{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:37:12Z","timestamp":1791844632862,"version":"4.3.4"},"reference-count":26,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2026,2,10]]},"abstract":"\n Importance<\/jats:title>\n \n The most effective initial fraction of inspired oxygen (F\n io<\/jats:sc>\n 2<\/jats:sub>\n ) for resuscitating preterm newborns is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To compare outcomes of newborns born at 23 to 28 weeks\u2019 gestation resuscitated with initial F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.6 vs 0.3.\n <\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Randomized clinical trial conducted in 31 maternity hospitals in 6 countries. Consent by waiver was obtained in Australia, certain institutions in India, and Malaysia; prospective informed consent was obtained in certain institutions in India and all institutions in Singapore, Spain, and the US. Infants due at 23 to 28 weeks\u2019 gestation were randomized shortly before birth. Those with congenital abnormalities affecting oxygenation, neurodevelopment, or survival were excluded. Randomization was conducted from September 2018 to September 2024, with follow-up expected to close in September 2026.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n \n Infants were randomized (1:1) to receive an initial F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.6 or 0.3; F\n io<\/jats:sc>\n 2<\/jats:sub>\n was titrated to meet standard targets for oxygen saturation by pulse oximetry in the first 10 minutes or for clinical needs. Clinicians and those assessing outcomes were not blinded to group assignment.\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was death and brain injury at 36 weeks\u2019 corrected gestational age; secondary outcomes were the individual components of the primary outcome.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 1641 newborns were randomized. The primary analysis included 728 newborns randomized to receive an F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.6 and 741 to an F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.3 after excluding 172 newborns, mostly for birth after 28 weeks\u2019 gestation and transfer to another hospital before birth (54% female). Rates of escalation to F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 1.0 were similar between the groups (F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.6: 41%; F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.3: 38%). Primary outcome information was ascertained in 1423 newborns (96.9%). Death or brain injury at 36 weeks\u2019 corrected gestational age occurred in 330 of 703 newborns (46.9%) assigned to the F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.6 group vs 344 of 720 (47.8%) assigned to the F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.3 group (relative risk, 0.98 [95% CI, 0.89-1.09]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n \n Initiating resuscitation of preterm infants with F\n io<\/jats:sc>\n 2<\/jats:sub>\n of 0.6 vs 0.3 did not affect the risk of death or brain injury by 36 weeks\u2019 corrected gestational age. These results lay a foundation for future trials evaluating the effectiveness and safety of using higher initial F\n io<\/jats:sc>\n 2<\/jats:sub>\n levels for preterm infant resuscitation.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ANZCTR Identifier:\n ACTRN12618000879268<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2025.23327","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:30:19Z","timestamp":1765373419000},"page":"523","source":"Crossref","is-referenced-by-count":16,"title":["Targeted Oxygen for Initial Resuscitation of Preterm Infants"],"prefix":"10.1001","volume":"335","author":[{"given":"Ju Lee","family":"Oei","sequence":"first","affiliation":[{"name":"NHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia"},{"name":"Department of Newborn Care, the Royal Hospital for Women, Randwick, New South Wales, Australia"},{"name":"Discipline of Paediatrics and 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