{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:56:33Z","timestamp":1791597393292,"version":"4.3.4"},"reference-count":23,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:sec id=\"ab-jus230001-1\"><jats:title>Importance<\/jats:title><jats:p>Genital herpes is a common sexually transmitted infection caused by 2 related viruses, herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2). Infection is lifelong; currently, there is no cure for HSV infection. Antiviral medications may provide clinical benefits to symptomatic persons. Transmission of HSV from a pregnant person to their infant can occur, most commonly during delivery; when genital lesions or prodromal symptoms are present, cesarean delivery can reduce the risk of transmission. Neonatal herpes infection is uncommon yet can result in substantial morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec id=\"ab-jus230001-2\"><jats:title>Objective<\/jats:title><jats:p>To reaffirm its 2016 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a reaffirmation evidence update on targeted key questions to systematically evaluate the evidence on accuracy, benefits, and harms of routine serologic screening for HSV-2 infection in asymptomatic adolescents, adults, and pregnant persons.<\/jats:p><\/jats:sec><jats:sec id=\"ab-jus230001-3\"><jats:title>Population<\/jats:title><jats:p>Adolescents and adults, including pregnant persons, without known history, signs, or symptoms of genital HSV infection.<\/jats:p><\/jats:sec><jats:sec id=\"ab-jus230001-4\"><jats:title>Evidence Assessment<\/jats:title><jats:p>The USPSTF concludes with moderate certainty that the harms outweigh the benefits for population-based screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons.<\/jats:p><\/jats:sec><jats:sec id=\"ab-jus230001-5\"><jats:title>Recommendation<\/jats:title><jats:p>The USPSTF recommends against routine serologic screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons. 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