{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:26:03Z","timestamp":1793330763053,"version":"4.5.0"},"reference-count":37,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2021,1,12]]},"DOI":"10.1001\/jama.2020.24991","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T02:00:29Z","timestamp":1610589629000},"page":"146","source":"Crossref","is-referenced-by-count":544,"title":["Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses in the US, 2010-2017"],"prefix":"10.1001","volume":"325","author":[{"given":"Ashley H.","family":"Hirai","sequence":"first","affiliation":[{"name":"Maternal and Child Health Bureau, Health Resources and Services Administration Department of Health and Human Services, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Y.","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention Department of Health and Human Services, Atlanta, Georgia"},{"name":"Commissioned Corps Public Health Service Department of Health and Human Services, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L.","family":"Owens","sequence":"additional","affiliation":[{"name":"Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality Department of Health and Human Services, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Stocks","sequence":"additional","affiliation":[{"name":"West Virginia University, School of Public Health, Morgantown"},{"name":"formerly with the Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality Department of Health and Human Services, Rockville, Maryland at the time of analysis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Patrick","sequence":"additional","affiliation":[{"name":"Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention Department of Health and Human Services, Atlanta, Georgia"},{"name":"Department of Pediatrics, Vanderbilt Center for Child Health Policy, Nashville, Tennessee"},{"name":"Department of Health Policy, Vanderbilt Center for Child Health Policy, Nashville, Tennessee"},{"name":"Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"31","key":"joi200137r1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.15585\/mmwr.mm6731a1","article-title":"Opioid use disorder documented at delivery hospitalization: United States, 1999-2014.","volume":"67","author":"Haight","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"18","key":"joi200137r2","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1001\/jama.2012.3951","article-title":"Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.","volume":"307","author":"Patrick","year":"2012","journal-title":"JAMA"},{"issue":"4","key":"joi200137r3","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-3520","article-title":"Incidence and costs of neonatal abstinence syndrome among infants with Medicaid: 2004-2014.","volume":"141","author":"Winkelman","year":"2018","journal-title":"Pediatrics"},{"issue":"25","key":"joi200137r4","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1056\/NEJMra1600879","article-title":"Neonatal abstinence syndrome.","volume":"375","author":"McQueen","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"joi200137r5","doi-asserted-by":"publisher","first-page":"e547","DOI":"10.1542\/peds.2013-3524","article-title":"Neonatal abstinence syndrome.","volume":"134","author":"Kocherlakota","year":"2014","journal-title":"Pediatrics"},{"issue":"1","key":"joi200137r6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.2105\/AJPH.2018.304771","article-title":"Amphetamine- and opioid-affected births: incidence, outcomes, and costs, United States, 2004-2015.","volume":"109","author":"Admon","year":"2019","journal-title":"Am J Public Health"},{"issue":"6","key":"joi200137r7","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1097\/ALN.0000000000000472","article-title":"Opioid abuse and dependence during pregnancy: temporal trends and obstetrical outcomes.","volume":"121","author":"Maeda","year":"2014","journal-title":"Anesthesiology"},{"issue":"31","key":"joi200137r8","doi-asserted-by":"publisher","first-page":"799","DOI":"10.15585\/mmwr.mm6531a2","article-title":"Incidence of neonatal abstinence syndrome: 28 States, 1999-2013.","volume":"65","author":"Ko","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"11","key":"joi200137r9","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1097\/MLR.0000000000000805","article-title":"Trends in opioid-related inpatient stays shifted after the us transitioned to ICD-10-CM diagnosis coding in 2015.","volume":"55","author":"Heslin","year":"2017","journal-title":"Med Care"},{"issue":"2","key":"joi200137r13","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1001\/jamapediatrics.2016.3750","article-title":"Rural and urban differences in neonatal abstinence syndrome and maternal opioid use, 2004 to 2013.","volume":"171","author":"Villapiano","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"4","key":"joi200137r16","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s10995-007-0256-6","article-title":"An enhanced method for identifying obstetric deliveries.","volume":"12","author":"Kuklina","year":"2008","journal-title":"Matern Child Health J"},{"issue":"1","key":"joi200137r19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/1475-6773.12612","article-title":"Adjusting health expenditures for inflation: a review of measures for health services research in the United States.","volume":"53","author":"Dunn","year":"2018","journal-title":"Health Serv Res"},{"issue":"36","key":"joi200137r26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.15585\/mmwr.mm6836a1","article-title":"State strategies to address opioid use disorder among pregnant and postpartum women and infants prenatally exposed to substances, including infants with neonatal abstinence syndrome.","volume":"68","author":"Kroelinger","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"joi200137r27","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-4183","article-title":"Positive predictive value of administrative data for neonatal abstinence syndrome.","volume":"143","author":"Maalouf","year":"2019","journal-title":"Pediatrics"},{"issue":"29","key":"joi200137r28","doi-asserted-by":"publisher","first-page":"951","DOI":"10.15585\/mmwr.mm6929a2","article-title":"Identification of substance-exposed newborns and neonatal abstinence syndrome using ICD-10-CM: 15 hospitals, Massachusetts, 2017.","volume":"69","author":"Goyal","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"joi200137r29","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-0567","article-title":"Diagnosis codes and case definitions for neonatal abstinence syndrome.","volume":"146","author":"Elmore","year":"2020","journal-title":"Pediatrics"},{"issue":"9","key":"joi200137r31","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.2105\/AJPH.2019.305170","article-title":"Standardization of state definitions for neonatal abstinence syndrome surveillance and the opioid crisis.","volume":"109","author":"Chiang","year":"2019","journal-title":"Am J Public Health"},{"issue":"3","key":"joi200137r32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.0338","article-title":"Association of criminal statutes for opioid use disorder with prevalence and treatment among pregnant women with commercial insurance in the United States.","volume":"2","author":"Gressler","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"4","key":"joi200137r36","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1001\/jama.2018.20851","article-title":"Association among county-level economic factors, clinician supply, metropolitan or rural location, and neonatal abstinence syndrome.","volume":"321","author":"Patrick","year":"2019","journal-title":"JAMA"},{"key":"joi200137r14","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013","edition":"5th ed"},{"key":"joi200137r22","volume-title":"Measuring Progress Toward Target Attainment and the Elimination of Health Disparities in Healthy People 2020","author":"Talih","year":"2016"},{"key":"joi200137r10","unstructured":"Healthcare Cost and Utilization Project. Overview of HCUP. Agency for Healthcare Research and Quality. Updated October 1, 2019. Accessed June 30, 2020. https:\/\/www.hcup-us.ahrq.gov\/overview.jsp"},{"key":"joi200137r11","unstructured":"Healthcare Cost and Utilization Project (HCUP). Overview of the National (Nationwide) Inpatient Sample (NIS). Agency for Healthcare Research and Quality. Accessed October 16, 2020. https:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp"},{"key":"joi200137r12","unstructured":"Healthcare Cost and Utilization Project. Overview of the State Inpatient Databases (SID). Agency for Healthcare Research and Quality. Accessed October 16, 2020. https:\/\/www.hcup-us.ahrq.gov\/sidoverview.jsp"},{"key":"joi200137r15","unstructured":"Condition categories. Chronic Conditions Data Warehouse. Accessed June 30, 2020. https:\/\/www2.ccwdata.org\/web\/guest\/condition-categories"},{"key":"joi200137r17","unstructured":"Healthcare Cost and Utilization Project. Cost-to-Charge Ratio Files. Agency for Healthcare Research and Quality. Accessed June 30, 2020. https:\/\/hcup-us.ahrq.gov\/db\/state\/costtocharge.jsp"},{"key":"joi200137r18","unstructured":"Bureau of Economic Analysis. Table 1.1.4: price indexes for gross domestic product. Accessed June 30, 2020. https:\/\/apps.bea.gov\/iTable\/iTable.cfm?reqid=19&step=2#reqid=19&step=2&isuri=1&1921=survey"},{"key":"joi200137r20","unstructured":"Barrett? M, Mummert? A, Kenney? T, Heslin? K. Methods Applying AHRQ Quality Indicators to Healthcare Cost and Utilization Project (HCUP) Data for the 2018 National Healthcare Quality and Disparities Report (QDR). US Agency for Healthcare Research and Quality; 2019. Accessed June 30, 2020. https:\/\/www.hcup-us.ahrq.gov\/reports\/methods\/2019-01.pdf"},{"key":"joi200137r21","unstructured":"Urban Influence Codes. US Dept of Agriculture. Updated October 24, 2019. Accessed June 30, 2020. https:\/\/www.ers.usda.gov\/data-products\/urban-influence-codes\/"},{"key":"joi200137r23","unstructured":"Healthcare Cost and Utilization Project. Neonatal Abstinence Syndrome Births: Trends in the United States, 2008-2019. Agency for Healthcare Research and Quality; 2020. Accessed June 17, 2020. https:\/\/hcup-us.ahrq.gov\/reports\/ataglance\/HCUPtrendsNASbirthsUS.pdf"},{"key":"joi200137r24","unstructured":"5-Point strategy to combat the opioid crisis. US Dept of Health and Human Services. Accessed March 11, 2020. https:\/\/www.hhs.gov\/opioids\/about-the-epidemic\/hhs-response\/index.html"},{"key":"joi200137r25","unstructured":"Preventing opioid misuse and overdose in the states and territories. Association of State and Territorial Health Officials. Accessed October 16, 2020. https:\/\/my.astho.org\/opioids\/home"},{"key":"joi200137r30","unstructured":"Table 6.66B: illicit drug use, marijuana use, and opioid use in past month among females aged 15 to 44, by pregnancy status, demographic, socioeconomic, and pregnancy characteristics: percentages, 2016 and 2017. Substance Abuse and Mental Health Services Administration. Accessed June 30, 2020. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/cbhsq-reports\/NSDUHDetailedTabs2017\/NSDUHDetailedTabs2017.htm#tab6-66B"},{"key":"joi200137r33","unstructured":"Substance use during pregnancy. Guttmacher Institute. Accessed June 30, 2020. https:\/\/www.guttmacher.org\/state-policy\/explore\/substance-use-during-pregnancy"},{"key":"joi200137r34","unstructured":"Neonatal Abstinence Syndrome Standardized Case Definition. Council of State and Territorial Epidemiologists; 2019. Accessed June 30, 2020. https:\/\/cdn.ymaws.com\/www.cste.org\/resource\/resmgr\/2019ps\/final\/19-MCH-01_final_7.31.19.pdf"},{"key":"joi200137r35","unstructured":"The drug overdose epidemic: behind the numbers. Centers for Disease Control and Prevention. Accessed October 14, 2020. https:\/\/www.cdc.gov\/drugoverdose\/data\/index.html"},{"key":"joi200137r37","unstructured":"? Fingar? KR, Stocks? C, Henke? RM, . The distribution and correlates of neonatal abstinence syndrome across counties in the United States, 2016. Accessed June 30, 2020.https:\/\/academyhealth.confex.com\/academyhealth\/2019arm\/meetingapp.cgi\/Paper\/33577"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2774834\/jama_hirai_2021_oi_200137_1623095860.21157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:14:31Z","timestamp":1623154471000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2774834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,1,12]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2020.24991","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,12]]}}}