{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:34:31Z","timestamp":1793637271549,"version":"4.5.1"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2022,8,2]]},"DOI":"10.1001\/jama.2022.11390","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T11:45:26Z","timestamp":1659440726000},"page":"440","source":"Crossref","is-referenced-by-count":242,"title":["Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout"],"prefix":"10.1001","volume":"328","author":[{"given":"Edoardo","family":"Cipolletta","sequence":"first","affiliation":[{"name":"Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom"},{"name":"Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila J.","family":"Tata","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Nakafero","sequence":"additional","affiliation":[{"name":"Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Avery","sequence":"additional","affiliation":[{"name":"Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University, Keele, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Abhishek","sequence":"additional","affiliation":[{"name":"Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"25","key":"joi220073r1","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: update from the GBD 2019 study.","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"joi220073r2","doi-asserted-by":"publisher","first-page":"II2","DOI":"10.1161\/circ.109.21.2475","article-title":"Inflammation as a cardiovascular risk factor.","volume":"109","author":"Willerson","year":"2004","journal-title":"Circulation"},{"issue":"7","key":"joi220073r3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors.","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"joi220073r4","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/art.2019.71.issue-6","article-title":"Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the National Health and Nutrition Examination Survey, 2007-2016.","volume":"71","author":"Chen-Xu","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"10287","key":"joi220073r5","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout.","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet"},{"issue":"6","key":"joi220073r6","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1136\/ard.2009.122770","article-title":"Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based study.","volume":"69","author":"De Vera","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"joi220073r7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.107.703389","article-title":"Independent impact of gout on mortality and risk for coronary heart disease.","volume":"116","author":"Choi","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"joi220073r8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/rheumatology\/kes169","article-title":"Risk of myocardial infarction among patients with gout: a nationwide population-based study.","volume":"52","author":"Kuo","year":"2013","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"joi220073r9","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1002\/(ISSN)1529-0131","article-title":"Gout and the risk of acute myocardial infarction.","volume":"54","author":"Krishnan","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"1","key":"joi220073r10","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1016\/S2665-9913(20)30221-6","article-title":"Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout.","volume":"3","author":"Hansildaar","year":"2021","journal-title":"Lancet Rheumatol"},{"issue":"12","key":"joi220073r11","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease.","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"issue":"3","key":"joi220073r12","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ije\/dyv098","article-title":"Data resource profile: Clinical Practice Research Datalink (CPRD).","volume":"44","author":"Herrett","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"4","key":"joi220073r13","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1136\/annrheumdis-2013-204463","article-title":"Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study.","volume":"74","author":"Kuo","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"joi220073r14","doi-asserted-by":"publisher","first-page":"f2350","DOI":"10.1136\/bmj.f2350","article-title":"Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study.","volume":"346","author":"Herrett","year":"2013","journal-title":"BMJ"},{"issue":"2","key":"joi220073r15","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPO.2020.0117","article-title":"Concordance in the recording of stroke across UK primary and secondary care datasets: a population-based cohort study.","volume":"5","author":"Morgan","year":"2021","journal-title":"BJGP Open"},{"issue":"10","key":"joi220073r16","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1136\/emj.2010.095885","article-title":"Incidence of acute myocardial infarction resulting in sudden death outside the hospital.","volume":"28","author":"Adnet","year":"2011","journal-title":"Emerg Med J"},{"issue":"2","key":"joi220073r17","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/BOR.0b013e3283438e13","article-title":"Risk factors for gout and prevention: a systematic review of the literature.","volume":"23","author":"Singh","year":"2011","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"joi220073r18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/EDE.0b013e3182093a0f","article-title":"Time-window bias in case-control studies: statins and lung cancer.","volume":"22","author":"Suissa","year":"2011","journal-title":"Epidemiology"},{"issue":"1","key":"joi220073r19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2288-5-5","article-title":"Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure.","volume":"5","author":"Essebag","year":"2005","journal-title":"BMC Med Res Methodol"},{"issue":"11","key":"joi220073r20","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/acr.v66.11","article-title":"Using natural language processing and machine learning to identify gout flares from electronic clinical notes.","volume":"66","author":"Zheng","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"5","key":"joi220073r21","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1093\/rheumatology\/keq363","article-title":"Frequency and risk factors of gout flares in a large population-based cohort of incident gout.","volume":"50","author":"Rothenbacher","year":"2011","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"joi220073r22","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/pds.v25.7","article-title":"Validation of claims-based algorithms for gout flares.","volume":"25","author":"MacFarlane","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"joi220073r23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2296-11-1","article-title":"Adaptation and validation of the Charlson Index for Read\/OXMIS coded databases.","volume":"11","author":"Khan","year":"2010","journal-title":"BMC Fam Pract"},{"issue":"1","key":"joi220073r24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"key":"joi220073r25","doi-asserted-by":"publisher","first-page":"i4515","DOI":"10.1136\/bmj.i4515","article-title":"Self controlled case series methods: an alternative to standard epidemiological study designs.","volume":"354","author":"Petersen","year":"2016","journal-title":"BMJ"},{"issue":"10","key":"joi220073r26","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.jclinepi.2006.01.009","article-title":"Using the outcome for imputation of missing predictor values was preferred.","volume":"59","author":"Moons","year":"2006","journal-title":"J Clin Epidemiol"},{"issue":"4","key":"joi220073r27","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/sim.v30.4","article-title":"Multiple imputation using chained equations: issues and guidance for practice.","volume":"30","author":"White","year":"2011","journal-title":"Stat Med"},{"issue":"20","key":"joi220073r28","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e133","article-title":"Seasonal variations and associated factors of gout attacks: a prospective multicenter study in Korea.","volume":"35","author":"Choi","year":"2020","journal-title":"J Korean Med Sci"},{"issue":"7081","key":"joi220073r29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome.","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"issue":"1","key":"joi220073r30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1056\/NEJMoa012295","article-title":"Widespread coronary inflammation in unstable angina.","volume":"347","author":"Buffon","year":"2002","journal-title":"N Engl J Med"},{"issue":"23","key":"joi220073r31","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1161\/01.CIR.0000042674.89762.20","article-title":"Neutrophil infiltration of culprit lesions in acute coronary syndromes.","volume":"106","author":"Naruko","year":"2002","journal-title":"Circulation"},{"issue":"9","key":"joi220073r32","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1161\/ATVBAHA.110.209296","article-title":"High neutrophil numbers in human carotid atherosclerotic plaques are associated with characteristics of rupture-prone lesions.","volume":"30","author":"Ionita","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"joi220073r33","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1056\/NEJMra1808137","article-title":"Acute infection and myocardial infarction.","volume":"380","author":"Musher","year":"2019","journal-title":"N Engl J Med"},{"issue":"22","key":"joi220073r34","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1016\/j.jacc.2014.09.034","article-title":"New-onset atrial fibrillation during hospitalization.","volume":"64","author":"Walkey","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"joi220073r35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1136\/annrheumdis-2012-202421","article-title":"Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout.","volume":"73","author":"Perez-Ruiz","year":"2014","journal-title":"Ann Rheum Dis"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2794763\/jama_cipolletta_2022_oi_220073_1659390396.55852.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T11:45:29Z","timestamp":1659440729000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2794763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,8,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2022.11390","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,2]]}}}