{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:42:16Z","timestamp":1791520936647,"version":"4.3.4"},"reference-count":9,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:p>This cross-sectional study examines the proportion of US adults whose low-density lipoprotein cholesterol (LDL-C) levels exceed 2026 guidelines across risk categories and among individuals with atherosclerotic cardiovascular disease.<\/jats:p>","DOI":"10.1001\/jama.2026.10529","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:30:25Z","timestamp":1784561425000},"page":"605","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of LDL-C Above 2026 Dyslipidemia Guideline Goals Among US Adults"],"prefix":"10.1001","volume":"336","author":[{"given":"Shady","family":"Abohashem","sequence":"first","affiliation":[{"name":"Cardiology Department, Massachusetts General Hospital and Harvard Medical School, Boston"},{"name":"Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Hassan","sequence":"additional","affiliation":[{"name":"DeBakey Heart & Vascular Center, Houston Methodist Academic Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Mora","sequence":"additional","affiliation":[{"name":"Center for Lipid Metabolomics, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam R.","family":"Taub","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of California, San Diego School of Medicine, La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh K.","family":"Kalra","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"24","key":"jld260033r1","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel.","volume":"41","author":"Bor\u00e9n","year":"2020","journal-title":"Eur Heart J"},{"issue":"17","key":"jld260033r2","doi-asserted-by":"publisher","first-page":"e1154","DOI":"10.1161\/CIR.0000000000001423","article-title":"2026 ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines.","volume":"153","author":"Blumenthal","year":"2026","journal-title":"Circulation"},{"issue":"6","key":"jld260033r4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1161\/CIRCULATIONAHA.123.067626","article-title":"Development and validation of the American Heart Association\u2019s PREVENT equations.","volume":"149","author":"Khan","year":"2024","journal-title":"Circulation"},{"issue":"9","key":"jld260033r5","doi-asserted-by":"publisher","first-page":"e275","DOI":"10.1161\/CIR.0000000000001412","article-title":"2026 Heart disease and stroke statistics: a report of US and global data from the American Heart Association.","volume":"153","author":"Palaniappan","year":"2026","journal-title":"Circulation"},{"issue":"18","key":"jld260033r6","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.jacc.2022.02.048","article-title":"High-intensity statin use among patients with atherosclerosis in the US.","volume":"79","author":"Nelson","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"jld260033r7","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.jacc.2025.12.027","article-title":"Cardiovascular statistics in the United States, 2026.","volume":"87","author":"Wadhera","year":"2026","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"jld260033r8","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.25505","article-title":"Assessment of trends in statin therapy for secondary prevention of atherosclerotic cardiovascular disease in US adults from 2007 to 2016.","volume":"3","author":"Yao","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"8","key":"jld260033r9","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1161\/CIRCOUTCOMES.122.009787","article-title":"Gaps in guideline-based lipid-lowering therapy for secondary prevention in the United States: a retrospective cohort study of 322?153 patients.","volume":"16","author":"Navar","year":"2023","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"jld260033r3","unstructured":"National Center for Health Statistics. Brief overview of sample design, nonresponse bias assessment, and analytic guidelines for NHANES August 2021-August 2023. September 20, 2024. Accessed July 5, 2025. https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/continuousnhanes\/overviewbrief.aspx?Cycle=2021-2023"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2851798\/jama_abohashem_2026_ld_260033_1786039319.56256.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:05:26Z","timestamp":1787065526000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2851798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,8,18]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2026.10529","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}