{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:05:18Z","timestamp":1792796718260,"version":"4.5.0"},"reference-count":27,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2024,9,24]]},"abstract":"<jats:sec><jats:title>IMPORTANCE<\/jats:title><jats:p>Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used to prevent atrial fibrillation after cardiac surgery (AFACS), but is not evidence-based, carries risks, and is costly.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine whether a lower serum potassium concentration trigger for supplementation is noninferior to a high-normal trigger.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN, SETTING, AND PARTICIPANTS<\/jats:title><jats:p>This open-label, noninferiority, randomized clinical trial was conducted at 23 cardiac surgical centers in the United Kingdom and Germany. Between October 20, 2020, and November 16, 2023, patients with no history of atrial dysrhythmias scheduled for isolated coronary artery bypass grafting (CABG) surgery were enrolled. The last study patient was discharged from the hospital on December 11, 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>INTERVENTIONS<\/jats:title><jats:p>Patients were randomly assigned to a strategy of tight or relaxed potassium control (only supplementing if serum potassium concentration fell below 4.5 mEq\/L or 3.6 mEq\/L, respectively). Patients wore an ambulatory heart rhythm monitor, which was analyzed by a core laboratory masked to treatment assignment.<\/jats:p><\/jats:sec><jats:sec><jats:title>MAIN OUTCOMES AND MEASURES<\/jats:title><jats:p>The prespecified primary end point was clinically detected and electrocardiographically confirmed new-onset AFACS in the first 120 hours after CABG surgery or until hospital discharge, whichever occurred first. All primary outcome events were validated by an event validation committee, which was masked to treatment assignment. Noninferiority of relaxed potassium control was defined as a risk difference for new-onset AFACS with associated upper bound of a 1-sided 97.5% CI of less than 10%. Secondary outcomes included other heart rhythm\u2013related events, clinical outcomes, and cost related to the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 1690 patients (mean age, 65 years; 256 [15%] females) were randomized. The primary end point occurred in 26.2% of patients (n\u2009=\u2009219) in the tight group and 27.8% of patients (n\u2009=\u2009231) in the relaxed group, which is a risk difference of 1.7% (95% CI, \u22122.6% to 5.9%). There was no difference between the groups in the incidence of at least 1 AFACS episode detected by any means or by ambulatory heart rhythm monitor alone, non-AFACS dysrhythmias, in-patient mortality, or length of stay. Per-patient cost for purchasing and administering potassium was significantly lower in the relaxed group (mean difference, $111.89 [95% CI, $103.60-$120.19]; <jats:italic>P<\/jats:italic> &amp;amp;lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS AND RELEVANCE<\/jats:title><jats:p>For AFACS prophylaxis, supplementation only when serum potassium concentration fell below 3.6 mEq\/L was noninferior to the current widespread practice of supplementing potassium to maintain a serum potassium concentration greater than or equal to 4.5 mEq\/L. The lower threshold of supplementation was not associated with any increase in dysrhythmias or adverse clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>TRIAL REGISTRATION<\/jats:title><jats:p>ClinicalTrials.gov Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT04053816\">NCT04053816<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jama.2024.17888","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T16:30:28Z","timestamp":1725121828000},"page":"979","source":"Crossref","is-referenced-by-count":33,"title":["Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery"],"prefix":"10.1001","volume":"332","author":[{"given":"Benjamin","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany"},{"name":"St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, United Kingdom"},{"name":"Outcomes Research Consortium, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall G.","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom"},{"name":"Manchester University NHS Foundation Trust, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Allen","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Jamal","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Sturgess","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sanders","sequence":"additional","affiliation":[{"name":"St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, United Kingdom"},{"name":"King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Opondo","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Roberts","sequence":"additional","affiliation":[{"name":"St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Aron","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Maccaroni","sequence":"additional","affiliation":[{"name":"Basildon University Hospital NHS Trust, Basildon, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gould","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal H.","family":"Kirmani","sequence":"additional","affiliation":[{"name":"Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gibbison","sequence":"additional","affiliation":[{"name":"University of Bristol, Bristol, United Kingdom"},{"name":"University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Kunst","sequence":"additional","affiliation":[{"name":"King\u2019s College London, London, United Kingdom"},{"name":"King\u2019s College Hospital NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zarbock","sequence":"additional","affiliation":[{"name":"University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Kleine-Br\u00fcggeney","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stoppe","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany"},{"name":"University Hospital, W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Pearce","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hughes","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"},{"name":"King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Van Dyck","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Evans","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh E.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Elbourne","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TIGHT K investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Henderson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin","family":"Desai","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keane","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Ruetzler","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Stevenson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Duncker","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie","family":"Magboo","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Barrett","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Jones","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ly-Mee","family":"Yu","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Kiaii","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudie","family":"Lobban","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sanders","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Roberts","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Welch","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christabel","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Hughes","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Baker","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floresca","family":"Garcia","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthos","family":"Sfakianakis","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Baldey","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Chan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Couto","family":"de Sousa","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakam","family":"Abbass","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Campbell","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Kimani","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Szentgyorgyi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Rankin","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios","family":"Athanasakis","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhila","family":"Muthuswamy","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Allanson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lewis","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arron","family":"Finch","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folakemi","family":"Fowe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahja","family":"Paulus","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisma Chellam","family":"Singh","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha","family":"Mathew","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma Dutt","family":"Sunil","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesha","family":"Mathews","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Crasta","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ferguson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schvearn","family":"Allen","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Pokharel","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anie","family":"Nicholas","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Pailing","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Kunst","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Noble","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Saha","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Spooner","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Clarey","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Finney","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Broderick","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Theresa","family":"Depante","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daveena","family":"Meeks","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Pappa","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura-Anne","family":"Dymore-Brown","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Samuels","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tajwinder","family":"Sandhar","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Karami","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Axalan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burt","family":"Vergara","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor \u00a0 \u00a0 \u00a0 \u00a0","family":"Corcoran\u00a0","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Loubani","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ford","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Rowe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Dobbs","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Bulemfu","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Harper","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Sanders","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Lip","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal H","family":"Kirmani","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Baker","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Keogan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abinash","family":"Panda","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kotalczyk","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameenathul Mazaya","family":"Fawzy","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Harikumar","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Clements","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"McQuade","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peris","family":"Widdows","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Winstanley","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherly","family":"Mathew","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Collins","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash P.","family":"Punjabi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ross","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimple","family":"Dixit","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lodge","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Calvelo","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonora","family":"Sefi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricris","family":"Tuason","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Russell","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myril","family":"Mariveles","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Toledano","family":"Lopez","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis G","family":"Kyriazis","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuqing","family":"Liu","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Chacko","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gould","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wilby","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Speight","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan","family":"Ogg","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Watts","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailamma","family":"Mathew","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Salada","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Trott","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Friar","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charon","family":"Brennan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Rawnsley","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Long","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Bose","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Martinovsky","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Sebastian","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanthi","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Aron","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhodri","family":"Handslip","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Farnell-Ward","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Aquino","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Thanasi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Valcher","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Yun","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf","family":"Al-Subaie","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Kabungo","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreeja","family":"Dangol","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Ventura","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Whittaker","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amylene","family":"Luna","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Fernandes","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lloyd","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Maiz","family":"Cordoba","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Kanu","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Juncu","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Sadeque","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Rosser","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Shoeib","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Cheng","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Ford","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Holmes","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Blackwell","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie","family":"Thompson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Waspe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Massey","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hyde","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Martinez","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justina","family":"Strikaite","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Bennett","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Skipper","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Appasamy","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Trivedi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Balmforth","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lewis","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Krasopoulos","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Nixon","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Sawyer","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Joines","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"New","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Hartley","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Webster","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Johnson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Kourliouros","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Sastry","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Walcot","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Proctor","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Srivastaka","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Castro","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Budden","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Park","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"McMillan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Eladawy","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Bradbury","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Somarajan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Jones","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Maccaroni","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Musson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonaifah","family":"Ramirez","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Redman","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faye","family":"Benson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Goodsell","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Eve","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Alexandra","family":"Matias","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanesh","family":"Namjoshi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Abouelela","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Nguyen","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Madziva","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Zibdeh","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Turner","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Jones","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"May","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mills","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Memory","family":"Mwadeyi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Cocks","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Downing","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Mansour","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Newman","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"McCormick","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"England","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Kalita","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francia","family":"Cardinez","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"El-Shafei","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiral","family":"Jhala","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"McDonald","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Jitendra","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Henderson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Abernethy","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"John","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maame","family":"Aduse-Poku","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Colville","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitul Mahesh","family":"Patel","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shaw","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Ali","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Radcliffe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianlucca","family":"Lucchese","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki","family":"Nicou","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelline","family":"Makondo","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Quinn","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Glizevskaja","family":"Glizevskaja","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Anderson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Lavorca","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Smith-Johnson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lushpenko-Brown","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gibbison","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Hopkins","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bonnick","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Irish","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linta","family":"Joseph","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de las Mercedes Rodriguez","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"Lambert","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Rose","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Watkins","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Walach","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunaid","family":"Vohra","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Alston","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Zamvar","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campbell","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa","family":"Geddes","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Tucker","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Callaghan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Stagg","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Downing-James","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Glenwright","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issy","family":"Adamson","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlington","family":"Ray-Alende","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Kleine-Brueggeney","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stoppe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Catena","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Katrin","family":"Matschke","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Rau","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Hellner","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Ott","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valida","family":"Tahirovic","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antria","family":"Karekla","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Knierim","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zarbock","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Meersch-Dini","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Strauss","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahan","family":"Sadjadi","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"von Groote","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Wessels","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Hollenborg","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sch\u00fctzenmeister","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon","family":"Schedding","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Wempe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawwar","family":"Al-Attar","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Hamilton","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Boyd","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lythgoe","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowen","family":"Jones","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Parker","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Brennan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Walsh","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Crossley","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Hamer","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"MacDonald","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Butler","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Flemming","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J","family":"Murphy","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sommer","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Schnabel","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Lamprou","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuran","family":"Zheng","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajavarma","family":"Viswesvaraiah","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Barsamyan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bedford","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Adlan","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Finlay","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Gibbon","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kully","family":"Sandhu","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Giblett","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Barnes","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Juneja","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Cox","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enoch","family":"Akowuah","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Kwok","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josenir","family":"Astarci","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Canter","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Potter","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Vale","sequence":"additional","affiliation":[{"name":"for the TIGHT K investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"joi240106r1","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.atssr.2023.11.019","article-title":"Global cardiac surgical volume and gaps: trends, targets, and way forward.","volume":"2","author":"Vervoort","year":"2024","journal-title":"Ann Thorac Surg Short Rep"},{"issue":"3","key":"joi240106r2","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.21037\/jtd.2018.02.43","article-title":"Fifty years of coronary artery bypass grafting.","volume":"10","author":"Melly","year":"2018","journal-title":"J Thorac Dis"},{"issue":"1","key":"joi240106r3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017966","article-title":"New-onset atrial fibrillation after coronary artery bypass grafting and long-term outcome: a population-based nationwide study from the SWEDEHEART Registry.","volume":"10","author":"Taha","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"14","key":"joi240106r4","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1001\/jama.291.14.1720","article-title":"A multicenter risk index for atrial fibrillation after cardiac surgery.","volume":"291","author":"Mathew","year":"2004","journal-title":"JAMA"},{"issue":"1","key":"joi240106r5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1053\/j.jvca.2018.09.039","article-title":"Society of Cardiovascular Anesthesiologists\/European Association of Cardiothoracic Anaesthetists practice advisory for the management of perioperative atrial fibrillation in patients undergoing cardiac surgery.","volume":"33","author":"O\u2019Brien","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"joi240106r6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jtcvs.2021.03.077","article-title":"Atrial fibrillation after cardiac surgery: a systematic review and meta-analysis.","volume":"165","author":"Caldonazo","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"joi240106r7","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s40140-019-00321-4","article-title":"New-onset atrial fibrillation in adult patients after cardiac surgery.","volume":"9","author":"Burrage","year":"2019","journal-title":"Curr Anesthesiol Rep"},{"issue":"9","key":"joi240106r9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-038001","article-title":"Identifying research priorities in cardiac surgery: a report from the James Lind Alliance Priority Setting Partnership in adult heart surgery.","volume":"10","author":"Lai","year":"2020","journal-title":"BMJ Open"},{"issue":"10","key":"joi240106r10","doi-asserted-by":"publisher","first-page":"33E","DOI":"10.1016\/0002-9149(90)90250-5","article-title":"Potassium and ventricular arrhythmias.","volume":"65","author":"Podrid","year":"1990","journal-title":"Am J Cardiol"},{"issue":"2","key":"joi240106r11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jacc.2003.06.021","article-title":"What is the optimal serum potassium level in cardiovascular patients?","volume":"43","author":"Macdonald","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"joi240106r12","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1177\/17511437211022132","article-title":"Risk factors for new-onset atrial fibrillation during critical illness: a Delphi study.","volume":"23","author":"Bedford","year":"2022","journal-title":"J Intensive Care Soc"},{"issue":"1","key":"joi240106r13","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1186\/s13063-017-2349-x","article-title":"The impact of maintaining serum potassium =3.6 mEq\/L vs =4.5 mEq\/L on the incidence of new-onset atrial fibrillation in the first 120 hours after isolated elective coronary artery bypass grafting: study protocol for a randomised feasibility trial for the proposed Tight K randomized non-inferiority trial.","volume":"18","author":"Campbell","year":"2017","journal-title":"Trials"},{"issue":"16","key":"joi240106r14","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1001\/archinte.160.16.2429","article-title":"New guidelines for potassium replacement in clinical practice: a contemporary review by the National Council on Potassium in Clinical Practice.","volume":"160","author":"Cohn","year":"2000","journal-title":"Arch Intern Med"},{"issue":"3","key":"joi240106r15","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1053\/j.jvca.2021.06.021","article-title":"Maintenance of serum potassium levels = 3.6 mEq\/L vs = 4.5 mEq\/L after isolated elective coronary artery bypass grafting, and the incidence of new-onset atrial fibrillation: pilot and feasibility study results.","volume":"36","author":"Campbell","year":"2022","journal-title":"J Cardiothor Vasc An"},{"issue":"3","key":"joi240106r16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296525","article-title":"Impact of maintaining serum potassium concentration = 3.6mEq\/L versus = 4.5mEq\/L for 120 hours after isolated coronary artery bypass graft surgery on incidence of new onset atrial fibrillation: protocol for a randomized non-inferiority trial.","volume":"19","author":"Campbell","year":"2024","journal-title":"PLoS One"},{"issue":"24","key":"joi240106r17","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1001\/jama.2012.87802","article-title":"Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement.","volume":"308","author":"Piaggio","year":"2012","journal-title":"JAMA"},{"issue":"5","key":"joi240106r18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC.","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"issue":"4","key":"joi240106r19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/MAJ.0b013e3181e73fcf","article-title":"Accuracy of diagnosing atrial flutter and atrial fibrillation from a surface electrocardiogram by hospital physicians: analysis of data from internal medicine departments.","volume":"340","author":"Shiyovich","year":"2010","journal-title":"Am J Med Sci"},{"issue":"1","key":"joi240106r20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jacc.2023.08.017","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines.","volume":"83","author":"Joglar","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"joi240106r21","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1161\/CIRCULATIONAHA.119.040214","article-title":"Noninferiority designed cardiovascular trials in highest-impact journals.","volume":"140","author":"Bikdeli","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"joi240106r22","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-044480","article-title":"Testing for non-inferior mortality: a systematic review of non-inferiority margin sizes and trial characteristics.","volume":"11","author":"Pong","year":"2021","journal-title":"BMJ Open"},{"issue":"1","key":"joi240106r23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1742-7622-10-14","article-title":"Log-binomial models: exploring failed convergence.","volume":"10","author":"Williamson","year":"2013","journal-title":"Emerg Themes Epidemiol"},{"issue":"2","key":"joi240106r24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables.","volume":"34","author":"Cox","year":"2018","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"joi240106r25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5661","article-title":"Consort 2010 statement: extension to cluster randomised trials.","volume":"345","author":"Campbell","year":"2012","journal-title":"BMJ"},{"issue":"3","key":"joi240106r26","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1053\/j.jvca.2021.10.009","article-title":"Inconsistent methodology as a barrier to meaningful research outputs from studies of atrial fibrillation after cardiac surgery.","volume":"36","author":"Campbell","year":"2022","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"4","key":"joi240106r27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/00000658-199710000-00011","article-title":"Atrial fibrillation after cardiac surgery: a major morbid event?","volume":"226","author":"Almassi","year":"1997","journal-title":"Ann Surg"},{"key":"joi240106r8","unstructured":"Atrial fibrillation: diagnosis and management evidence review L: treatment strategies for atrial fibrillation after cardiothoracic surgery. National Institute of Clinical Excellence guideline NG196. Intervention evidence review April 2021. Accessed August 19, 2024. https:\/\/www.nice.org.uk\/guidance\/ng196\/evidence\/l-treatment-strategies-for-atrial-fibrillation-after-cardiothoracic-surgery-pdf-326949243736"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2823246\/jama_obrien_2024_oi_240106_1726513510.93799.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T15:00:58Z","timestamp":1727190058000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2823246"}},"subtitle":["The TIGHT K Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,9,24]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2024.17888","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}