{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:00:16Z","timestamp":1790092816602,"version":"4.0.1"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"\n Importance<\/jats:title>\n Small-for-gestational-age (SGA) infants face elevated risk of undernutrition and developmental delays. Multidomain interventions may be needed to promote growth and neurodevelopment.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the effect of an integrated intervention package on growth and neurodevelopment in term SGA infants.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Individually randomized clinical trial conducted in low-resource neighborhoods of South Delhi, India. Term SGA infants were enrolled within 14 days of birth; 1300 infants were randomized and followed up to 12 months of age. Recruitment occurred from January 14, 2023, until July 31, 2024, with follow-up completed on August 6, 2025. Outcome assessors were blinded to participant allocation.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Infants were randomized in a 1:1 ratio to receive either an integrated intervention package including health, nutrition, early child stimulation, and psychosocial support (n\u2009=\u2009647) or usual care through government programs (n\u2009=\u2009653).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n \n The primary outcomes were weight and weight-for-age\n z<\/jats:italic>\n score at 12 months. Secondary outcomes included linear growth, neurodevelopment (assessed using the Bayley Scales of Infant and Toddler Development, Third Edition), anemia, and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 12 months, 1261 infants (97%) (mean age, 6 days; 48.1% male) had completed follow-up. The mean weight was 8.0 kg (SD, 0.9 kg) in the intervention group vs 7.8 kg (SD, 0.9 kg) in the usual care group (mean difference, 0.22 kg [95% CI, 0.11-0.32 kg]). The mean weight-for-age\n z<\/jats:italic>\n score was \u22121.3 (SD, 0.9) vs \u22121.6 (SD, 1.0), respectively (mean difference, 0.24 [95% CI, 0.14-0.35]). The intervention group had a lower prevalence of underweight (23.9% vs 32.6%; risk difference, \u22128.75 [95% CI, \u221213.70 to \u22123.80] percentage points), stunting (20.1% vs 27.2%; risk difference, \u22127.17 [95% CI, \u221211.85 to \u22122.49] percentage points), wasting (13.9% vs 19.4%; risk difference, \u22125.52 [95% CI, \u22129.63 to \u22121.41] percentage points), and anemia (34.0% vs 72.5%; risk difference, \u221238.49 [95% CI, \u221244.36 to \u221232.61] percentage points) and higher cognitive scores (mean difference, 1.73 [95% CI, 0.32-3.14]), language scores (mean difference, 2.74 [95% CI, 1.51-3.98]), and motor composite scores (mean difference, 2.32 [95% CI, 1.25-3.38]). Nine children in the usual care group and 5 in the intervention group died.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n \n Among term SGA infants, an integrated intervention improved weight and weight-for-age\n z<\/jats:italic>\n scores at 12 months.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n Clinical Trials Registry\u2013India Identifier:\n CTRI\/2021\/11\/037881<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2026.12117","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:30:25Z","timestamp":1785166225000},"page":"1050","source":"Crossref","is-referenced-by-count":1,"title":["Multidomain Intervention for Growth in Term Small-for-Gestational-Age Infants"],"prefix":"10.1001","volume":"336","author":[{"given":"Ranadip","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Society for Applied Studies, New Delhi, 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