{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:10:08Z","timestamp":1793880608518,"version":"4.7.0"},"reference-count":27,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"\n Importance<\/jats:title>\n Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non\u2013small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition with chemotherapy remains unknown.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine whether toripalimab in combination with platinum-based chemotherapy will improve event-free survival and major pathological response in patients with stage II or III resectable NSCLC compared with chemotherapy alone.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n \n This randomized clinical trial enrolled patients with stage II or III resectable NSCLC (without\n EGFR<\/jats:italic>\n or\n ALK<\/jats:italic>\n alterations for nonsquamous NSCLC) from March 12, 2020, to June 19, 2023, at 50 participating hospitals in China. The data cutoff date for this interim analysis was November 30, 2022.\n <\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Patients were randomized in a 1:1 ratio to receive 240 mg of toripalimab or placebo once every 3 weeks combined with platinum-based chemotherapy for 3 cycles before surgery and 1 cycle after surgery, followed by toripalimab only (240 mg) or placebo once every 3 weeks for up to 13 cycles.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcomes were event-free survival (assessed by the investigators) and the major pathological response rate (assessed by blinded, independent pathological review). The secondary outcomes included the pathological complete response rate (assessed by blinded, independent pathological review) and adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 501 patients randomized, 404 had stage III NSCLC (202 in the toripalimab\u2009+\u2009chemotherapy group and 202 in the placebo\u2009+\u2009chemotherapy group) and 97 had stage II NSCLC and were excluded from this interim analysis. The median age was 62 years (IQR, 56-65 years), 92% of patients were male, and the median follow-up was 18.3 months (IQR, 12.7-22.5 months). For the primary outcome of event-free survival, the median length was not estimable (95% CI, 24.4 months-not estimable) in the toripalimab group compared with 15.1 months (95% CI, 10.6-21.9 months) in the placebo group (hazard ratio, 0.40 [95% CI, 0.28-0.57],\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). The major pathological response rate (another primary outcome) was 48.5% (95% CI, 41.4%-55.6%) in the toripalimab group compared with 8.4% (95% CI, 5.0%-13.1%) in the placebo group (between-group difference, 40.2% [95% CI, 32.2%-48.1%],\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). The pathological complete response rate (secondary outcome) was 24.8% (95% CI, 19.0%-31.3%) in the toripalimab group compared with 1.0% (95% CI, 0.1%-3.5%) in the placebo group (between-group difference, 23.7% [95% CI, 17.6%-29.8%]). The incidence of immune-related adverse events occurred more frequently in the toripalimab group. No unexpected treatment-related toxic effects were identified. The incidence of grade 3 or higher adverse events, fatal adverse events, and adverse events leading to discontinuation of treatment were comparable between the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n The addition of toripalimab to perioperative chemotherapy led to a significant improvement in event-free survival for patients with resectable stage III NSCLC and this treatment strategy had a manageable safety profile.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT04158440<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2023.24735","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:02:04Z","timestamp":1705402924000},"page":"201","source":"Crossref","is-referenced-by-count":408,"title":["Perioperative Toripalimab Plus Chemotherapy for Patients With Resectable Non\u2013Small Cell Lung Cancer"],"prefix":"10.1001","volume":"331","author":[{"given":"Shun","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Department of Thoracic Surgery, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Pulmonary Hospital, Tong Ji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Neotorch Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Fang","sequence":"additional","affiliation":[{"name":"Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqun","family":"Xing","sequence":"additional","affiliation":[{"name":"Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixun","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital, Shenzhen Institute of Respiratory Diseases, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Mei","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Tan","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Sun","sequence":"additional","affiliation":[{"name":"Cancer Hospital affiliated with Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Xu","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hu","sequence":"additional","affiliation":[{"name":"Tumor Hospital affiliated with Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Yu","sequence":"additional","affiliation":[{"name":"Weifang People\u2019s Hospital, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongliang","family":"Yu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Hospital affiliated with Shantou University Medical College, Shantou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlu","family":"Shan","sequence":"additional","affiliation":[{"name":"Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Xing","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tian","sequence":"additional","affiliation":[{"name":"Qilu Hospital affiliated with Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Chest Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohui","family":"Fang","sequence":"additional","affiliation":[{"name":"Anhui Chest Hospital, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowu","family":"Wu","sequence":"additional","affiliation":[{"name":"Meizhou People\u2019s Hospital (Huangtang Hospital), Meizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"First Hospital of China Medical University, Shenyang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Ye","sequence":"additional","affiliation":[{"name":"Taizhou Hospital of Zhejiang Province, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejie","family":"Cao","sequence":"additional","affiliation":[{"name":"Anhui Provincial Hospital, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Central Hospital affiliated with Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanqing","family":"Li","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Fuzhou Tuberculosis Control Hospital of Fujian, Fuzhou Pulmonary Hospital of Fujian, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keneng","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Cancer Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Cancer Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Henan Provincial Chest Hospital, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Ma","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaican","family":"Cai","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changli","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunshou","family":"Zhu","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Chest Hospital Medical School of Southern University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical College Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hu","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tonghua Central Hospital, Tonghua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guangdong Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Hang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Huang","sequence":"additional","affiliation":[{"name":"Yunnan Cancer Hospital, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiye","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lumin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin Province People\u2019s Hospital, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunxu","family":"Liu","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Lin","sequence":"additional","affiliation":[{"name":"Beijing Cancer Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Junshi Biosciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Junshi Biosciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhen","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai Junshi Biosciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Keegan","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Shanghai Junshi Biosciences, Shanghai, China"},{"name":"TopAlliance Biosciences, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"3","key":"joi230147r1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020.","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"joi230147r2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/S0025-6196(11)60735-0","article-title":"Non\u2013small cell lung cancer.","volume":"83","author":"Molina","year":"2008","journal-title":"Mayo Clin Proc"},{"issue":"21","key":"joi230147r3","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","article-title":"Lung adjuvant cisplatin evaluation.","volume":"26","author":"Pignon","year":"2008","journal-title":"J Clin Oncol"},{"key":"joi230147r4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.lungcan.2016.11.002","article-title":"Impact of age and comorbidity on treatment of non\u2013small cell lung cancer recurrence following complete resection.","volume":"102","author":"Wong","year":"2016","journal-title":"Lung Cancer"},{"issue":"10308","key":"joi230147r5","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/S0140-6736(21)02098-5","article-title":"Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non\u2013small-cell lung cancer (IMpower010).","volume":"398","author":"Felip","year":"2021","journal-title":"Lancet"},{"issue":"10","key":"joi230147r6","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/S1470-2045(22)00518-6","article-title":"Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB\u2013IIIA non\u2013small-cell lung cancer (PEARLS\/KEYNOTE-091).","volume":"23","author":"O\u2019Brien","year":"2022","journal-title":"Lancet Oncol"},{"issue":"21","key":"joi230147r7","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1056\/NEJMoa1810865","article-title":"Pembrolizumab plus chemotherapy for squamous non\u2013small-cell lung cancer.","volume":"379","author":"Paz-Ares","year":"2018","journal-title":"N Engl J Med"},{"issue":"22","key":"joi230147r8","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1056\/NEJMoa1801005","article-title":"Pembrolizumab plus chemotherapy in metastatic non\u2013small-cell lung cancer.","volume":"378","author":"Gandhi","year":"2018","journal-title":"N Engl J Med"},{"issue":"3","key":"joi230147r9","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1200\/JCO.22.00727","article-title":"Toripalimab plus chemotherapy for patients with treatment-naive advanced non\u2013small-cell lung cancer.","volume":"41","author":"Wang","year":"2023","journal-title":"J Clin Oncol"},{"issue":"21","key":"joi230147r10","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1056\/NEJMoa2202170","article-title":"Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer.","volume":"386","author":"Forde","year":"2022","journal-title":"N Engl J Med"},{"issue":"6","key":"joi230147r11","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1056\/NEJMoa2215530","article-title":"Perioperative nivolumab and chemotherapy in stage III non\u2013small-cell lung cancer.","volume":"389","author":"Provencio","year":"2023","journal-title":"N Engl J Med"},{"issue":"6","key":"joi230147r12","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1056\/NEJMoa2302983","article-title":"Perioperative pembrolizumab for early-stage non\u2013small-cell lung cancer.","volume":"389","author":"Wakelee","year":"2023","journal-title":"N Engl J Med"},{"issue":"18","key":"joi230147r13","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1056\/NEJMoa2304875","article-title":"Perioperative durvalumab for resectable non\u2013small-cell lung cancer.","volume":"389","author":"Heymach","year":"2023","journal-title":"N Engl J Med"},{"issue":"1","key":"joi230147r14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13045-018-0693-2","article-title":"Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients.","volume":"12","author":"Tang","year":"2019","journal-title":"J Hematol Oncol"},{"issue":"16","key":"joi230147r15","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1158\/1078-0432.CCR-19-3922","article-title":"Safety, efficacy, and biomarker analysis of toripalimab in previously treated advanced melanoma.","volume":"26","author":"Tang","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"3","key":"joi230147r16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1158\/1078-0432.CCR-21-2210","article-title":"Safety, efficacy, and biomarker analysis of toripalimab in patients with previously treated advanced urothelial carcinoma.","volume":"28","author":"Sheng","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"7","key":"joi230147r17","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1200\/JCO.20.02712","article-title":"Efficacy, safety, and correlative biomarkers of toripalimab in previously treated recurrent or metastatic nasopharyngeal carcinoma.","volume":"39","author":"Wang","year":"2021","journal-title":"J Clin Oncol"},{"issue":"9","key":"joi230147r18","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1038\/s41591-021-01444-0","article-title":"Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma.","volume":"27","author":"Mai","year":"2021","journal-title":"Nat Med"},{"issue":"3","key":"joi230147r19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ccell.2022.02.007","article-title":"Toripalimab plus chemotherapy in treatment-na\u00efve, advanced esophageal squamous cell carcinoma (JUPITER-06).","volume":"40","author":"Wang","year":"2022","journal-title":"Cancer Cell"},{"issue":"20","key":"joi230147r20","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1001\/jama.2023.20181","article-title":"Toripalimab plus chemotherapy for recurrent or metastatic nasopharyngeal carcinoma.","volume":"330","author":"Mai","year":"2023","journal-title":"JAMA"},{"issue":"1","key":"joi230147r21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The eighth edition Lung Cancer Stage Classification.","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest"},{"issue":"5","key":"joi230147r22","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jtho.2020.01.005","article-title":"IASLC multidisciplinary recommendations for pathologic assessment of lung cancer resection specimens after neoadjuvant therapy.","volume":"15","author":"Travis","year":"2020","journal-title":"J Thorac Oncol"},{"issue":"10","key":"joi230147r24","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.13770","article-title":"Safety, antitumor activity, and pharmacokinetics of toripalimab, a programmed cell death 1 inhibitor, in patients with advanced non\u2013small cell lung cancer.","volume":"3","author":"Wang","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"6","key":"joi230147r25","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.102040","article-title":"Neoadjuvant nivolumab plus chemotherapy versus chemotherapy for resectable NSCLC: subpopulation analysis of Chinese patients in CheckMate 816.","volume":"8","author":"Wang","year":"2023","journal-title":"ESMO Open"},{"issue":"5","key":"joi230147r26","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022.","volume":"135","author":"Xia","year":"2022","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"joi230147r27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/JTO.0000000000000033","article-title":"A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non\u2013small-cell lung cancer of adenocarcinoma histology (PIONEER).","volume":"9","author":"Shi","year":"2014","journal-title":"J Thorac Oncol"},{"key":"joi230147r23","unstructured":"US Department of Health and Human Services. Common Terminology Criteria for Adverse Events. Accessed December 19, 2023. https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm#ctc_60"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2813880\/jama_lu_2024_oi_230147_1738962195.9018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T11:02:26Z","timestamp":1739185346000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2813880"}},"subtitle":["The Neotorch Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2023.24735","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}