{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:31:15Z","timestamp":1794407475383,"version":"4.9.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"\n Importance<\/jats:title>\n Multiparametric magnetic resonance imaging (MRI), with or without prostate biopsy, has become the standard of care for diagnosing clinically significant prostate cancer. Resource capacity limits widespread adoption. Biparametric MRI, which omits the gadolinium contrast sequence, is a shorter and cheaper alternative offering time-saving capacity gains for health systems globally.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess whether biparametric MRI is noninferior to multiparametric MRI for diagnosis of clinically significant prostate cancer.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n A prospective, multicenter, within-patient, noninferiority trial of biopsy-naive men from 22 centers (12 countries) with clinical suspicion of prostate cancer (elevated prostate-specific antigen [PSA] level and\/or abnormal digital rectal examination findings) from April 2022 to September 2023, with the last follow-up conducted on December 3, 2024.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Participants underwent multiparametric MRI, comprising T2-weighted, diffusion-weighted, and dynamic contrast\u2013enhanced (DCE) sequences. Radiologists reported abbreviated biparametric MRI first (T2-weighted and diffusion-weighted), blinded to the DCE sequence. After unblinding, radiologists reported the full multiparametric MRI. Patients underwent a targeted biopsy with or without systematic biopsy if either biparametric MRI or multiparametric MRI was suggestive of clinically significant prostate cancer.<\/jats:p>\n <\/jats:sec>\n \n Main outcomes and measures<\/jats:title>\n The primary outcome was the proportion of men with clinically significant prostate cancer. Secondary outcomes included the proportion of men with clinically insignificant cancer. The noninferiority margin was 5%.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 555 men recruited, 490 were included for primary outcome analysis. Median age was 65 (IQR, 59-70) years and median PSA level was 5.6 (IQR, 4.4-8.0) ng\/mL. The proportion of patients with abnormal digital rectal examination findings was 12.7%. Biparametric MRI was noninferior to multiparametric MRI, detecting clinically significant prostate cancer in 143 of 490 men (29.2%), compared with 145 of 490 men (29.6%) (difference, \u22120.4 [95% CI, \u22121.2 to 0.4] percentage points;\n P<\/jats:italic>\n \u2009=\u2009.50). Biparametric MRI detected clinically insignificant cancer in 45 of 490 men (9.2%), compared with 47 of 490 men (9.6%) with the use of multiparametric MRI (difference, \u22120.4 [95% CI, \u22121.2 to 0.4] percentage points). Central quality control demonstrated that 99% of scans were of adequate diagnostic quality.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion and relevance<\/jats:title>\n In men with suspected prostate cancer, provided image quality is adequate, an abbreviated biparametric MRI scan, with or without targeted biopsy, could become the new standard of care for prostate cancer diagnosis. With approximately 4 million prostate MRIs performed globally annually, adopting biparametric MRI could substantially increase scanner throughput and reduce costs worldwide.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT04571840<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2025.13722","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T15:00:21Z","timestamp":1757516421000},"page":"1170","source":"Crossref","is-referenced-by-count":92,"title":["Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis"],"prefix":"10.1001","volume":"334","author":[{"given":"Alexander B.C.D.","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqua","family":"Asif","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridhi","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Applied Health Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Panebianco","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossano","family":"Girometti","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Medicine, University of Udine, Udine, Italy"},{"name":"Institute of Radiology, University Hospital S. Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeet","family":"Ghai","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto, Ontario, Canada"},{"name":"University Health Network\u2013Mount Sinai Hospital\u2013Women\u2019s College Hospital, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Urology Department Reina Sofia University Hospital, IMIBIC, Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bud\u00e4us","sequence":"additional","affiliation":[{"name":"Martini-Klinik Prostate Cancer Center, University Hospital-Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Martini-Klinik Prostate Cancer Center and Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Philipp","family":"Radtke","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital D\u00fcsseldorf, Medical Faculty, Heinrich-Heine University D\u00fcsseldorf, Germany"},{"name":"Department of Radiology, German Cancer Research Center, Heidelburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kesch","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Essen, Essen, Germany"},{"name":"German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Cobelli","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tho","family":"Pham","sequence":"additional","affiliation":[{"name":"Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir S.","family":"Taneja","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim C.","family":"Hu","sequence":"additional","affiliation":[{"name":"Brady Department of Urology, New York Presbyterian Weill Cornell Medicine Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ash","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1.","family":"Rodr\u00edguez Cabello","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario Sanitas La Moraleja, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano B.","family":"Dias","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto, Ontario, Canada"},{"name":"University Health Network\u2013Mount Sinai Hospital\u2013Women\u2019s College Hospital, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Radiology, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Mynderse","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Borghi","sequence":"additional","affiliation":[{"name":"Centro de Urolog\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Boesen","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Research, Herlev Gentofte University Hospital, Hellerup, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paras","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Royal Free London NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00eble","family":"Renard-Penna","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"Department of Radiology, H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Leow","sequence":"additional","affiliation":[{"name":"Department of Urology, Tan Tock Seng Hospital, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Falkenbach","sequence":"additional","affiliation":[{"name":"Martini-Klinik Prostate Cancer Center, University Hospital-Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Martini-Klinik Prostate Cancer Center and Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pecoraro","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Giannarini","sequence":"additional","affiliation":[{"name":"Urology Unit, University Hospital S. Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Perlis","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgical Oncology, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"L\u00f3pez-Ruiz","sequence":"additional","affiliation":[{"name":"Radiology Department Reina Sofia University Hospital, IMIBIC, Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Kastner","sequence":"additional","affiliation":[{"name":"Department of Urology, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Schimm\u00f6ller","sequence":"additional","affiliation":[{"name":"University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, Germany"},{"name":"Department of Diagnostic, Interventional Radiology and Nuclear Medicine, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marimo","family":"Rossiter","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramit","family":"Khetrapal","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinson Wai-Shun","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline S.","family":"Clarke","sequence":"additional","affiliation":[{"name":"UCL Research Department of Primary Care and Population Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonit","family":"Punwani","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Brew-Graves","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, UCLH NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Brembilla","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J. A.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemisi","family":"Takwoingi","sequence":"additional","affiliation":[{"name":"Department of Applied Health Sciences, University of Birmingham, Birmingham, United Kingdom"},{"name":"NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Emberton","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Giganti","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Department of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeru","family":"Kasivisvanathan","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, UCL, London, United Kingdom"},{"name":"Department of Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PRIME Study Group Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Crestani","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sciarra","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Evangelista","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Freeman","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kirkham","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Zlotta","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Grey","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Blanca","family":"Pedregosa","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bjartell","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ryan","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tong","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Warren","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Borrelli","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonette","family":"Andrews","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Finelli","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ciardi","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Rannikko","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Stabile","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnauld","family":"Villers","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Platas Sancho","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Baring","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashoke","family":"Roy","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balqiisa","family":"Issa","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Isra\u00ebl","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris A","family":"Hadaschik","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Aull\u00f3 Gonzalez","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L","family":"English","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Zuiani","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christien","family":"Caris","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Von Stempel","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Amate","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel ZP","family":"Yong","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Rozze","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J","family":"Lomas","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Cannoletta","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Wang Chang","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Messina","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Chun","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Zussino","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Antoch","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gandaglia","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Robert","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Sauter","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Thevarajah","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Sorrell","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel","family":"McBain","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Reis","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando","family":"Rios Pita","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Potyka","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iztok","family":"Caglic","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanlou","family":"Collavino","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Theysohn","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincy","family":"Koshy","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Yi (Jessica)","family":"Weng","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Withington","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"van Egmond","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Piper","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Deeks","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"O'Brien","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Valero","family":"Rosa","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Sanz Miguela\u00f1ez","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Mesa","family":"Quesada","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jannusch","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateri","family":"Corr","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Kenneth","family":"Haines","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lale","family":"Umutlu","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Quarta","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Casarotto","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Gimeno","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Orecchia","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Moretti","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Laschena","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Drewes","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"de Rooij","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Sanchez","family":"Ostos","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bicchetti","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gatti","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de los Desamparados\u00a0","family":"Esteban Peris\u00a0","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Volpacchio","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Prentice","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Graefen","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Soligo","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Boschheidgen","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias C","family":"Roethke","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Monte","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mausam","family":"Singhera","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Wenzel","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monali","family":"Fatterpekar","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulham","family":"Al-Nader","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykyta","family":"Kachanov","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Shaida","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Fleshner","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Muirhead","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Vasdev","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimalan","family":"Sanmugalingam","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nis","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Vicente","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Albers","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Incze","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Ryan","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rouvier","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Mead","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Charles","family":"Mozer","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"De Visschere","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Publio Cesar Cavalcante","family":"Viana","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael E","family":"Jimenez","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"Novotta","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Huang","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Karlin Jepsen","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Frese","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Clow","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouvier","family":"Al-Monajjed","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lewis","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Cashman","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pizzolitto","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lelie","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Lindner","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Shah","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Al-Hammouri","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Gonz\u00e1lez","family":"Sanchez","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharakeswara","family":"Bathala","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodorus H","family":"van der Kwast","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reid","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"McClure","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Maurer","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Peruzzi","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"L\u00f8gager","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Prabhu","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Wagaskar","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Phin","family":"Tan","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Carlos","family":"Nahas","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Witjes","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew Lam","family":"Chong","sequence":"additional","affiliation":[{"name":"for the PRIME Study Group Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"joi250059r1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/bju.14809","article-title":"NICE guidance\u2014prostate cancer: diagnosis and management.","volume":"124","author":"National Institute for Health and Care Excellence","year":"2019","journal-title":"BJU Int"},{"issue":"2","key":"joi250059r2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.eururo.2020.09.042","article-title":"EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer\u20142020 Update, part 1: screening, diagnosis, and local treatment with curative intent.","volume":"79","author":"Mottet","year":"2021","journal-title":"Eur Urol"},{"issue":"1","key":"joi250059r3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/JU.0000000000002757","article-title":"Clinically localized prostate cancer: AUA\/ASTRO Guideline, part I: introduction, risk assessment, staging, and risk-based management.","volume":"208","author":"Eastham","year":"2022","journal-title":"J Urol"},{"issue":"10437","key":"joi250059r4","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/S0140-6736(24)00651-2","article-title":"The Lancet Commission on prostate cancer: planning for the surge in cases.","volume":"403","author":"James","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"joi250059r5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/s41391-024-00896-y","article-title":"Trends in pre-biopsy MRI usage for prostate cancer detection, 2007-2022.","volume":"1-4","author":"Soerensen","year":"2022","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"2","key":"joi250059r6","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.0219","article-title":"Assessment of the diagnostic accuracy of biparametric magnetic resonance imaging for prostate cancer in biopsy-naive men: the Biparametric MRI for Detection of Prostate Cancer (BIDOC) study.","volume":"1","author":"Boesen","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"2","key":"joi250059r7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2214\/AJR.18.20103","article-title":"Abbreviated biparametric versus standard multiparametric mri for diagnosis of prostate cancer: a systematic review and meta-analysis.","volume":"212","author":"Kang","year":"2019","journal-title":"AJR Am J Roentgenol"},{"issue":"20","key":"joi250059r8","doi-asserted-by":"publisher","first-page":"vii","DOI":"10.3310\/hta17200","article-title":"The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy: a systematic review and economic evaluation.","volume":"17","author":"Mowatt","year":"2013","journal-title":"Health Technol Assess"},{"issue":"5","key":"joi250059r9","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.eururo.2019.05.029","article-title":"High diagnostic performance of short magnetic resonance imaging protocols for prostate cancer detection in biopsy-na\u00efve men: the next step in magnetic resonance imaging accessibility.","volume":"76","author":"van der Leest","year":"2019","journal-title":"Eur Urol"},{"issue":"2","key":"joi250059r10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/jmri.25625","article-title":"Gadolinium-based contrast agents: a comprehensive risk assessment.","volume":"46","author":"Fraum","year":"2017","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"joi250059r12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/bju.14759","article-title":"Biparametric vs multiparametric prostate magnetic resonance imaging for the detection of prostate cancer in treatment-na\u00efve patients: a diagnostic test accuracy systematic review and meta-analysis.","volume":"124","author":"Alabousi","year":"2019","journal-title":"BJU Int"},{"issue":"1","key":"joi250059r13","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.231130","article-title":"Global variation in magnetic resonance imaging quality of the prostate.","volume":"309","author":"Giganti","year":"2023","journal-title":"Radiology"},{"issue":"3","key":"joi250059r14","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.eururo.2019.02.033","article-title":"Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2.","volume":"76","author":"Turkbey","year":"2019","journal-title":"Eur Urol"},{"issue":"1","key":"joi250059r15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.eururo.2022.02.021","article-title":"Is it PRIME time for biparametric magnetic resonance imaging in prostate cancer diagnosis?","volume":"82","author":"Ng","year":"2022","journal-title":"Eur Urol"},{"issue":"6","key":"joi250059r16","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.euo.2021.03.007","article-title":"Diagnostic accuracy of single-plane biparametric and multiparametric magnetic resonance imaging in prostate cancer: a randomized noninferiority trial in biopsy-na\u00efve men.","volume":"4","author":"Russo","year":"2021","journal-title":"Eur Urol Oncol"},{"issue":"4","key":"joi250059r17","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1007\/s00330-011-2377-y","article-title":"ESUR prostate MR guidelines 2012.","volume":"22","author":"Barentsz","year":"2012","journal-title":"Eur Radiol"},{"issue":"12","key":"joi250059r18","doi-asserted-by":"publisher","first-page":"416","DOI":"10.4329\/wjr.v9.i12.416","article-title":"Dynamic contrast-enhanced magnetic resonance imaging of prostate cancer: a review of current methods and applications.","volume":"9","author":"Mazaheri","year":"2017","journal-title":"World J Radiol"},{"issue":"4","key":"joi250059r19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070280","article-title":"Comparing biparametric to multiparametric MRI in the diagnosis of clinically significant prostate cancer in biopsy-naive men (PRIME): a prospective, international, multicentre, non-inferiority within-patient, diagnostic yield trial protocol.","volume":"13","author":"Asif","year":"2023","journal-title":"BMJ Open"},{"issue":"4","key":"joi250059r20","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.eururo.2010.12.009","article-title":"Magnetic resonance imaging for the detection, localisation, and characterisation of prostate cancer: recommendations from a European consensus meeting.","volume":"59","author":"Dickinson","year":"2011","journal-title":"Eur Urol"},{"issue":"4","key":"joi250059r21","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.eururo.2013.03.030","article-title":"Standards of reporting for MRI-targeted biopsy studies (START) of the prostate: recommendations from an International Working Group.","volume":"64","author":"Moore","year":"2013","journal-title":"Eur Urol"},{"issue":"19","key":"joi250059r22","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-targeted or standard biopsy for prostate-cancer diagnosis.","volume":"378","author":"Kasivisvanathan","year":"2018","journal-title":"N Engl J Med"},{"key":"joi250059r23","doi-asserted-by":"publisher","first-page":"h5527","DOI":"10.1136\/bmj.h5527","article-title":"STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies.","volume":"351","author":"Bossuyt","year":"2015","journal-title":"BMJ"},{"issue":"6","key":"joi250059r24","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction.","volume":"11","author":"Rosen","year":"1999","journal-title":"Int J Impot Res"},{"issue":"5","key":"joi250059r26","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.euo.2020.06.007","article-title":"Prostate Imaging Quality (PI-QUAL): a new quality control scoring system for multiparametric magnetic resonance imaging of the prostate from the PRECISION trial.","volume":"3","author":"Giganti","year":"2020","journal-title":"Eur Urol Oncol"},{"issue":"1","key":"joi250059r27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41391-019-0158-x","article-title":"Financial implications of biparametric prostate MRI.","volume":"23","author":"Porter","year":"2020","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"1","key":"joi250059r28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.eururo.2018.09.033","article-title":"A dedicated prostate MRI teaching course improves the ability of the urologist to interpret clinically significant prostate cancer on multiparametric MRI.","volume":"75","author":"Kasivisvanathan","year":"2019","journal-title":"Eur Urol"},{"issue":"10","key":"joi250059r29","doi-asserted-by":"publisher","first-page":"5404","DOI":"10.1007\/s00330-020-06929-z","article-title":"ESUR\/ESUI consensus statements on multi-parametric MRI for the detection of clinically significant prostate cancer: quality requirements for image acquisition, interpretation and radiologists\u2019 training.","volume":"30","author":"de Rooij","year":"2020","journal-title":"Eur Radiol"},{"issue":"9","key":"joi250059r30","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.jacr.2024.04.008","article-title":"Improving prostate MR image quality in practice\u2014initial results from the ACR Prostate MR Image Quality Improvement Collaborative.","volume":"21","author":"Purysko","year":"2024","journal-title":"J Am Coll Radiol"},{"issue":"11","key":"joi250059r31","doi-asserted-by":"publisher","first-page":"7068","DOI":"10.1007\/s00330-024-10795-4","article-title":"PI-QUAL version 2: an update of a standardised scoring system for the assessment of image quality of prostate MRI.","volume":"34","author":"de Rooij","year":"2024","journal-title":"Eur Radiol"},{"key":"joi250059r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109804","article-title":"Comparison of biparametric versus multiparametric prostate MRI for the detection of extracapsular extension and seminal vesicle invasion in biopsy na\u00efve patients.","volume":"141","author":"Caglic","year":"2021","journal-title":"Eur J Radiol"},{"issue":"7","key":"joi250059r33","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/S1470-2045(24)00220-1","article-title":"Artificial intelligence and radiologists in prostate cancer detection on MRI (PI-CAI): an international, paired, non-inferiority, confirmatory study.","volume":"25","author":"Saha","year":"2024","journal-title":"Lancet Oncol"},{"issue":"1","key":"joi250059r35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.eururo.2025.04.018","article-title":"Artificial intelligence in prostate cancer diagnosis on magnetic resonance imaging: time for a new PARADIGM.","volume":"88","author":"Ng","year":"2025","journal-title":"Eur Urol"},{"key":"joi250059r11","unstructured":"European Society of Urogenital Radiology. ESUR Guidelines on Contrast Agents 10.0. Published 2018. Accessed January 24, 2025. https:\/\/www.esur.org\/wp-content\/uploads\/2022\/03\/ESUR-Guidelines-10_0-Final-Version.pdf"},{"key":"joi250059r25","unstructured":"ePROVIDE\u2014Mapi Research Trust. International Prostate Symptom Score (I-PSS). Published August 22, 2024. Accessed April 17, 2021. https:\/\/eprovide.mapi-trust.org\/instruments\/international-prostate-symptom-score"},{"key":"joi250059r34","unstructured":"Royal College of Radiologists. Workforce Census 2022. Accessed February 29, 2024. https:\/\/www.rcr.ac.uk\/news-policy\/policy-reports-initiatives\/clinical-radiology-census-reports\/"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2838799\/jama_ng_2025_oi_250059_1769613613.66821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:00:46Z","timestamp":1769616046000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2838799"}},"subtitle":["The PRIME Diagnostic Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2025,10,7]]},"references-count":35,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,10,7]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2025.13722","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,7]]}}}