"joi200070r4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jamcollsurg.2012.02.024","article-title":"A prospective treatment protocol for outpatient laparoscopic appendectomy for acute appendicitis.","volume":"215","author":"Cash","year":"2012","journal-title":"J Am Coll Surg"},{"issue":"3","key":"joi200070r5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5505\/tjtes.2013.58234","article-title":"Comparison of open and laparoscopic appendectomy in uncomplicated appendicitis: a prospective randomized clinical trial.","volume":"19","author":"Kocatas","year":"2013","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"5","key":"joi200070r6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jamasurg.2015.4534","article-title":"Effectiveness of patient choice in nonoperative vs surgical management of pediatric uncomplicated acute appendicitis.","volume":"151","author":"Minneci","year":"2016","journal-title":"JAMA Surg"},{"issue":"23","key":"joi200070r7","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1001\/jama.2015.6154","article-title":"Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial.","volume":"313","author":"Salminen","year":"2015","journal-title":"JAMA"},{"issue":"5","key":"joi200070r8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1503\/cjs.006610","article-title":"Antibiotics versus appendectomy in the management of acute appendicitis: a review of the current evidence.","volume":"54","author":"Fitzmaurice","year":"2011","journal-title":"Can J Surg"},{"issue":"1","key":"joi200070r9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/SLA.0000000000000835","article-title":"Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial.","volume":"261","author":"Svensson","year":"2015","journal-title":"Ann Surg"},{"issue":"11","key":"joi200070r10","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.jpedsurg.2015.07.008","article-title":"Long-term outcomes of operative versus nonoperative treatment for uncomplicated appendicitis.","volume":"50","author":"Tanaka","year":"2015","journal-title":"J Pediatr Surg"},{"key":"joi200070r11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cct.2019.06.013","article-title":"Multi-institutional trial of non-operative management and surgery for uncomplicated appendicitis in children: design and rationale.","volume":"83","author":"Minneci","year":"2019","journal-title":"Contemp Clin Trials"},{"issue":"3","key":"joi200070r12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00005650-200503000-00008","article-title":"The PedsQL: reliability and validity of the short-form generic core scales and asthma module.","volume":"43","author":"Chan","year":"2005","journal-title":"Med Care"},{"issue":"2","key":"joi200070r13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00005650-199902000-00003","article-title":"The PedsQL: measurement model for the pediatric quality of life inventory.","volume":"37","author":"Varni","year":"1999","journal-title":"Med Care"},{"issue":"6","key":"joi200070r14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2","article-title":"The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity.","volume":"3","author":"Varni","year":"2003","journal-title":"Ambul Pediatr"},{"issue":"4","key":"joi200070r15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.pcl.2009.05.016","article-title":"The pediatric quality of life inventory: measuring pediatric health-related quality of life from the perspective of children and their parents.","volume":"56","author":"Varni","year":"2009","journal-title":"Pediatr Clin North Am"},{"issue":"2","key":"joi200070r16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1014836921812","article-title":"The PedsQL 4.0 Generic Core Scales: sensitivity, responsiveness, and impact on clinical decision-making.","volume":"25","author":"Varni","year":"2002","journal-title":"J Behav Med"},{"key":"joi200070r17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1477-7525-2-55","article-title":"The PedsQL family impact module: preliminary reliability and validity.","volume":"2","author":"Varni","year":"2004","journal-title":"Health Qual Life Outcomes"},{"issue":"1","key":"joi200070r18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0272989X9601600114","article-title":"Patient satisfaction with health care decisions: the satisfaction with decision scale.","volume":"16","author":"Holmes-Rovner","year":"1996","journal-title":"Med Decis Making"},{"issue":"2","key":"joi200070r19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1369-6513.2003.00220.x","article-title":"Preliminary validation of the satisfaction with decision scale with depressed primary care patients.","volume":"6","author":"Wills","year":"2003","journal-title":"Health Expect"},{"issue":"3","key":"joi200070r20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2307\/2336502","article-title":"Discrete sequential boundaries for clinical-trials.","volume":"70","author":"Lan","year":"1983","journal-title":"Biometrika."},{"issue":"19","key":"joi200070r21","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/sim.1903","article-title":"Stratification and weighting via the propensity score in estimation of causal treatment effects: a comparative study.","volume":"23","author":"Lunceford","year":"2004","journal-title":"Stat Med"},{"issue":"5","key":"joi200070r22","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/00001648-200009000-00011","article-title":"Marginal structural models and causal inference in epidemiology.","volume":"11","author":"Robins","year":"2000","journal-title":"Epidemiology"},{"issue":"1","key":"joi200070r23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects.","volume":"70","author":"Rosenbaum","year":"1983","journal-title":"Biometrika"},{"issue":"6","key":"joi200070r24","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/aje\/kwn164","article-title":"Constructing inverse probability weights for marginal structural models.","volume":"168","author":"Cole","year":"2008","journal-title":"Am J Epidemiol"},{"issue":"1","key":"joi200070r25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/0962280212445945","article-title":"A comparison of two methods of estimating propensity scores after multiple imputation.","volume":"25","author":"Mitra","year":"2016","journal-title":"Stat Methods Med Res"},{"issue":"6","key":"joi200070r26","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1177\/0962280216674296","article-title":"Comments on propensity score matching following multiple imputation.","volume":"25","author":"Penning de Vries","year":"2016","journal-title":"Stat Methods Med Res"},{"issue":"3","key":"joi200070r27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/0962280206075304","article-title":"Multiple imputation: current perspectives.","volume":"16","author":"Kenward","year":"2007","journal-title":"Stat Methods Med Res"},{"issue":"1","key":"joi200070r28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2307\/2533148","article-title":"Pattern-mixture models for multivariate incomplete data with covariates.","volume":"52","author":"Little","year":"1996","journal-title":"Biometrics"},{"issue":"5","key":"joi200070r29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00001648-200009000-00012","article-title":"Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.","volume":"11","author":"Hern\u00e1n","year":"2000","journal-title":"Epidemiology"},{"issue":"28","key":"joi200070r30","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/sim.6607","article-title":"Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies.","volume":"34","author":"Austin","year":"2015","journal-title":"Stat Med"},{"issue":"5","key":"joi200070r31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00431-019-03555-w","article-title":"Parental preferences in treatment of acute uncomplicated appendicitis comparing surgery to conservative management with antibiotics and their views on research participation.","volume":"179","author":"Kyaw","year":"2020","journal-title":"Eur J Pediatr"},{"issue":"6","key":"joi200070r32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.5009","article-title":"Effects of a patient activation tool on decision making between surgery and nonoperative management for pediatric appendicitis: a randomized clinical trial.","volume":"2","author":"Minneci","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"1","key":"joi200070r33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.annemergmed.2016.08.446","article-title":"antibiotics-first versus surgery for appendicitis: a us pilot randomized controlled trial allowing outpatient antibiotic management.","volume":"70","author":"Talan","year":"2017","journal-title":"Ann Emerg Med"},{"issue":"11","key":"joi200070r34","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016117","article-title":"Comparison of Outcomes of antibiotic Drugs and Appendectomy (CODA) trial: a protocol for the pragmatic randomised study of appendicitis treatment.","volume":"7","author":"Davidson","year":"2017","journal-title":"BMJ Open"},{"issue":"1","key":"joi200070r35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jpedsurg.2017.10.014","article-title":"Expanding the inclusion criteria for nonoperative management of uncomplicated appendicitis: outcomes and cost.","volume":"53","author":"Lee","year":"2017","journal-title":"J Pediatr Surg"},{"issue":"3","key":"joi200070r36","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3003","article-title":"Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis.","volume":"139","author":"Georgiou","year":"2017","journal-title":"Pediatrics"},{"issue":"12","key":"joi200070r37","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1001\/jama.2018.13201","article-title":"Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial.","volume":"320","author":"Salminen","year":"2018","journal-title":"JAMA"},{"key":"joi200070r2","volume-title":"Ambulatory and Inpatient Procedures in the United States, 1996","author":"Owings","year":"1998"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2768929\/jama_minneci_2020_oi_200070_1596830761.19266.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T18:57:03Z","timestamp":1597172223000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2768929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8,11]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2020.10888","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8,11]]}}}