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In 2023, there were 3882 cases of congenital syphilis in the US, including 279 congenital syphilis\u2013related stillbirths and neonatal\/infant deaths, the highest number reported in more than 30 years.<\/jats:p><\/jats:sec>Objective<\/jats:title>The US Preventive Services Task Force (USPSTF) commissioned a reaffirmation evidence update focused on the benefits and harms of screening for syphilis infection in pregnancy.<\/jats:p><\/jats:sec>Population<\/jats:title>Adolescents and adults who are pregnant.<\/jats:p><\/jats:sec>Evidence Assessment<\/jats:title>The USPSTF concludes with high certainty that screening for syphilis infection in pregnancy has a substantial net benefit.<\/jats:p><\/jats:sec>Recommendation<\/jats:title>The USPSTF recommends early, universal screening for syphilis infection during pregnancy; if an individual is not screened early in pregnancy, the USPSTF recommends screening at the first available opportunity. 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