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Many of these neural tube defects are caused by low folate levels in the body.<\/jats:p><\/jats:sec>Objective<\/jats:title>The US Preventive Services Task Force (USPSTF) commissioned a reaffirmation evidence update on the benefits and harms of folic acid supplementation.<\/jats:p><\/jats:sec>Population<\/jats:title>Persons who are planning to or could become pregnant.<\/jats:p><\/jats:sec>Evidence Assessment<\/jats:title>The USPSTF concludes that, for persons who are planning to or could become pregnant, there is high certainty that folic acid supplementation has a substantial net benefit to prevent neural tube defects in their offspring.<\/jats:p><\/jats:sec>Recommendation<\/jats:title>The USPSTF recommends that all persons planning to or who could become pregnant take a daily supplement containing 0.4 to 0.8 mg (400 to 800 \u03bcg) of folic acid. (A recommendation)<\/jats:p><\/jats:sec>","DOI":"10.1001\/jama.2023.12876","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T15:01:32Z","timestamp":1690902092000},"page":"454","source":"Crossref","is-referenced-by-count":112,"title":["Folic Acid Supplementation to Prevent Neural Tube Defects"],"prefix":"10.1001","volume":"330","author":[{"name":"US Preventive Services Task Force","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Barry","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda K.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"George Washington University, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Brown University, 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