{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:54:20Z","timestamp":1791525260169,"version":"4.3.4"},"reference-count":27,"publisher":"American Medical Association (AMA)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"Importance<\/jats:title>Pregnant individuals with polycystic ovary syndrome (PCOS) present with a higher risk of pregnancy complications, including gestational diabetes, preeclampsia, and preterm birth. Myo-inositol supplementation may reduce these risks.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine whether daily supplementation with myo-inositol during pregnancy among individuals with PCOS reduces the risk of a composite outcome of gestational diabetes, preeclampsia, and preterm birth.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This double-blind, placebo-controlled, randomized trial was conducted at 13 hospitals in the Netherlands. Pregnant individuals with PCOS who were between 8 and 16 weeks\u2019 gestation were enrolled between June 2019 and March 2023. Final follow-up was complete on December 27, 2023. Analyses were conducted July 2024.<\/jats:p><\/jats:sec>Interventions<\/jats:title>Participants were randomized on a 1:1 basis to receive sachets with either myo-inositol, 2 g, with 0.2 mg of folic acid twice daily (n\u2009=\u2009230) or matching placebo with 0.2 mg of folic acid only (n\u2009=\u2009234) until delivery.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was a composite of gestational diabetes, preeclampsia, or preterm birth (before 37 weeks\u2019 gestation).<\/jats:p><\/jats:sec>Results<\/jats:title>Among 464 participants, the mean (SD) age was 31.5 (3.8) years; 18 participants (3.9%) reported Asian race and 395 (86.1%) reported White race. The prevalence of biochemical hyperandrogenism was higher at baseline in the myo-inositol group than the placebo group (29.0% [53 of 180] vs 18.5% [37 of 193]). A primary outcome event occurred in 25.0% (n\u2009=\u200956) of participants in the myo-inositol group and 26.8% (n\u2009=\u200961) in the placebo group (relative risk, 0.93 [95% CI, 0.68-1.28]; P<\/jats:italic>\u2009=\u2009.67).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>Myo-inositol supplementation during pregnancy did not reduce the incidence of a composite of gestational diabetes, preeclampsia, or preterm birth in patients with PCOS.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>onderzoekmetmensen.nl Identifier: NL67329.078.18<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jama.2025.13668","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:00:47Z","timestamp":1757343647000},"page":"1151","source":"Crossref","is-referenced-by-count":13,"title":["Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome"],"prefix":"10.1001","volume":"334","author":[{"given":"Anne W. 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