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Superiority tests were performed at interim analyses and the final analysis if equivalence was not proven. Patients were enrolled between September 2016 and April 2021 at 134 sites in 8 countries, with the last date of follow-up on July 6, 2023. Patients were required to have an indication for a primary prevention ICD, including left ventricular ejection fraction less than or equal to 35%.<\/jats:p><\/jats:sec>Interventions<\/jats:title>Patients were randomized in a 1:1 ratio to receive ATP plus shock vs shock only.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary end point was time to first all-cause shock. Secondary end points included time to first appropriate shock, time to first inappropriate shock, all-cause mortality, and the composite of time to first all-cause shock plus all-cause mortality.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 2595 patients were randomized (mean age, 63.9 years; 22.4% were females). At a mean follow-up of 38 months, first all-cause shock occurred in 129 participants in the ATP plus shock group and 178 participants in the shock only group. The hazard ratio (HR) for the primary end point was 0.72 (95.9% CI, 0.57-0.92), with P<\/jats:italic>\u2009=\u2009.005 for superiority of the ATP plus shock group over the shock only group. During follow-up in an intention-to-treat analysis, the total shock burden per 100 patient-years was not statistically different, at 12.3 and 14.9, respectively (P<\/jats:italic>\u2009=\u2009.70).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The use of a single burst of ATP prior to shock in primary prevention ICD recipients with modern ICD detection programming prolonged the time to first all-cause ICD shock.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT02923726<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jama.2024.16531","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T15:32:07Z","timestamp":1727969527000},"page":"1723","source":"Crossref","is-referenced-by-count":25,"title":["Assessment of Antitachycardia Pacing in Primary Prevention Patients"],"prefix":"10.1001","volume":"332","author":[{"given":"Claudio","family":"Schuger","sequence":"first","affiliation":[{"name":"Clinical 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