{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:22:47Z","timestamp":1791728567052,"version":"4.3.4"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2022,4,12]]},"DOI":"10.1001\/jama.2022.2896","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T17:30:41Z","timestamp":1649093441000},"page":"1368","source":"Crossref","is-referenced-by-count":50,"title":["Association of Transthyretin Val122Ile Variant With Incident Heart Failure Among Black Individuals"],"prefix":"10.1001","volume":"327","author":[{"given":"Vibhu","family":"Parcha","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Disease, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargya","family":"Malla","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite R.","family":"Irvin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E.","family":"Judd","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Lange","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine, University of Colorado, Aurora"},{"name":"Department of Epidemiology, School of Public Health, University of Colorado, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily B.","family":"Levitan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, University of Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, University of Alabama, Birmingham"},{"name":"Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"joi220024r1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004769","article-title":"TTR (transthyretin) stabilizers are associated with improved survival in patients with TTR cardiac amyloidosis.","volume":"11","author":"Rosenblum","year":"2018","journal-title":"Circ Heart Fail"},{"issue":"10","key":"joi220024r2","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1161\/CIRCULATIONAHA.111.078915","article-title":"Transthyretin (TTR) cardiac amyloidosis.","volume":"126","author":"Ruberg","year":"2012","journal-title":"Circulation"},{"issue":"7","key":"joi220024r3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/nrcardio.2010.67","article-title":"Transthyretin-related amyloidoses and the heart: a clinical overview.","volume":"7","author":"Rapezzi","year":"2010","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"joi220024r4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3109\/13506129.2015.1051219","article-title":"Prevalence of the amyloidogenic transthyretin (TTR) V122I allele in 14?333 African-Americans.","volume":"22","author":"Jacobson","year":"2015","journal-title":"Amyloid"},{"issue":"7","key":"joi220024r5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/gim.2016.200","article-title":"Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans.","volume":"19","author":"Buxbaum","year":"2017","journal-title":"Genet Med"},{"issue":"22","key":"joi220024r6","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2019.17935","article-title":"Association of the V122I hereditary transthyretin amyloidosis genetic variant with heart failure among individuals of African or Hispanic\/Latino ancestry.","volume":"322","author":"Damrauer","year":"2019","journal-title":"JAMA"},{"issue":"1","key":"joi220024r7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1056\/NEJMoa1404852","article-title":"The amyloidogenic V122I transthyretin variant in elderly black Americans.","volume":"372","author":"Quarta","year":"2015","journal-title":"N Engl J Med"},{"issue":"5","key":"joi220024r8","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.ahj.2010.02.006","article-title":"Significance of the amyloidogenic transthyretin Val 122 Ile allele in African Americans in the Arteriosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) studies.","volume":"159","author":"Buxbaum","year":"2010","journal-title":"Am Heart J"},{"issue":"8","key":"joi220024r9","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/s41436-021-01172-3","article-title":"ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG).","volume":"23","author":"Miller","year":"2021","journal-title":"Genet Med"},{"issue":"11","key":"joi220024r10","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy.","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"issue":"3","key":"joi220024r11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000086678","article-title":"The Reasons for Geographic and Racial Differences in Stroke study: objectives and design.","volume":"25","author":"Howard","year":"2005","journal-title":"Neuroepidemiology"},{"issue":"1","key":"joi220024r12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12874-019-0890-x","article-title":"Assembling and validating a heart failure-free cohort from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.","volume":"20","author":"Goyal","year":"2020","journal-title":"BMC Med Res Methodol"},{"key":"joi220024r13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12920-018-0462-7","article-title":"A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study.","volume":"12","author":"Zhao","year":"2019","journal-title":"BMC Med Genomics"},{"issue":"8","key":"joi220024r14","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies.","volume":"38","author":"Price","year":"2006","journal-title":"Nat Genet"},{"issue":"9","key":"joi220024r15","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals.","volume":"19","author":"Alexander","year":"2009","journal-title":"Genome Res"},{"key":"joi220024r16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets.","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"issue":"5","key":"joi220024r17","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.cardfail.2021.01.011","article-title":"The Dietary Approaches to Stop Hypertension (DASH) diet pattern and incident heart failure.","volume":"27","author":"Goyal","year":"2021","journal-title":"J Card Fail"},{"issue":"12","key":"joi220024r18","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1093\/aje\/kwh314","article-title":"Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women\u2019s Health Initiative.","volume":"160","author":"Heckbert","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"5","key":"joi220024r19","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jchf.2019.01.016","article-title":"Association of urine albumin excretion with incident heart failure hospitalization in community-dwelling adults.","volume":"7","author":"Bailey","year":"2019","journal-title":"JACC Heart Fail"},{"issue":"17","key":"joi220024r20","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1001\/jama.2012.14306","article-title":"Association of race and sex with risk of incident acute coronary heart disease events.","volume":"308","author":"Safford","year":"2012","journal-title":"JAMA"},{"issue":"9","key":"joi220024r21","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"7","key":"joi220024r22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179234","article-title":"Methods to estimate underlying blood pressure: the Atherosclerosis Risk in Communities (ARIC) study.","volume":"12","author":"Balakrishnan","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"joi220024r23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1056\/NEJM200107123450205","article-title":"Neighborhood of residence and incidence of coronary heart disease.","volume":"345","author":"Diez Roux","year":"2001","journal-title":"N Engl J Med"},{"key":"joi220024r24","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1186\/1471-2458-14-1319","article-title":"Associations of neighborhood area level deprivation with the metabolic syndrome and inflammation among middle- and older- age adults.","volume":"14","author":"Keita","year":"2014","journal-title":"BMC Public Health"},{"issue":"7","key":"joi220024r25","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018689","article-title":"Obesity and serial NT-proBNP levels in guided medical therapy for heart failure with reduced ejection fraction: insights from the GUIDE-IT trial.","volume":"10","author":"Parcha","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"joi220024r26","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1161\/CIRCULATIONAHA.120.046374","article-title":"Racial differences in serial NT-proBNP levels in heart failure management: insights from the GUIDE-IT trial.","volume":"142","author":"Parcha","year":"2020","journal-title":"Circulation"},{"issue":"1","key":"joi220024r27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1001\/jamacardio.2017.4207","article-title":"Racial differences in plasma levels of N-terminal pro-B-type natriuretic peptide and outcomes: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.","volume":"3","author":"Bajaj","year":"2018","journal-title":"JAMA Cardiol"},{"key":"joi220024r28","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129979","article-title":"Racial differences in the association of NT-proBNP with risk of incident heart failure in REGARDS.","author":"Patel","journal-title":"JCI Insight"},{"key":"joi220024r29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijcard.2019.02.034","article-title":"Race-based demographic, anthropometric and clinical correlates of N-terminal-pro B-type natriuretic peptide.","volume":"286","author":"Patel","year":"2019","journal-title":"Int J Cardiol"},{"issue":"3","key":"joi220024r30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1056\/NEJMoa1803180","article-title":"Effect of systolic and diastolic blood pressure on cardiovascular outcomes.","volume":"381","author":"Flint","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"joi220024r31","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.mayocp.2020.08.036","article-title":"Geographic inequalities in cardiovascular mortality in the United States: 1999 to 2018.","volume":"96","author":"Parcha","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"7","key":"joi220024r32","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/j.mayocp.2020.12.034","article-title":"Geographic variation in cardiovascular health among American adults.","volume":"96","author":"Parcha","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"joi220024r33","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.mayocpiqo.2020.09.005","article-title":"Geographic variation in racial disparities in health and coronavirus disease-2019 (COVID-19) mortality.","volume":"4","author":"Parcha","year":"2020","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"issue":"2","key":"joi220024r34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jaccao.2019.11.006","article-title":"Best practices for prognostic evaluation of a patient with transthyretin amyloid cardiomyopathy.","volume":"1","author":"Feng","year":"2019","journal-title":"JACC CardioOncol"},{"issue":"22","key":"joi220024r35","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1016\/j.jacc.2019.04.003","article-title":"Transthyretin amyloid cardiomyopathy: JACC state-of-the-art review.","volume":"73","author":"Ruberg","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"joi220024r36","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1001\/jamacardio.2020.6623","article-title":"Association of the V122I transthyretin amyloidosis genetic variant with cardiac structure and function in middle-aged Black adults: Coronary Artery Risk Development in Young Adults (CARDIA) study.","volume":"6","author":"Sinha","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"1","key":"joi220024r37","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1161\/CIR.0000000000000792","article-title":"Cardiac amyloidosis: evolving diagnosis and management: a scientific statement from the American Heart Association.","volume":"142","author":"Kittleson","year":"2020","journal-title":"Circulation"},{"issue":"4","key":"joi220024r38","doi-asserted-by":"publisher","DOI":"10.1161\/HCG.0000000000000084","article-title":"Considerations for cardiovascular genetic and genomic research with marginalized racial and ethnic groups and indigenous peoples: a scientific statement from the American Heart Association.","volume":"14","author":"Mudd-Martin","year":"2021","journal-title":"Circ Genom Precis Med"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2790713\/jama_parcha_2022_oi_220024_1652126472.51925.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T15:02:36Z","timestamp":1652194956000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2790713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":38,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,4,12]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2022.2896","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}