{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:29:00Z","timestamp":1791390540525,"version":"4.3.3"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2021,2,9]]},"DOI":"10.1001\/jama.2020.27205","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T12:44:29Z","timestamp":1612961069000},"page":"561","source":"Crossref","is-referenced-by-count":149,"title":["Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark"],"prefix":"10.1001","volume":"325","author":[{"given":"Anne-Sophie","family":"Sillesen","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottilia","family":"V\u00f8gg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pihl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Axelsson","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundberg","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Center of Fetal Medicine and Pregnancy, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Vedel","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Center of Fetal Medicine and Pregnancy, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Zingenberg","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Center of Fetal Medicine, Department of Obstetrics and Gynecology, Copenhagen University Hospital Herlev, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"17","key":"joi200146r1","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/heartjnl-2016-309916","article-title":"Contemporary natural history of bicuspid aortic valve disease: a systematic review.","volume":"103","author":"Masri","year":"2017","journal-title":"Heart"},{"key":"joi200146r2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/145202","article-title":"Bicuspid aortic valve disease and ascending aortic aneurysms: gaps in knowledge.","volume":"2012","author":"Losenno","year":"2012","journal-title":"Cardiol Res Pract"},{"issue":"2","key":"joi200146r3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/ejcts\/ezv087","article-title":"New insights in the association between bicuspid aortic valve phenotype, aortic configuration and valve haemodynamics.","volume":"49","author":"Sievers","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"issue":"20","key":"joi200146r4","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1056\/NEJMra1207059","article-title":"Aortic dilatation in patients with bicuspid aortic valve.","volume":"370","author":"Verma","year":"2014","journal-title":"N Engl J Med"},{"issue":"5","key":"joi200146r5","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.jtcvs.2007.01.039","article-title":"A classification system for the bicuspid aortic valve from 304 surgical specimens.","volume":"133","author":"Sievers","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"joi200146r6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2459\/JCM.0000000000000430","article-title":"Clinical and echocardiographic predictors of long-term outcome of a large cohort of patients with bicuspid aortic valve.","volume":"18","author":"Morosin","year":"2017","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"1","key":"joi200146r7","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jtcvs.2014.05.014","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines.","volume":"148","author":"Nishimura","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"joi200146r8","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/HCO.0000000000000328","article-title":"Genetics of bicuspid aortic valve aortopathy.","volume":"31","author":"Andreassi","year":"2016","journal-title":"Curr Opin Cardiol"},{"issue":"8","key":"joi200146r9","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.jacc.2014.04.073","article-title":"A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium).","volume":"64","author":"Prakash","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"joi200146r10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12967-017-1176-x","article-title":"Specific circulating microRNA signature of bicuspid aortic valve disease.","volume":"15","author":"Mart\u00ednez-Micaelo","year":"2017","journal-title":"J Transl Med"},{"issue":"25","key":"joi200146r11","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1016\/j.jacc.2009.12.068","article-title":"Bicuspid aortic valve disease.","volume":"55","author":"Siu","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"joi200146r12","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1001\/jama.300.11.1317","article-title":"Outcomes in adults with bicuspid aortic valves.","volume":"300","author":"Tzemos","year":"2008","journal-title":"JAMA"},{"issue":"21","key":"joi200146r13","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","article-title":"Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community.","volume":"117","author":"Michelena","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"joi200146r14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10654-018-0448-y","article-title":"Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion.","volume":"34","author":"Sillesen","year":"2019","journal-title":"Eur J Epidemiol"},{"issue":"7","key":"joi200146r15","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.echo.2019.02.015","article-title":"Repeatability and reproducibility of neonatal echocardiography: the Copenhagen Baby Heart Study.","volume":"32","author":"Sillesen","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"issue":"12","key":"joi200146r16","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/j.echo.2006.09.001","article-title":"Guidelines and standards for performance of a pediatric echocardiogram: a report from the Task Force of the Pediatric Council of the American Society of Echocardiography.","volume":"19","author":"Lai","year":"2006","journal-title":"J Am Soc Echocardiogr"},{"issue":"5","key":"joi200146r17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.echo.2010.03.019","article-title":"Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council.","volume":"23","author":"Lopez","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"issue":"8","key":"joi200146r18","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Two-sided confidence intervals for the single proportion: comparison of seven methods.","volume":"17","author":"Newcombe","year":"1998","journal-title":"Stat Med"},{"issue":"11","key":"joi200146r19","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.006979","article-title":"Relationship of echocardiographic Z scores adjusted for body surface area to age, sex, race, and ethnicity: the Pediatric Heart Network Normal Echocardiogram Database.","volume":"10","author":"Lopez","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"joi200146r20","article-title":"Pediatric Heart Network echocardiographic Z scores: comparison with other published models.","author":"Lopez","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"issue":"83","key":"joi200146r21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/qjmed\/os-21.83.383","volume":"21","author":"Wauchope","year":"1928","journal-title":"QJM Int J Med"},{"issue":"6","key":"joi200146r22","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0002-9149(84)90418-1","article-title":"Risk factors for aortic dissection: a necropsy study of 161 cases.","volume":"53","author":"Larson","year":"1984","journal-title":"Am J Cardiol"},{"issue":"5","key":"joi200146r23","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1536\/ihj.29.661","article-title":"Anatomically isolated aortic valve disease: morphologic study of 100 cases at autopsy.","volume":"29","author":"Datta","year":"1988","journal-title":"Jpn Heart J"},{"issue":"1","key":"joi200146r24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/0002-9149(70)90761-7","article-title":"The congenitally bicuspid aortic valve: a study of 85 autopsy cases.","volume":"26","author":"Roberts","year":"1970","journal-title":"Am J Cardiol"},{"issue":"5","key":"joi200146r25","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1017\/S1047951100005400","article-title":"The aortic valve with two leaflets\u2014a study in 2,000 autopsies.","volume":"9","author":"Pauperio","year":"1999","journal-title":"Cardiol Young"},{"issue":"1","key":"joi200146r26","first-page":"48","article-title":"Reliability of transthoracic echocardiography in the assessment of aortic valve morphology: pathological correlation in 178 patients.","volume":"15","author":"Chan","year":"1999","journal-title":"Can J Cardiol"},{"issue":"5","key":"joi200146r27","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.amjcard.2003.11.031","article-title":"An echocardiographic survey of primary school children for bicuspid aortic valve.","volume":"93","author":"Basso","year":"2004","journal-title":"Am J Cardiol"},{"issue":"3","key":"joi200146r28","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ahj.2004.10.036","article-title":"The prevalence of bicuspid aortic valve in newborns by echocardiographic screening.","volume":"150","author":"Tutar","year":"2005","journal-title":"Am Heart J"},{"issue":"10","key":"joi200146r29","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004211","article-title":"Sex differences and survival in adults with bicuspid aortic valves: verification in 3 contemporary echocardiographic cohorts.","volume":"5","author":"Michelena","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"joi200146r30","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1001\/jamacardio.2016.5228","article-title":"Prognostic implications of raphe in bicuspid aortic valve anatomy.","volume":"2","author":"Kong","year":"2017","journal-title":"JAMA Cardiol"},{"issue":"6","key":"joi200146r31","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1016\/j.athoracsur.2015.02.036","article-title":"The association between aortic valve leaflet morphology and patterns of aortic dilation in patients with bicuspid aortic valves.","volume":"99","author":"Ruzmetov","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"12","key":"joi200146r32","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease.","volume":"39","author":"Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"joi200146r33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4103\/apc.APC_171_17","article-title":"Percutaneous balloon dilatation for congenital aortic stenosis during infancy: a 15-year single-center experience.","volume":"11","author":"Jijeh","year":"2018","journal-title":"Ann Pediatr Cardiol"},{"issue":"1","key":"joi200146r34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0003-4975(03)01249-9","article-title":"The congenitally bicuspid aortic valve: how does it function? why does it fail?","volume":"77","author":"Robicsek","year":"2004","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"joi200146r35","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jpeds.2010.03.004","article-title":"Outcome of isolated bicuspid aortic valve in childhood.","volume":"157","author":"Mahle","year":"2010","journal-title":"J Pediatr"},{"issue":"1","key":"joi200146r36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.amjcard.2017.03.245","article-title":"Aortic diameter growth in children with a bicuspid aortic valve.","volume":"120","author":"Merkx","year":"2017","journal-title":"Am J Cardiol"},{"key":"joi200146r37","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ijcard.2017.09.168","article-title":"Bicuspid aortic valve: a complex aortopathy rather than a simple valvulopathy.","volume":"250","author":"Gelpi","year":"2018","journal-title":"Int J Cardiol"},{"issue":"10","key":"joi200146r38","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.jcmg.2012.07.008","article-title":"Bicuspid aortic valve: inter-racial difference in frequency and aortic dimensions.","volume":"5","author":"Chandra","year":"2012","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2776200\/jama_sillesen_2021_oi_200146_1612545214.2497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T12:44:35Z","timestamp":1612961075000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2776200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2020.27205","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,9]]}}}