{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:06:24Z","timestamp":1789851984515,"version":"4.0.1"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"\n Importance<\/jats:title>\n The efficacy and safety of guideline-recommended treatments for heart failure (HF) are uncertain in patients with Chagas disease.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of the angiotensin receptor-neprilysin inhibitor sacubitril\/valsartan in patients with HF with reduced ejection fraction due to Chagas disease.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n From December 10, 2019, through September 13, 2023, patients with HF, confirmed diagnosis of Chagas disease, left ventricular ejection fraction of 40% or less, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) of 600 pg\/mL or greater (or B-type natriuretic peptide [BNP] \u2265150 pg\/mL) or 400 pg\/mL or greater (or BNP \u2265100 pg\/mL) if hospitalized for HF within the previous 12 months were screened at 83 sites in Argentina, Brazil, Colombia, and Mexico. Statistical analysis was conducted between May and July 2025.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Patients were randomized to receive sacubitril\/valsartan (target dose, 200 mg twice daily) or enalapril (target dose, 10 mg twice daily), in addition to standard therapy.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary end point was a hierarchical composite outcome tested, in order, of death from cardiovascular causes, hospitalization for HF, or relative change in NT-proBNP from baseline to 12 weeks. The primary analysis was done using a win ratio approach.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, 462 participants were randomized to receive sacubitril\/valsartan and 460 to receive enalapril (mean [SD] age, 64.2 [10.8] years; 387 [42.0%] were female). Over a median (IQR) follow-up of 25.2 (18.4-33.2) months, cardiovascular death occurred in 110 patients (23.8% [18.3% wins in the hierarchical comparison]) in the sacubitril\/valsartan group and 117 patients (25.4% [17.5% wins]) in the enalapril group. A total of 102 patients (22.1% [7.7% wins]) in the sacubitril\/valsartan group and 111 (24.1% [6.9% wins]) in the enalapril group experienced a first hospitalization for HF. Patients in the sacubitril\/valsartan group had a median (IQR) decrease in NT-proBNP of 30.6% (\u221254.3% to \u22120.9%) at 12 weeks, leading to 22.5% wins, while those in the enalapril group had a 5.5% (\u221231.9% to 37.5%) decrease (7.2% wins). The resulting stratified win ratio was 1.52 (95% CI, 1.28-1.82;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001) for sacubitril\/valsartan compared with enalapril.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In patients with HF with reduced ejection fraction due to Chagas disease, there was no significant difference in clinical outcomes between sacubitril\/valsartan and enalapril, but there was a greater reduction in NT-proBNP at 12 weeks in patients in the sacubitril\/valsartan group.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT04023227<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2025.19808","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T16:00:20Z","timestamp":1764777620000},"page":"49","source":"Crossref","is-referenced-by-count":10,"title":["Sacubitril\/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease"],"prefix":"10.1001","volume":"335","author":[{"given":"Renato D.","family":"Lopes","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute (DCRI), Duke Health, Durham, North Carolina"},{"name":"Brazilian Clinical Research Institute (BCRI), S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edimar Alcides","family":"Bocchi","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo","family":"Echeverr\u00eda","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular de Colombia, Floridablanca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Demacq","sequence":"additional","affiliation":[{"name":"Novartis Biociencias SA, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Gabriel Melo","family":"de Barros e Silva","sequence":"additional","affiliation":[{"name":"Brazilian Clinical Research Institute (BCRI), S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Mazza","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Brazilian Clinical Research Institute (BCRI), S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Damiani","sequence":"additional","affiliation":[{"name":"Brazilian Clinical Research Institute (BCRI), S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarfaraz","family":"Sayyed","sequence":"additional","affiliation":[{"name":"Novartis Healthcare Pvt Ltd, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liandra A. F.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Brazilian Clinical Research Institute (BCRI), S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo Holanda M.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Brazilian Clinical Research Institute (BCRI), S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Kevorkian","sequence":"additional","affiliation":[{"name":"Hospital D.F. Santojanni, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Ramires","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cecilia","family":"Bahit","sequence":"additional","affiliation":[{"name":"INECO Neurociencias Oro\u00f1o, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Hospital de Cardiologia, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Ch\u00e1vez-Mendoza","sequence":"additional","affiliation":[{"name":"Hospital de Cardiologia, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adegil Henrique","family":"Miguel da Silva","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia e Transplantes do DF, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aguinaldo","family":"Coelho da Silva","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas da Universidade Federal de Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Aguinaldo F.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade Federal de Goias, Goi\u00e2nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Alejandro","family":"Romano","sequence":"additional","affiliation":[{"name":"Instituto de Diagnostico e Investigaciones Medicas (IDIM), Formosa, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Parneix","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Segura","sequence":"additional","affiliation":[{"name":"Oaxaca Site Management Organization SC, Oaxaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Cassio Broilo","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Evang\u00e9lica Beneficente de Minas Gerais, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Edgardo","family":"Botta","sequence":"additional","affiliation":[{"name":"Hospital Provincial Dr. Jos\u00e9 Maria Cullen, Santa F\u00e9, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edileide","family":"de Barros","sequence":"additional","affiliation":[{"name":"Instituto Dante Pazzanese de Cardiologia, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Roque","family":"Perna","sequence":"additional","affiliation":[{"name":"Instituto de Cardiolog\u00eda de Corrientes \u201cJuana Francisca Cabral,\u201d Corrientes, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Clinica Fusavim Privada SRL, Cordoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin Roberto","family":"Quiroz Diaz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n de Investigaciones M\u00e9dicas San Gil-IPS, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilson Soares","family":"Feitosa-Filho","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia da Bahia, Hospital Santa Izabel, Salvador, Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela Viviana","family":"Severini","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Santa Luc\u00eda, Formosa, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Molina","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil"},{"name":"Department of Infectious Diseases, Vall d'Hebron University Hospital, PROSICS, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline dos Santos Sampaio","family":"Miranda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cardiologia (INC), Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgelina","family":"Sala","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Clinicas Rosario, Santa F\u00e9, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Kerr Saraiva","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Cl\u00ednica de Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo","family":"Carbajales","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Cardiologia, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia Nigro","family":"Maia","sequence":"additional","affiliation":[{"name":"Centro Integrado de Pesquisa (CIP), Hospital de Base Rio Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Santana Passos","sequence":"additional","affiliation":[{"name":"Hospital Ana Nery, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vinicius","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Faculdade de Medicina de Ribeir\u00e3o Preto USP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Consola\u00e7\u00e3o V.","family":"Moreira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Ci\u00eancias da Sa\u00fade - Unidade de Pesquisa - Hospital Fel\u00edcio Rocho, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmo P.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Cl\u00ednicas do HC\/UFMG, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Esteves","family":"Hernandes","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Votuporanga, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Hominal","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Clinicas del Litoral SRL, Santa F\u00e9, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Saa","family":"Zarandon","sequence":"additional","affiliation":[{"name":"Hospital Central, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Leon de la Fuente","sequence":"additional","affiliation":[{"name":"Centro Cardiovascular Salta, Salta, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roque","family":"Aras","sequence":"additional","affiliation":[{"name":"N\u00facleo de Ensaios Cl\u00ednicos da Bahia\/HUPES\/UFBA, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silm\u00e9ia Garcia Zanati","family":"Bazan","sequence":"additional","affiliation":[{"name":"Unidade de Pesquisa Cl\u00ednica da Faculdade de Medicina de Botucatu, Unesp, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Tel\u00eamaco","family":"Luiz da Silva","sequence":"additional","affiliation":[{"name":"Eurolatino Pesquisas M\u00e9dicas Ltda, Uberl\u00e2ndia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagner","family":"Madrini","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Wilson Alves","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Pronto Socorro Cardiol\u00f3gico Universit\u00e1rio de Pernambuco Prof. Luiz Tavares, PROCAPE\/UPE Setor, Ambulat\u00f3rio de Doen\u00e7a de Chagas e Insufici\u00eancia Card\u00edaca, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wladmir Faustino","family":"Saporito","sequence":"additional","affiliation":[{"name":"Instituto de Mol\u00e9stias Cardiovasculares de Tatu\u00ed, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Gimpelewicz","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J. V.","family":"McMurray","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia","family":"Figueira Avezum Oliveira","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimar","family":"Kunz Sebba Barroso de Souza","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Vellosa Schwartzmann","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto","family":"Menezes Lorga Filho","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilma","family":"Souza","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gomes Taques Fonseca","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Ascen\u00e7\u00e3o de Souza","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Mourilhe Rocha","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murillo","family":"de Oliveira Antunes","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"de Souza Brito","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"da Silva Fragata","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Oliveira","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estevao","family":"Lanna Figueiredo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Eduardo","family":"Abib","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Barreto Silva","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Batista de Lima","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pereira Silva","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Creuza","family":"Macedo Goes Rocha","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Demaman Andres","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aloisio","family":"Rocha","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Freitas Fernandes","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezar","family":"Mesas","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"Noya Rabelo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Albuquerque","family":"de Figueiredo Neto","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmar","family":"Reis","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donaldy Gustavo","family":"da Silva Sampaio","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Antonio Muntaner","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Romano Monta\u00f1a","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Andres","family":"Pereyra Sueldo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia Luz","family":"Lobo Marquez","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Visser","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Felipe Martinez","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Armando Luquez","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Adolfo Paterlini","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Guzman","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias Nicolas","family":"Lugo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jazm\u00edn","family":"Fernandez Moutin","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Bornancini","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Garc\u00eda Brasca","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel John","family":"de Francisco Li\u00e9vano Triana","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Diego","family":"Higuera Cobos","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo Orlando","family":"Trout Guardiola","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Olaya S\u00e1nchez","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique Alexander","family":"Berr\u00edos B\u00e1rcenas","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Francisco","family":"Mendez Machado","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Peralta Rosado","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Kajita","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia","family":"Nasi Laranjeira","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Montalv\u00e3o","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"Ianof","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Akimi Suiama","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Zanata","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"de Mattos Egydio","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Felix","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Solizetto","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamanda","family":"Silva","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helo\u00edsa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Simonelli Danesi","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Akemi Yamada","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia","family":"Palmeria Pinto","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Rizzato","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lisboa","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Rodrigues Lopes","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Engelmann Arantes","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Zeigler Ananias","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Maria","family":"da Silva Abib","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamy Alicia","family":"Freire Maciel","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Seixas","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Bronhara","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Andrade de Freitas","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Luccas","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Mendez Braz","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Feres Maron","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Rodrigues Coradetti","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Pereira Luca","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"de Carvalho Maffei","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Franceschi da Silva","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Prates Riva","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia","family":"Silva Farche","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sh\u00e9rrira","family":"Menezes Garavelo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Tarracata Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Risson Belinkovski","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Giusti Rossi","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"de Sousa Mesquita","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Clementino de Oliveira","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Aleixo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauane","family":"Belo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Morata","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alef","family":"Nunes","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Colaiacovo","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrews","family":"Emerenciano","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Correa Travassos","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Camargo dos Santos","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Furlan","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Souza","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathlen","family":"Melo Contardi","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phaola","family":"Almeida","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Alves Mariani de Oliveira","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Sayuri Goya Higa","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia Beatriz","family":"Oliveira Dam\u00e1sio","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Maria","family":"de Melo Silva","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Granger","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Martinez","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Pieper","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Toledo","family":"Campo Dall'Orto","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germano Em\u00edlio","family":"Concei\u00e7\u00e3o Souza","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Egydio","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Danesi","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriadne","family":"Bertolin","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristoteles","family":"Alencar","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Akira","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Vinicius","family":"Ramos Souza","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Webby-Mears","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajakta","family":"Uday Joglekar","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Kunz","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Malhotra","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Krishna Gummuluri","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Sekeres","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Narayani","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Kinkead","sequence":"additional","affiliation":[{"name":"for the Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"joi250086r2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.5334\/gh.1280","article-title":"The burden of Chagas disease in the contemporary world: the RAISE study.","volume":"19","author":"Ribeiro","year":"2024","journal-title":"Glob Heart"},{"issue":"9678","key":"joi250086r3","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1016\/S0140-6736(09)61002-3","article-title":"Chagas disease: a neglected emergency.","volume":"373","year":"2009","journal-title":"Lancet"},{"issue":"10230","key":"joi250086r4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/S0140-6736(20)30171-9","article-title":"Chagas disease: still a neglected emergency?","volume":"395","author":"Lopes","year":"2020","journal-title":"Lancet"},{"issue":"12","key":"joi250086r5","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","article-title":"Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association.","volume":"138","author":"Nunes","year":"2018","journal-title":"Circulation"},{"issue":"5","key":"joi250086r6","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States.","volume":"49","author":"Bern","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"9","key":"joi250086r7","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.3201\/eid3109.241700","article-title":"Chagas disease, an endemic disease in the United States.","volume":"31","author":"Beatty","year":"2025","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"joi250086r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.07.009","article-title":"Climate change and Trypanosoma cruzi transmission in North and Central America.","volume":"5","author":"Forsyth","year":"2024","journal-title":"Lancet Microbe"},{"issue":"1-2","key":"joi250086r9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.actatropica.2009.07.019","article-title":"Chagas disease in Spain, the United States and other non-endemic countries.","volume":"115","author":"Gascon","year":"2010","journal-title":"Acta Trop"},{"key":"joi250086r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101040","article-title":"Prevalence of Chagas disease among Latin American immigrants in non-endemic countries: an updated systematic review and meta-analysis.","volume":"46","author":"Nepomuceno de Andrade","year":"2024","journal-title":"Lancet Reg Health Eur"},{"key":"joi250086r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2024.100681","article-title":"Prevalence of clinical forms of Chagas disease: a systematic review and meta-analysis\u2014data from the RAISE study.","volume":"30","author":"Nascimento","year":"2024","journal-title":"Lancet Reg Health Am"},{"issue":"12","key":"joi250086r12","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/s41569-024-01057-3","article-title":"Cardiac involvement in Chagas disease and African trypanosomiasis.","volume":"21","author":"Sabino","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"12","key":"joi250086r13","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1002\/ejhf.3460","article-title":"Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: unmasking a three-headed monster.","volume":"26","author":"Echeverr\u00eda","year":"2024","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"joi250086r14","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.jchf.2024.05.021","article-title":"Sacubitril\/valsartan versus enalapril in chronic Chagas cardiomyopathy: rationale and design of the PARACHUTE-HF trial.","volume":"12","author":"Bocchi","year":"2024","journal-title":"JACC Heart Fail"},{"issue":"4","key":"joi250086r15","first-page":"273","article-title":"Beneficial effects of enalapril on the diastolic ventricular function in Chagas myocardiopathy (in Portuguese).","volume":"60","author":"Szajnbok","year":"1993","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"joi250086r16","doi-asserted-by":"publisher","first-page":"976","DOI":"10.4269\/ajtmh.15-0237","article-title":"Enalapril in combination with benznidazole reduces cardiac inflammation and creatine kinases in mice chronically infected with Trypanosoma cruzi.","volume":"93","author":"Penitente","year":"2015","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"joi250086r17","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1080\/10543406.2017.1397007","article-title":"The stratified win ratio.","volume":"28","author":"Dong","year":"2018","journal-title":"J Biopharm Stat"},{"issue":"2","key":"joi250086r18","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1093\/eurheartj\/ehr352","article-title":"The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities.","volume":"33","author":"Pocock","year":"2012","journal-title":"Eur Heart J"},{"issue":"446","key":"joi250086r20","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk.","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"issue":"11","key":"joi250086r21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004361","article-title":"Contemporary characteristics and outcomes in Chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy.","volume":"10","author":"Shen","year":"2017","journal-title":"Circ Heart Fail"},{"key":"joi250086r22","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.70026","article-title":"Sacubitril\/valsartan versus enalapril in chronic Chagas cardiomyopathy with heart failure: baseline characteristics of the PARACHUTE-HF trial.","author":"Echeverria","year":"2025","journal-title":"Eur J Heart Fail"},{"issue":"21","key":"joi250086r23","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction.","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"issue":"15","key":"joi250086r24","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","article-title":"Cardiovascular and renal outcomes with empagliflozin in heart failure.","volume":"383","author":"Packer","year":"2020","journal-title":"N Engl J Med"},{"issue":"11","key":"joi250086r25","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure.","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"issue":"22","key":"joi250086r26","doi-asserted-by":"publisher","first-page":"e1054","DOI":"10.1161\/CIR.0000000000000490","article-title":"Role of biomarkers for the prevention, assessment, and management of heart failure: a scientific statement from the American Heart Association.","volume":"135","author":"Chow","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"joi250086r27","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/cpt.2222","article-title":"NT-proBNP qualifies as a surrogate for clinical end points in heart failure.","volume":"110","author":"Schmitt","year":"2021","journal-title":"Clin Pharmacol Ther"},{"issue":"22","key":"joi250086r28","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1016\/j.jacc.2016.09.931","article-title":"Prognostic implications of changes in N-terminal pro-B-type natriuretic peptide in patients with heart failure.","volume":"68","author":"Zile","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"joi250086r29","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/S0735-1097(02)02382-3","article-title":"Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudy.","volume":"40","author":"Rousseau","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"joi250086r30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011847","article-title":"Assessment of biomarkers and clinical parameters as predictors of survival in patients with Chagasic heart failure.","volume":"17","author":"Bocchi","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"joi250086r31","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1056\/NEJMoa1812851","article-title":"Angiotensin-neprilysin inhibition in acute decompensated heart failure.","volume":"380","author":"Velazquez","year":"2019","journal-title":"N Engl J Med"},{"issue":"7","key":"joi250086r32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131447","article-title":"Dysregulation of autonomic nervous system in Chagas\u2019 heart disease is associated with altered adipocytokines levels.","volume":"10","author":"Barbosa-Ferreira","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"joi250086r33","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.220112","article-title":"Detection of early diffuse myocardial fibrosis and inflammation in Chagas cardiomyopathy with T1 mapping and extracellular volume.","volume":"5","author":"Melo","year":"2023","journal-title":"Radiol Cardiothorac Imaging"},{"key":"joi250086r1","doi-asserted-by":"crossref","unstructured":"Cousin? E, Nascimento? BR, Mosser? J, . Global, regional, and national burden of Chagas disease, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. SSRN. August 7, 2025. Accessed October 2, 2025. https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=5381800","DOI":"10.2139\/ssrn.5381800"},{"key":"joi250086r19","unstructured":"Lin? DY, Wei? LJ, Yang? I, Ying? Z. Semiparametric regression for the mean and rate functions of recurrent events. JSTOR. 2000. Accessed October 2, 2025. https:\/\/www.jstor.org\/stable\/2680616"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2842283\/jama_lopes_2025_oi_250086_1769011125.74107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:00:21Z","timestamp":1769097621000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2842283"}},"subtitle":["An Open-Label, Multicenter Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2025.19808","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,6]]}}}