{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:06:44Z","timestamp":1793146004195,"version":"4.5.0"},"reference-count":40,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2024,8,13]]},"abstract":"\n Importance<\/jats:title>\n Endometriosis has been associated with an increased risk of ovarian cancer; however, the associations between endometriosis subtypes and ovarian cancer histotypes have not been well-described.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the associations of endometriosis subtypes with incidence of ovarian cancer, both overall and by histotype.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Population-based cohort study using data from the Utah Population Database. The cohort was assembled by matching 78\u202f893 women with endometriosis in a 1:5 ratio to women without endometriosis.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Endometriosis cases were identified via electronic health records and categorized as superficial endometriosis, ovarian endometriomas, deep infiltrating endometriosis, or other.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Estimated adjusted hazard ratios (aHRs), adjusted risk differences (aRDs) per 10\u202f000 women, and 95% CIs for overall ovarian cancer, type I ovarian cancer, and type II ovarian cancer comparing women with each type of endometriosis with women without endometriosis. Models accounted for sociodemographic factors, reproductive history, and past gynecologic operations.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In this Utah-based cohort, the mean (SD) age at first endometriosis diagnosis was 36 (10) years. There were 597 women with ovarian cancer. Ovarian cancer risk was higher among women with endometriosis compared with women without endometriosis (aHR, 4.20 [95% CI, 3.59-4.91]; aRD, 9.90 [95% CI, 7.22-12.57]), and risk of type I ovarian cancer was especially high (aHR, 7.48 [95% CI, 5.80-9.65]; aRD, 7.53 [95% CI, 5.46-9.61]). Ovarian cancer risk was highest in women with deep infiltrating endometriosis and\/or ovarian endometriomas for all ovarian cancers (aHR, 9.66 [95% CI, 7.77-12.00]; aRD, 26.71 [95% CI, 20.01-33.41]), type I ovarian cancer (aHR, 18.96 [95% CI, 13.78-26.08]; aRD, 19.57 [95% CI, 13.80-25.35]), and type II ovarian cancer (aHR, 3.72 [95% CI, 2.31-5.98]; aRD, 2.42 [95% CI, \u22120.01 to 4.85]).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Ovarian cancer risk was markedly increased among women with ovarian endometriomas and\/or deep infiltrating endometriosis. This population may benefit from counseling regarding ovarian cancer risk and prevention and could be an important population for targeted screening and prevention studies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2024.9210","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T11:01:41Z","timestamp":1721214101000},"page":"482","source":"Crossref","is-referenced-by-count":175,"title":["Endometriosis Typology and Ovarian Cancer Risk"],"prefix":"10.1001","volume":"332","author":[{"given":"Mollie E.","family":"Barnard","sequence":"first","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City"},{"name":"Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie V.","family":"Farland","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and Department of Obstetrics and Gynecology, College of Medicine-Tucson, University of Arizona, Tucson"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britton","family":"Trabert","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City"},{"name":"Department of Obstetrics and Gynecology, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Doherty","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong D.","family":"Meeks","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"},{"name":"Department of Pediatrics, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myke","family":"Madsen","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Guinto","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay J.","family":"Collin","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"},{"name":"Department of Obstetrics and Gynecology, University of Utah, Salt Lake City"},{"name":"Gynecologic Oncology, Intermountain Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Page","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynecology, Intermountain Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber C.","family":"Kiser","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Allen-Brady","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Z.","family":"Pollack","sequence":"additional","affiliation":[{"name":"George Mason University, Fairfax, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt R.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Advanced Fertility Care, Scottsdale, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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