{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:34:34Z","timestamp":1793705674781,"version":"4.5.1"},"reference-count":14,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2025,2,25]]},"abstract":"<jats:sec id=\"ab-joi240150-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Classification of persons with long COVID (LC) or post\u2013COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate newly available data as the field rapidly evolves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-joi240150-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To update the 2023 research index for adults with LC using additional participant data from the Researching COVID to Enhance Recovery (RECOVER-Adult) study and an expanded symptom list based on input from patient communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-joi240150-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>Prospective, observational cohort study including adults 18 years or older with or without known prior SARS-CoV-2 infection who were enrolled at 83 sites in the US and Puerto Rico. Included participants had at least 1 study visit taking place 4.5 months after first SARS-CoV-2 infection or later, and not within 30 days of a reinfection. The study visits took place between October 2021 and March 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-joi240150-7\">\n                    <jats:title>Exposure<\/jats:title>\n                    <jats:p>SARS-CoV-2 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-joi240150-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Presence of LC and participant-reported symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-joi240150-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13\u202f647 participants (11\u202f743 with known SARS-CoV-2 infection and 1904 without known prior SARS-CoV-2 infection; median age, 45 years [IQR, 34-69 years]; and 73% were female) were included. Using the least absolute shrinkage and selection operator analysis regression approach from the 2023 model, symptoms contributing to the updated 2024 index included postexertional malaise, fatigue, brain fog, dizziness, palpitations, change in smell or taste, thirst, chronic cough, chest pain, shortness of breath, and sleep apnea. For the 2024 LC research index, the optimal threshold to identify participants with highly symptomatic LC was a score of 11 or greater. The 2024 index classified 20% of participants with known prior SARS-CoV-2 infection and 4% of those without known prior SARS-CoV-2 infection as having likely LC (vs 21% and 5%, respectively, using the 2023 index) and 39% of participants with known prior SARS-CoV-2 infection as having possible LC, which is a new category for the 2024 model. Cluster analysis identified 5 LC subtypes that tracked quality-of-life measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-joi240150-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>The 2024 LC research index for adults builds on the 2023 index with additional data and symptoms to help researchers classify symptomatic LC and its symptom subtypes. Continued future refinement of the index will be needed as the understanding of LC evolves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jama.2024.24184","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T11:00:28Z","timestamp":1734519628000},"page":"694","source":"Crossref","is-referenced-by-count":91,"title":["2024 Update of the RECOVER-Adult Long COVID Research Index"],"prefix":"10.1001","volume":"333","author":[{"given":"Linda N.","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M.","family":"Erlandson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, 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