{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:45:46Z","timestamp":1792197946364,"version":"4.4.0"},"reference-count":70,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2020,3,24]]},"DOI":"10.1001\/jama.2020.2298","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T12:17:30Z","timestamp":1585052250000},"page":"1175","source":"Crossref","is-referenced-by-count":1327,"title":["Nonalcoholic Steatohepatitis"],"prefix":"10.1001","volume":"323","author":[{"given":"Adam C.","family":"Sheka","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyedele","family":"Adeyi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Hameed","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeed","family":"Ikramuddin","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"jrv200001r1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"jrv200001r2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases.","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"jrv200001r3","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology"},{"issue":"11","key":"jrv200001r4","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1038\/s41395-018-0088-6","article-title":"NASH leading cause of liver transplant in women: updated analysis of indications for liver transplant and ethnic and gender variances.","volume":"113","author":"Noureddin","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"jrv200001r5","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/apt.14937","article-title":"Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases.","volume":"48","author":"Stine","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"jrv200001r6","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/hep.v69.2","article-title":"Burden of illness and economic model for patients with nonalcoholic steatohepatitis in the United States.","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"issue":"1","key":"jrv200001r7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.v64.1","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta-analytic assessment of prevalence, incidence, and outcomes.","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"jrv200001r8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease.","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"issue":"5","key":"jrv200001r9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.4254\/wjh.v6.i5.274","article-title":"Gender and racial differences in nonalcoholic fatty liver disease.","volume":"6","author":"Pan","year":"2014","journal-title":"World J Hepatol"},{"issue":"1","key":"jrv200001r10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","article-title":"Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.","volume":"140","author":"Williams","year":"2011","journal-title":"Gastroenterology"},{"issue":"2","key":"jrv200001r11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/jgh.2006.21.issue-2","article-title":"Living donor liver transplantation: histological abnormalities found on liver biopsies of apparently healthy potential donors.","volume":"21","author":"Tran","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"jrv200001r12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jhep.2008.10.030","article-title":"Liver biopsy findings from healthy potential living liver donors: reasons for disqualification, silent diseases and correlation with liver injury tests.","volume":"50","author":"Minervini","year":"2009","journal-title":"J Hepatol"},{"issue":"4","key":"jrv200001r13","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.","volume":"69","author":"Estes","year":"2018","journal-title":"J Hepatol"},{"issue":"198","key":"jrv200001r14","first-page":"198","article-title":"Trends in elevated triglyceride in adults: United States, 2001-2012.","volume":"198","author":"Carroll","year":"2015","journal-title":"NCHS Data Brief"},{"issue":"288","key":"jrv200001r15","first-page":"1","article-title":"Prevalence of obesity among adults and youth: United States, 2015-2016.","volume":"288","author":"Hales","year":"2017","journal-title":"NCHS Data Brief"},{"key":"jrv200001r16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.ijcard.2018.01.139","article-title":"Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014.","volume":"259","author":"Shin","year":"2018","journal-title":"Int J Cardiol"},{"issue":"289","key":"jrv200001r17","first-page":"1","article-title":"Hypertension prevalence and control among adults: United States, 2015-2016.","volume":"289","author":"Fryar","year":"2017","journal-title":"NCHS Data Brief"},{"issue":"319","key":"jrv200001r18","first-page":"1","article-title":"Prevalence of total, diagnosed, and undiagnosed diabetes among adults: United States, 2013-2016.","volume":"319","author":"Mendola","year":"2018","journal-title":"NCHS Data Brief"},{"issue":"3","key":"jrv200001r19","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1381\/0960892053576820","article-title":"Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients.","volume":"15","author":"Ong","year":"2005","journal-title":"Obes Surg"},{"issue":"2","key":"jrv200001r20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1055\/s-00000069","article-title":"Fibrosis in nonalcoholic Fatty liver disease: mechanisms and clinical implications.","volume":"35","author":"Angulo","year":"2015","journal-title":"Semin Liver Dis"},{"issue":"2","key":"jrv200001r21","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic feature, associated with outcomes of patients with nonalcoholic fatty liver disease.","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"issue":"5","key":"jrv200001r22","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/hep.27368","article-title":"Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up.","volume":"61","author":"Ekstedt","year":"2015","journal-title":"Hepatology"},{"issue":"6","key":"jrv200001r23","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/(ISSN)1527-3350","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease.","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"2","key":"jrv200001r24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/hep.23521","article-title":"Long-term mortality in NAFLD: is liver histology of any prognostic significance?","volume":"51","author":"Angulo","year":"2010","journal-title":"Hepatology"},{"issue":"4","key":"jrv200001r25","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.jhep.2008.06.018","article-title":"Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease.","volume":"49","author":"Ong","year":"2008","journal-title":"J Hepatol"},{"issue":"4","key":"jrv200001r26","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/(ISSN)1527-3350","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes.","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"issue":"7","key":"jrv200001r27","first-page":"434","article-title":"Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.","volume":"55","author":"Ludwig","year":"1980","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"jrv200001r28","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/hep.v54.1","article-title":"Endpoints and clinical trial design for nonalcoholic steatohepatitis.","volume":"54","author":"Sanyal","year":"2011","journal-title":"Hepatology"},{"issue":"10","key":"jrv200001r29","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1111\/apt.15503","article-title":"Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials.","volume":"50","author":"Pai","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"issue":"27","key":"jrv200001r30","first-page":"9026","article-title":"Role of liver biopsy in nonalcoholic fatty liver disease.","volume":"20","author":"Nalbantoglu","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"18","key":"jrv200001r31","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.","volume":"362","author":"Sanyal","year":"2010","journal-title":"N Engl J Med"},{"issue":"3","key":"jrv200001r32","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1002\/hep.24127","article-title":"The NAS and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings.","volume":"53","author":"Brunt","year":"2011","journal-title":"Hepatology"},{"issue":"2","key":"jrv200001r33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/(ISSN)1527-3350","article-title":"An algorithm for the grading of activity in chronic hepatitis C.","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"issue":"10","key":"jrv200001r34","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.12565","article-title":"Association of histologic disease activity with progression of nonalcoholic fatty liver disease.","volume":"2","author":"Kleiner","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"5","key":"jrv200001r35","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jhep.2012.11.021","article-title":"Non-invasive diagnosis of non-alcoholic fatty liver disease: a critical appraisal.","volume":"58","author":"Machado","year":"2013","journal-title":"J Hepatol"},{"issue":"3","key":"jrv200001r36","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/hep.24452","article-title":"Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis.","volume":"54","author":"Hernaez","year":"2011","journal-title":"Hepatology"},{"issue":"3","key":"jrv200001r37","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/0284185115580488","article-title":"A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease.","volume":"57","author":"Idilman","year":"2016","journal-title":"Acta Radiol"},{"issue":"6","key":"jrv200001r38","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1002\/hep.v60.6","article-title":"Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study.","volume":"60","author":"Loomba","year":"2014","journal-title":"Hepatology"},{"issue":"9","key":"jrv200001r39","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1111\/liv.2013.33.issue-9","article-title":"Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD).","volume":"33","author":"Verma","year":"2013","journal-title":"Liver Int"},{"issue":"4","key":"jrv200001r40","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/ajg.1999.94.issue-4","article-title":"The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease.","volume":"94","author":"Sorbi","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"jrv200001r41","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/hep.v48:3","article-title":"Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes.","volume":"48","author":"Fracanzani","year":"2008","journal-title":"Hepatology"},{"issue":"1","key":"jrv200001r42","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/hep.27395","article-title":"The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease.","volume":"61","author":"Maximos","year":"2015","journal-title":"Hepatology"},{"issue":"6","key":"jrv200001r43","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1053\/jhep.2003.50229","article-title":"Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values.","volume":"37","author":"Mofrad","year":"2003","journal-title":"Hepatology"},{"issue":"4","key":"jrv200001r44","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/(ISSN)1527-3350","article-title":"The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD.","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology"},{"issue":"8","key":"jrv200001r45","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3109\/07853890.2010.518623","article-title":"Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity.","volume":"43","author":"Musso","year":"2011","journal-title":"Ann Med"},{"issue":"1","key":"jrv200001r46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/(ISSN)1527-3350","article-title":"FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.","volume":"46","author":"Vallet-Pichard","year":"2007","journal-title":"Hepatology"},{"issue":"10","key":"jrv200001r47","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cgh.2009.05.033","article-title":"Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.","volume":"7","author":"Shah","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"jrv200001r48","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/hep.23535","article-title":"Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.","volume":"51","author":"Abdelmalek","year":"2010","journal-title":"Hepatology"},{"issue":"9","key":"jrv200001r49","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.cgh.2018.01.026","article-title":"Among patients with nonalcoholic fatty liver disease, modest alcohol use is associated with less improvement in histologic steatosis and steatohepatitis.","volume":"16","author":"Ajmera","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"jrv200001r50","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3727\/105221617X15124844266408","article-title":"The effects of physical exercise on fatty liver disease.","volume":"18","author":"van der Windt","year":"2018","journal-title":"Gene Expr"},{"issue":"3","key":"jrv200001r51","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cgh.2014.08.039","article-title":"Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis.","volume":"13","author":"Patel","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"jrv200001r52","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00125-011-2446-4","article-title":"Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials.","volume":"55","author":"Musso","year":"2012","journal-title":"Diabetologia"},{"issue":"2","key":"jrv200001r53","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis.","volume":"149","author":"Vilar-Gomez","year":"2015","journal-title":"Gastroenterology"},{"issue":"22","key":"jrv200001r54","first-page":"2416","article-title":"Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity.","volume":"310","author":"Courcoulas","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"jrv200001r55","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1001\/jama.2017.20813","article-title":"Lifestyle intervention and medical management with vs without Roux-en-Y gastric bypass and control of hemoglobin A1c, LDL cholesterol, and systolic blood pressure at 5 years in the Diabetes Surgery Study.","volume":"319","author":"Ikramuddin","year":"2018","journal-title":"JAMA"},{"issue":"13","key":"jrv200001r56","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1001\/jama.2019.14231","article-title":"Association of metabolic surgery with major adverse cardiovascular outcomes in patients with type 2 diabetes and obesity.","volume":"322","author":"Aminian","year":"2019","journal-title":"JAMA"},{"issue":"12","key":"jrv200001r57","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1007\/s11695-015-1691-x","article-title":"Bariatric surgery and non-alcoholic fatty liver disease: a systematic review of liver biochemistry and histology.","volume":"25","author":"Bower","year":"2015","journal-title":"Obes Surg"},{"issue":"2","key":"jrv200001r58","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1053\/j.gastro.2009.04.052","article-title":"Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease.","volume":"137","author":"Mathurin","year":"2009","journal-title":"Gastroenterology"},{"issue":"2","key":"jrv200001r59","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1053\/j.gastro.2015.04.014","article-title":"Bariatric surgery reduces features of nonalcoholic steatohepatitis in morbidly obese patients.","volume":"149","author":"Lassailly","year":"2015","journal-title":"Gastroenterology"},{"issue":"2","key":"jrv200001r60","doi-asserted-by":"publisher","first-page":"487S","DOI":"10.1093\/ajcn\/55.2.487s","article-title":"Gastrointestinal surgery for severe obesity. Proceedings of a National Institutes of Health Consensus Development Conference. March 25-27, 1991, Bethesda, MD.","volume":"55","year":"1992","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"jrv200001r61","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1007\/s11695-015-1727-2","article-title":"A systematic review of bariatric surgery in patients with liver cirrhosis.","volume":"25","author":"Jan","year":"2015","journal-title":"Obes Surg"},{"issue":"14","key":"jrv200001r62","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.3748\/wjg.v24.i14.1491","article-title":"Nonalcoholic fatty liver disease and liver transplantation\u2014where do we stand?","volume":"24","author":"Mikolasevic","year":"2018","journal-title":"World J Gastroenterol"},{"issue":"2","key":"jrv200001r63","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2174\/1874609811104020158","article-title":"Vitamin E and all-cause mortality: a meta-analysis.","volume":"4","author":"Abner","year":"2011","journal-title":"Curr Aging Sci"},{"issue":"1","key":"jrv200001r64","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/MOU.0000000000000460","article-title":"Nutrition, physical activity, and lifestyle factors in prostate cancer prevention.","volume":"28","author":"Ballon-Landa","year":"2018","journal-title":"Curr Opin Urol"},{"key":"jrv200001r65","doi-asserted-by":"publisher","first-page":"c5702","DOI":"10.1136\/bmj.c5702","article-title":"Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials.","volume":"341","author":"Sch\u00fcrks","year":"2010","journal-title":"BMJ"},{"issue":"14","key":"jrv200001r66","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1001\/jama.2011.1437","article-title":"Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).","volume":"306","author":"Klein","year":"2011","journal-title":"JAMA"},{"issue":"10019","key":"jrv200001r67","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0140-6736(15)00803-X","article-title":"Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.","volume":"387","author":"Armstrong","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"jrv200001r68","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.dld.2014.07.170","article-title":"The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease.","volume":"47","author":"Pastori","year":"2015","journal-title":"Dig Liver Dis"},{"issue":"10","key":"jrv200001r69","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1016\/j.jacc.2019.03.010","article-title":"2019 ACC\/AHA Guideline on the primary prevention of cardiovascular\u00a0disease: a report of the American College of Cardiology\/American Heart Association Task\u00a0Force\u00a0on\u00a0Clinical Practice Guidelines.","volume":"74","author":"Arnett","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"jrv200001r70","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.jhep.2015.05.006","article-title":"Statin use and non-alcoholic steatohepatitis in at risk individuals.","volume":"63","author":"Dongiovanni","year":"2015","journal-title":"J Hepatol"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2763297\/jama_sheka_2020_rv_200001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T11:01:27Z","timestamp":1588071687000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2763297"}},"subtitle":["A Review"],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,3,24]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2020.2298","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,24]]}}}