{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:42:49Z","timestamp":1792798969476,"version":"4.5.0"},"reference-count":23,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"\n Importance<\/jats:title>\n Inguinal hernia repair in preterm infants is common and is associated with considerable morbidity. Whether the inguinal hernia should be repaired prior to or after discharge from the neonatal intensive care unit is controversial.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the safety of early vs late surgical repair for preterm infants with an inguinal hernia.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n A multicenter randomized clinical trial including preterm infants with inguinal hernia diagnosed during initial hospitalization was conducted between September 2013 and April 2021 at 39 US hospitals. Follow-up was completed on January 3, 2023.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n In the early repair strategy, infants underwent inguinal hernia repair before neonatal intensive care unit discharge. In the late repair strategy, hernia repair was planned after discharge from the neonatal intensive care unit and when the infants were older than 55 weeks\u2019 postmenstrual age.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was occurrence of any prespecified serious adverse event during the 10-month observation period (determined by a blinded adjudication committee). The secondary outcomes included the total number of days in the hospital during the 10-month observation period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among the 338 randomized infants (172 in the early repair group and 166 in the late repair group), 320 underwent operative repair (86% were male; 2% were Asian, 30% were Black, 16% were Hispanic, 59% were White, and race and ethnicity were unknown in 9% and 4%, respectively; the mean gestational age at birth was 26.6 weeks [SD, 2.8 weeks]; the mean postnatal age at enrollment was 12 weeks [SD, 5 weeks]). Among 308 infants (91%) with complete data (159 in the early repair group and 149 in the late repair group), 44 (28%) in the early repair group vs 27 (18%) in the late repair group had at least 1 serious adverse event (risk difference, \u22127.9% [95% credible interval, \u221216.9% to 0%]; 97% bayesian posterior probability of benefit with late repair). The median number of days in the hospital during the 10-month observation period was 19.0 days (IQR, 9.8 to 35.0 days) in the early repair group vs 16.0 days (IQR, 7.0 to 38.0 days) in the late repair group (82% posterior probability of benefit with late repair). In the prespecified subgroup analyses, the probability that late repair reduced the number of infants with at least 1 serious adverse event was higher in infants with a gestational age younger than 28 weeks and in those with bronchopulmonary dysplasia (99% probability of benefit in each subgroup).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Among preterm infants with inguinal hernia, the late repair strategy resulted in fewer infants having at least 1 serious adverse event. These findings support delaying inguinal hernia repair until after initial discharge from the neonatal intensive care unit.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT01678638<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2024.2302","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T11:28:29Z","timestamp":1711452509000},"page":"1035","source":"Crossref","is-referenced-by-count":40,"title":["Effect of Early vs Late Inguinal Hernia Repair on Serious Adverse Event Rates in Preterm Infants"],"prefix":"10.1001","volume":"331","author":[{"name":"HIP Trial Investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Blakely","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute for Clinical Research and Learning Healthcare and Institute for Implementation Science, University of Texas Health Science Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Krzyzaniak","sequence":"additional","affiliation":[{"name":"Scripps Mercy Hospital, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin S.","family":"Dassinger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pedroza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute for Clinical Research and Learning Healthcare, University of Texas Health Science Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorn-Hendrik","family":"Weitkamp","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankush","family":"Gosain","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Colorado, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cotten","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Hintz","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Rice","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry E.","family":"Courtney","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Lally","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Texas Health Science Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namasivayam","family":"Ambalavanan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Bendel","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Chi T.","family":"Bui","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Kaiser Permanente, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Calkins","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Johns Hopkins All Children\u2019s Hospital, St Petersburg, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Deans","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Nemours Children\u2019s Hospital, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"DeUgarte","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, David Geffen School of Medicine, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gander","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Virginia, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Christian A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Keszler","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kling","sequence":"additional","affiliation":[{"name":"Rady Children\u2019s Hospital and Division of Pediatric Surgery, University of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Hartman","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Islam","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Florida, Gainesville"},{"name":"Department of Surgery, Aga Khan University, Sindh, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Koch","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Medical University of South Carolina, Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Lainwala","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Connecticut Children\u2019s Medical Center, Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Lesher","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Medical University of South Carolina, Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Misra","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, Elliot Hospital, Manchester, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Overbey","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Naval Medical Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Poindexter","sequence":"additional","affiliation":[{"name":"Division of Neonatology, School of Medicine, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Stylianos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Columbia University Medical Center, Morgan Stanley Children\u2019s Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Y.","family":"Tamura","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Valley Children\u2019s Hospital, Madera, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Lucas","sequence":"additional","affiliation":[{"name":"F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"Division of Pediatric Surgery, Naval Medical Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Shaul","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Kaiser Permanente, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"P. Ben","family":"Ham","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University at Buffalo, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Cohen Children\u2019s Medical Center, Northwell Health, New Hyde Park, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Calkins","sequence":"additional","affiliation":[{"name":"Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Garrison","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diomel","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Division of Neonatology, School of Medicine, University of Florida, Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Abdessalam","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Nebraska Medical Center, Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Kvasnovsky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Segura","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, M Health Fairview University of Minnesota Masonic Children\u2019s Hospital, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Shilyansky","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Iowa Stead Family Children\u2019s Hospital, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon E.","family":"Tyson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute for Clinical Research and Learning Healthcare, University of Texas Health Science Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"6","key":"joi240020r1","doi-asserted-by":"publisher","first-page":"e392","DOI":"10.1542\/neo.21-6-e392","article-title":"Inguinal hernia in premature infants.","volume":"21","author":"Ramachandran","year":"2020","journal-title":"Neoreviews"},{"issue":"8","key":"joi240020r2","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/S0022-3468(96)90110-4","article-title":"Hernia survey of the section on surgery of the American Academy of Pediatrics.","volume":"31","author":"Wiener","year":"1996","journal-title":"J Pediatr Surg"},{"issue":"6","key":"joi240020r3","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.jpedsurg.2005.03.018","article-title":"American Academy of Pediatrics section on surgery hernia survey revisited.","volume":"40","author":"Antonoff","year":"2005","journal-title":"J Pediatr Surg"},{"issue":"4","key":"joi240020r4","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1542\/peds.2012-2008","article-title":"Assessment and management of inguinal hernia in infants.","volume":"130","author":"Wang","year":"2012","journal-title":"Pediatrics"},{"issue":"1","key":"joi240020r5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2023-062510","article-title":"Assessment and management of inguinal hernias in children.","volume":"152","author":"Khan","year":"2023","journal-title":"Pediatrics"},{"issue":"2","key":"joi240020r6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.36469\/00001","article-title":"Burden of comorbidities and healthcare resource utilization among Medicaid-enrolled extremely premature infants.","volume":"9","author":"Mowitz","year":"2022","journal-title":"J Health Econ Outcomes Res"},{"issue":"4","key":"joi240020r7","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jpeds.2010.09.047","article-title":"Does timing matter? a national perspective on the risk of incarceration in premature neonates with inguinal hernia.","volume":"158","author":"Lautz","year":"2011","journal-title":"J Pediatr"},{"issue":"6","key":"joi240020r8","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.surg.2020.12.016","article-title":"Complications while awaiting elective inguinal hernia repair in infants: not as common as you thought.","volume":"169","author":"Ferrantella","year":"2021","journal-title":"Surgery"},{"issue":"4","key":"joi240020r9","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.jpedsurg.2017.09.009","article-title":"A multi-institution analysis of predictors of timing of inguinal hernia repair among premature infants.","volume":"53","author":"Gulack","year":"2018","journal-title":"J Pediatr Surg"},{"key":"joi240020r10","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.jss.2022.11.011","article-title":"Optimal timing of inguinal hernia repair in premature infants: a NSQIP-P study.","volume":"283","author":"Sacks","year":"2023","journal-title":"J Surg Res"},{"issue":"1","key":"joi240020r11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jpedsurg.2014.10.035","article-title":"Does timing of neonatal inguinal hernia repair affect outcomes?","volume":"50","author":"Sulkowski","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"4","key":"joi240020r12","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1097\/00000542-199504000-00002","article-title":"Postoperative apnea in former preterm infants after inguinal herniorrhaphy: a combined analysis.","volume":"82","author":"Cot\u00e9","year":"1995","journal-title":"Anesthesiology"},{"issue":"2","key":"joi240020r13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support.","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"1","key":"joi240020r16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/0022-3468(69)90189-4","article-title":"The patent processus vaginalis and the inguinal hernia.","volume":"4","author":"Rowe","year":"1969","journal-title":"J Pediatr Surg"},{"issue":"9","key":"joi240020r17","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s00383-021-04938-7","article-title":"Clinical regression of inguinal hernias in premature infants without surgical repair.","volume":"37","author":"Fleming","year":"2021","journal-title":"Pediatr Surg Int"},{"issue":"8","key":"joi240020r18","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1053\/jpsu.2000.8757","article-title":"Spontaneous regression of clinical inguinal hernias in preterm female infants.","volume":"35","author":"Oudesluys-Murphy","year":"2000","journal-title":"J Pediatr Surg"},{"issue":"4","key":"joi240020r19","doi-asserted-by":"publisher","first-page":"e370","DOI":"10.1097\/SLA.0000000000005099","article-title":"Initial laparotomy versus peritoneal drainage in extremely low birthweight infants with surgical necrotizing enterocolitis or isolated intestinal perforation: a multicenter randomized clinical trial.","volume":"274","author":"Blakely","year":"2021","journal-title":"Ann Surg"},{"issue":"7","key":"joi240020r20","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2022.151640","article-title":"Special considerations in randomized trials investigating neonatal surgical treatments.","volume":"46","author":"Blakely","year":"2022","journal-title":"Semin Perinatol"},{"issue":"1","key":"joi240020r21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1353\/ken.2011.0002","article-title":"Early stopping of clinical trials: charting the ethical terrain.","volume":"21","author":"Malmqvist","year":"2011","journal-title":"Kennedy Inst Ethics J"},{"key":"joi240020r23","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.pedn.2021.06.005","article-title":"Impact of COVID-19 on pediatric clinical research.","volume":"61","author":"Tran","year":"2021","journal-title":"J Pediatr Nurs"},{"key":"joi240020r14","first-page":"129","volume-title":"The ASA Statement on P Values: Context, Process, and Purpose","author":"Wasserstein","year":"2016"},{"key":"joi240020r15","first-page":"1","volume-title":"Moving to a World Beyond \u201cP<0.05\u201d","author":"Wasserstein","year":"2019"},{"key":"joi240020r22","unstructured":"Office for Human Research Protections; Department of Health and Human Services. Guidance on withdrawal of subjects from research: data retention and other related issues. Accessed February 29, 2024. https:\/\/www.hhs.gov\/ohrp\/sites\/default\/files\/ohrp\/policy\/subjectwithdrawal.pdf"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2816629\/jama_blakely_2024_oi_240020_1710443209.74411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T11:28:34Z","timestamp":1711452514000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2816629"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,3,26]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2024.2302","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,26]]}}}