{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:29:01Z","timestamp":1793104141446,"version":"4.5.0"},"reference-count":24,"publisher":"American Medical Association (AMA)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2021,10,19]]},"DOI":"10.1001\/jama.2021.15703","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T23:28:48Z","timestamp":1634772528000},"page":"1494","source":"Crossref","is-referenced-by-count":83,"title":["Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest"],"prefix":"10.1001","volume":"326","author":[{"given":"Michel","family":"Le May","sequence":"first","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Osborne","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Russo","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"So","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aun Yeong","family":"Chong","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dick","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Froeschl","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Glover","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hibbert","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Marquis","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"De Roock","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Labinaz","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Bernick","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Marshall","sequence":"additional","affiliation":[{"name":"University of Ottawa, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnen","family":"Maze","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Wells","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"},{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"3","key":"joi210104r1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.resuscitation.2008.10.034","article-title":"Cognitive impairments in survivors of out-of-hospital cardiac arrest: a systematic review.","volume":"80","author":"Moulaert","year":"2009","journal-title":"Resuscitation"},{"issue":"8","key":"joi210104r2","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.","volume":"346","author":"Hypothermia After Cardiac Arrest Study Group","year":"2002","journal-title":"N Engl J Med"},{"issue":"8","key":"joi210104r3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med"},{"issue":"24","key":"joi210104r4","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1056\/NEJMoa1906661","article-title":"Targeted temperature management for cardiac arrest with nonshockable rhythm.","volume":"381","author":"Lascarrou","year":"2019","journal-title":"N Engl J Med"},{"issue":"23","key":"joi210104r5","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33\u00b0C versus 36\u00b0C after cardiac arrest.","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"issue":"16","key":"joi210104r6","first-page":"S92","article-title":"Adult Advanced Life Support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations.","volume":"142","author":"Berg","year":"2020","journal-title":"Circulation"},{"issue":"4","key":"joi210104r7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00134-021-06368-4","article-title":"European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.","volume":"47","author":"Nolan","year":"2021","journal-title":"Intensive Care Med"},{"issue":"16","key":"joi210104r8","first-page":"S366","article-title":"Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care.","volume":"142","author":"Panchal","year":"2020","journal-title":"Circulation"},{"key":"joi210104r9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1213\/00000539-195911000-00010","article-title":"The use of hypothermia after cardiac arrest.","volume":"38","author":"Benson","year":"1959","journal-title":"Anesth Analg"},{"issue":"11","key":"joi210104r10","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1161\/01.STR.21.11.1600","article-title":"Moderate hypothermia after cardiac arrest of 17 minutes in dogs: effect on cerebral and cardiac outcome.","volume":"21","author":"Leonov","year":"1990","journal-title":"Stroke"},{"issue":"24","key":"joi210104r11","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.1161\/CIRCULATIONAHA.112.136408","article-title":"Hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing 2 levels of target temperature.","volume":"126","author":"Lopez-de-Sa","year":"2012","journal-title":"Circulation"},{"issue":"10","key":"joi210104r12","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.resuscitation.2014.05.029","article-title":"Endovascular cooling catheter related thrombosis in patients undergoing therapeutic hypothermia for out of hospital cardiac arrest.","volume":"85","author":"Maze","year":"2014","journal-title":"Resuscitation"},{"issue":"2","key":"joi210104r13","first-page":"94","article-title":"Reliability and validity of the Disability Rating Scale and the Levels of Cognitive Functioning Scale in monitoring recovery from severe head injury.","volume":"68","author":"Gouvier","year":"1987","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"joi210104r14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5005\/jp-journals-10071-23107","article-title":"Long-term survival and functional neurological outcome in conscious hospital survivors undergoing therapeutic hypothermia.","volume":"23","author":"Kongpolprom","year":"2019","journal-title":"Indian J Crit Care Med"},{"issue":"5","key":"joi210104r15","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1177\/003693305700200504","article-title":"Cerebral vascular accidents in patients over the age of 60, II: prognosis.","volume":"2","author":"Rankin","year":"1957","journal-title":"Scott Med J"},{"issue":"5","key":"joi210104r16","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver agreement for the assessment of handicap in stroke patients.","volume":"19","author":"van Swieten","year":"1988","journal-title":"Stroke"},{"issue":"2","key":"joi210104r17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.110.986257","article-title":"Therapeutic hypothermia after out-of-hospital cardiac arrest: evaluation of a regional system to increase access to cooling.","volume":"124","author":"Mooney","year":"2011","journal-title":"Circulation"},{"issue":"11","key":"joi210104r18","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1007\/s00134-018-5256-z","article-title":"A multicentre randomized pilot trial on the effectiveness of different levels of cooling in comatose survivors of out-of-hospital cardiac arrest: the FROST-I trial.","volume":"44","author":"Lopez-de-Sa","year":"2018","journal-title":"Intensive Care Med"},{"issue":"4","key":"joi210104r19","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1001\/jama.2017.8978","article-title":"Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial.","volume":"318","author":"Kirkegaard","year":"2017","journal-title":"JAMA"},{"issue":"1","key":"joi210104r20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13613-019-0603-y","article-title":"Targeted temperature management guided by the severity of hyperlactatemia for out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry.","volume":"9","author":"Okazaki","year":"2019","journal-title":"Ann Intensive Care"},{"issue":"5","key":"joi210104r21","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.resuscitation.2011.11.019","article-title":"The beneficial effect of mild therapeutic hypothermia depends on the time of complete circulatory standstill in patients with cardiac arrest.","volume":"83","author":"Testori","year":"2012","journal-title":"Resuscitation"},{"key":"joi210104r22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.resuscitation.2015.09.400","article-title":"Limited effect of mild therapeutic hypothermia on outcome after prolonged resuscitation.","volume":"98","author":"Wallm\u00fcller","year":"2016","journal-title":"Resuscitation"},{"key":"joi210104r23","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.resuscitation.2018.03.021","article-title":"ILCOR scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care: a consensus statement.","volume":"127","author":"Kleinman","year":"2018","journal-title":"Resuscitation"},{"issue":"24","key":"joi210104r24","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1056\/NEJMoa2100591","article-title":"Hypothermia versus normothermia after out-of-hospital cardiac arrest.","volume":"384","author":"Dankiewicz","year":"2021","journal-title":"N Engl J Med"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2785263\/jama_le_may_2021_oi_210104_1633987816.98054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T23:28:53Z","timestamp":1634772533000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2785263"}},"subtitle":["The CAPITAL CHILL Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":24,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,10,19]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2021.15703","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,19]]}}}