{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:35:49Z","timestamp":1791596149992,"version":"4.3.4"},"reference-count":52,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2022,1,25]]},"DOI":"10.1001\/jama.2021.21811","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T16:01:42Z","timestamp":1643126502000},"page":"368","source":"Crossref","is-referenced-by-count":56,"title":["Screening for Atrial Fibrillation"],"prefix":"10.1001","volume":"327","author":[{"given":"Leila C.","family":"Kahwati","sequence":"first","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary N.","family":"Asher","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Department of Family Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary O.","family":"Kadro","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Department of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Keen","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Department of Family Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Ali","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Coker-Schwimmer","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Department of Internal Medicine, The Ohio State University College of Medicine, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Jonas","sequence":"additional","affiliation":[{"name":"RTI International\u2013University of North Carolina at Chapel Hill Evidence-based Practice Center"},{"name":"Department of Internal Medicine, The Ohio State University College of Medicine, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"9","key":"jus210029r1","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American Heart Association.","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"issue":"9989","key":"jus210029r2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0140-6736(14)61774-8","article-title":"50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study.","volume":"386","author":"Schnabel","year":"2015","journal-title":"Lancet"},{"issue":"9","key":"jus210029r3","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.117.309732","article-title":"Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes.","volume":"120","author":"Staerk","year":"2017","journal-title":"Circ Res"},{"issue":"12","key":"jus210029r4","doi-asserted-by":"publisher","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.","volume":"146","author":"Hart","year":"2007","journal-title":"Ann Intern Med"},{"issue":"21","key":"jus210029r5","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"jus210029r6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/jama.2018.10321","article-title":"Screening for atrial fibrillation with electrocardiography: US Preventive Services Task Force recommendation statement.","volume":"320","author":"Curry","year":"2018","journal-title":"JAMA"},{"key":"jus210029r10","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials.","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"3","key":"jus210029r11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials.","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"11","key":"jus210029r12","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Quantifying heterogeneity in a meta-analysis.","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"7414","key":"jus210029r13","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses.","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"40","key":"jus210029r15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3310\/hta9400","article-title":"A randomised controlled trial and cost-effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in people aged 65 and over: the SAFE study.","volume":"9","author":"Hobbs","year":"2005","journal-title":"Health Technol Assess"},{"issue":"3","key":"jus210029r16","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/fampra\/cmu011","article-title":"Is screening for AF worthwhile? stroke risk in a screened population from the SAFE study.","volume":"31","author":"Fitzmaurice","year":"2014","journal-title":"Fam Pract"},{"issue":"7616","key":"jus210029r17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/bmj.39280.660567.55","article-title":"Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: cluster randomised controlled trial.","volume":"335","author":"Fitzmaurice","year":"2007","journal-title":"BMJ"},{"issue":"7616","key":"jus210029r18","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1136\/bmj.39227.551713.AE","article-title":"Accuracy of diagnosing atrial fibrillation on electrocardiogram by primary care practitioners and interpretative diagnostic software: analysis of data from screening for atrial fibrillation in the elderly (SAFE) trial.","volume":"335","author":"Mant","year":"2007","journal-title":"BMJ"},{"key":"jus210029r19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2261-4-12","article-title":"A randomised controlled trial and cost effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in the over 65s: (SAFE) [ISRCTN19633732].","volume":"4","author":"Swancutt","year":"2004","journal-title":"BMC Cardiovasc Disord"},{"issue":"4","key":"jus210029r20","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1161\/STROKEAHA.108.526988","article-title":"Effect of age on stroke prevention therapy in patients with atrial fibrillation: the atrial fibrillation investigators.","volume":"40","author":"van Walraven","year":"2009","journal-title":"Stroke"},{"issue":"20","key":"jus210029r21","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1056\/NEJM199211123272002","article-title":"Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation.","volume":"327","author":"Ezekowitz","year":"1992","journal-title":"N Engl J Med"},{"issue":"2","key":"jus210029r22","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1161\/01.CIR.84.2.527","article-title":"Stroke Prevention in Atrial Fibrillation Study: final results.","volume":"84","year":"1991","journal-title":"Circulation"},{"issue":"2","key":"jus210029r23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0735-1097(91)90585-W","article-title":"Canadian Atrial Fibrillation Anticoagulation (CAFA) study.","volume":"18","author":"Connolly","year":"1991","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"jus210029r24","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1056\/NEJM199011293232201","article-title":"The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation.","volume":"323","author":"Singer","year":"1990","journal-title":"N Engl J Med"},{"issue":"12","key":"jus210029r25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1056\/NEJM199003223221232","article-title":"Preliminary report of the Stroke Prevention in Atrial Fibrillation Study.","volume":"322","author":"Stroke Prevention in Atrial Fibrillation Study Group Investigators","year":"1990","journal-title":"N Engl J Med"},{"issue":"8631","key":"jus210029r26","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0140-6736(89)91200-2","article-title":"Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation: the Copenhagen AFASAK study.","volume":"1","author":"Petersen","year":"1989","journal-title":"Lancet"},{"issue":"1","key":"jus210029r27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/ijcp.2011.66.issue-1","article-title":"Effect of pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation.","volume":"66","author":"Coleman","year":"2012","journal-title":"Int J Clin Pract"},{"issue":"3","key":"jus210029r28","article-title":"Oral anticoagulants for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks.","author":"Aguilar","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"478","key":"jus210029r29","first-page":"373","article-title":"Randomised trial of two approaches to screening for atrial fibrillation in UK general practice.","volume":"52","author":"Morgan","year":"2002","journal-title":"Br J Gen Pract"},{"issue":"5","key":"jus210029r30","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003206","article-title":"Comparative effectiveness of interventions for stroke prevention in atrial fibrillation: a network meta-analysis.","volume":"5","author":"Tereshchenko","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"13","key":"jus210029r31","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1001\/archinte.1994.00420130036007","article-title":"Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials.","volume":"154","year":"1994","journal-title":"Arch Intern Med"},{"issue":"19","key":"jus210029r32","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.117.030583","article-title":"Assessment of remote heart rhythm sampling using the AliveCor heart monitor to screen for atrial fibrillation: the REHEARSE-AF study.","volume":"136","author":"Halcox","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"jus210029r33","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1001\/jama.2018.8102","article-title":"Effect of a home-based wearable continuous ECG monitoring patch on detection of undiagnosed atrial fibrillation: the mSToPS randomized clinical trial.","volume":"320","author":"Steinhubl","year":"2018","journal-title":"JAMA"},{"issue":"13","key":"jus210029r34","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.jacep.2017.06.020","article-title":"Detection of subclinical atrial fibrillation in high-risk patients using an insertable cardiac monitor.","volume":"3","author":"Philippsen","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"issue":"1","key":"jus210029r35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191592","article-title":"Risk factors for death, stroke, and bleeding in 28,628 patients from the GARFIELD-AF registry: rationale for comprehensive management of atrial fibrillation.","volume":"13","author":"Bassand","year":"2018","journal-title":"PLoS One"},{"issue":"695","key":"jus210029r36","doi-asserted-by":"publisher","first-page":"e427","DOI":"10.3399\/bjgp20X708161","article-title":"Opportunistic screening versus usual care for diagnosing atrial fibrillation in general practice: a cluster randomised controlled trial.","volume":"70","author":"Kaasenbrood","year":"2020","journal-title":"Br J Gen Pract"},{"issue":"5","key":"jus210029r37","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1370\/afm.2438","article-title":"Diagnostic accuracy of a smartphone-operated, single-lead electrocardiography device for detection of rhythm and conduction abnormalities in primary care.","volume":"17","author":"Himmelreich","year":"2019","journal-title":"Ann Fam Med"},{"issue":"5","key":"jus210029r38","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004565","article-title":"Triage tests for identifying atrial fibrillation in primary care: a diagnostic accuracy study comparing single-lead ECG and modified BP monitors.","volume":"4","author":"Kearley","year":"2014","journal-title":"BMJ Open"},{"issue":"7","key":"jus210029r39","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.amjcard.2014.07.016","article-title":"Comparison of the Microlife blood pressure monitor with the Omron blood pressure monitor for detecting atrial fibrillation.","volume":"114","author":"Wiesel","year":"2014","journal-title":"Am J Cardiol"},{"issue":"1","key":"jus210029r40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12325-011-0087-0","article-title":"Comparison of Microlife BP A200 Plus and Omron M6 blood pressure monitors to detect atrial fibrillation in hypertensive patients.","volume":"29","author":"Marazzi","year":"2012","journal-title":"Adv Ther"},{"key":"jus210029r41","doi-asserted-by":"crossref","first-page":"m3208","DOI":"10.1136\/bmj.m3208","article-title":"Opportunistic screening versus usual care for detection of atrial fibrillation in primary care: cluster randomised controlled trial.","volume":"370","author":"Uittenbogaart","year":"2020","journal-title":"BMJ"},{"issue":"10","key":"jus210029r42","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1111\/pace.v42.10","article-title":"A study to assess a novel automated electrocardiogram technology in screening for atrial fibrillation.","volume":"42","author":"Sabar","year":"2019","journal-title":"Pacing Clin Electrophysiol"},{"issue":"5","key":"jus210029r43","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1001\/jamacardio.2021.0038","article-title":"Screening for atrial fibrillation in the older population: a randomized clinical trial.","volume":"6","author":"Gladstone","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"10310","key":"jus210029r44","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/S0140-6736(21)01637-8","article-title":"Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial.","volume":"398","author":"Svennberg","year":"2021","journal-title":"Lancet"},{"issue":"25","key":"jus210029r45","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1161\/CIRCULATIONAHA.114.014343","article-title":"Mass screening for untreated atrial fibrillation: the STROKESTOP study.","volume":"131","author":"Svennberg","year":"2015","journal-title":"Circulation"},{"issue":"7","key":"jus210029r46","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/ejhf.291","article-title":"New echocardiographic predictors of clinical outcome in patients presenting with heart failure and a preserved left ventricular ejection fraction: a subanalysis of the Ka (Karolinska) Ren (Rennes) study.","volume":"17","author":"Donal","year":"2015","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"jus210029r47","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/europace\/eus217","article-title":"Population screening of 75- and 76-year-old men and women for silent atrial fibrillation (STROKESTOP).","volume":"15","author":"Friberg","year":"2013","journal-title":"Europace"},{"issue":"6","key":"jus210029r48","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1253\/circj.CJ-11-1206","article-title":"Heparin bridging vs. uninterrupted oral anticoagulation in patients with atrial fibrillation undergoing coronary artery stenting: results from the AFCAS registry.","volume":"76","author":"Lahtela","year":"2012","journal-title":"Circ J"},{"issue":"23","key":"jus210029r49","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1161\/CIRCULATIONAHA.117.026229","article-title":"Composite end points in clinical research: a time for reappraisal.","volume":"135","author":"Armstrong","year":"2017","journal-title":"Circulation"},{"issue":"9","key":"jus210029r50","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/anae.2016.71.issue-9","article-title":"The case of the misleading composite\u2014one outcome is better than two.","volume":"71","author":"Choi","year":"2016","journal-title":"Anaesthesia"},{"issue":"1","key":"jus210029r51","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1161\/CIRCOUTCOMES.113.000149","article-title":"Informed choice of composite end points in cardiovascular trials.","volume":"7","author":"G\u00f3mez","year":"2014","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"9","key":"jus210029r52","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.amjmed.2004.06.024","article-title":"Misdiagnosis of atrial fibrillation and its clinical consequences.","volume":"117","author":"Bogun","year":"2004","journal-title":"Am J Med"},{"key":"jus210029r7","volume-title":"Screening for Atrial Fibrillation: An Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 208","author":"Kahwati","year":"2021"},{"key":"jus210029r8","unstructured":"Statistical update 2018: human development indices and indicators. United Nations Development Programme. Published 2018. Accessed November 22, 2021. http:\/\/hdr.undp.org\/en\/content\/human-development-indices-indicators-2018-statistical-update"},{"key":"jus210029r9","unstructured":"Procedure Manual Appendix VI: Criteria for assessing internal validity of individual studies. US Preventive Services Task Force. Published May 2021. Accessed November 22, 2021. https:\/\/www.uspreventiveservicestaskforce.org\/uspstf\/about-uspstf\/methods-and-processes\/procedure-manual\/procedure-manual-appendix-vi-criteria-assessing-internal-validity-individual-studies"},{"key":"jus210029r14","unstructured":"Procedure Manual Appendix XII: Summary of evidence table for evidence reviews. US Preventive Services Task Force. Published May 2021. Accessed November 22, 2021. https:\/\/www.uspreventiveservicestaskforce.org\/uspstf\/about-uspstf\/methods-and-processes\/procedure-manual\/procedure-manual-appendix-xii-summary-evidence-table-evidence-reviews"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2788341\/jama_kahwati_2022_us_210029_1643049422.02354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T16:01:52Z","timestamp":1643126512000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2788341"}},"subtitle":["Updated Evidence Report and Systematic Review for the US Preventive Services Task Force"],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,1,25]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2021.21811","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,25]]}}}