{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:30:07Z","timestamp":1790641807589,"version":"4.1.0"},"reference-count":34,"publisher":"American Medical Association (AMA)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"\n Importance<\/jats:title>\n Bronchoscopic biopsy is conventionally performed with forceps, which can result in small specimen sizes and poor specimen quality due to crush artifact. Cryoprobe use localizes freezing at the probe tip, enabling retrieval of larger, more intact biopsy specimens.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the diagnostic yield of a 1.1-mm cryoprobe for transbronchial biopsy.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This open-label, outcome assessor\u2013masked, multicenter randomized clinical trial included 500 patients aged 18 years or older scheduled to undergo transbronchial biopsy for lung nodules or masses, lung transplant, or diffuse parenchymal lung disease. The trial was conducted in 9 US medical centers and enrolled patients between February 27, 2023, and September 11, 2024. The date of last follow-up was October 12, 2024.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Patients were randomized 1:1 to transbronchial biopsy using a 1.1-mm cryoprobe (n\u2009=\u2009250) or 2.0-mm forceps (n\u2009=\u2009250).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was diagnostic yield, defined as the percentage of patients for whom the transbronchial biopsy sample led to a specific diagnosis based on histologic examination. Of the 8 prespecified secondary analyses, key secondary analyses were the diagnostic yield for each of the 3 conditions (lung nodules or masses, lung transplant, and diffuse parenchymal lung disease) and complication rates.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 774 patients assessed for eligibility, 609 provided consent, 500 were randomized, and 490 were included in the primary analysis; the mean age was 62.6 years (SD, 12.7 years) and 252 of 500 (50.4%) were male. The primary outcome of diagnostic yield was significantly higher in patients randomized to transbronchial biopsy with cryoprobes vs forceps (217 of 245 [88.6%] vs 193 of 245 [78.8%]; absolute difference, 9.8%; 95% CI, 3.3%-16.3%;\n P<\/jats:italic>\n \u2009=\u2009.003). For the key secondary analyses, compared with that of forceps, the diagnostic yield of cryoprobes was significantly higher among patients with pulmonary nodules or masses (79 of 95 [83.2%] vs 68 of 97 [70.1%]; absolute difference, 13.1%; 95% CI, 1.0%-24.6%;\n P<\/jats:italic>\n \u2009=\u2009.04) and lung transplant (120 of 125 [96.0%] vs 110 of 124 [88.7%]; absolute difference, 7.3%; 95% CI, 0.6%-14.4%;\n P<\/jats:italic>\n \u2009=\u2009.03) but did not differ significantly in diffuse parenchymal lung disease (18 of 25 [72.0%] vs 15 of 24 [62.5%]; absolute difference, 9.5%; 95% CI, \u221216.0% to 33.6%;\n P<\/jats:italic>\n \u2009=\u2009.55). For the secondary safety analysis, there were 4 pneumothoraces requiring chest tube placement in the forceps group (1.6%) vs none in the cryoprobe group; no patients experienced significant bleeding or respiratory failure events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Transbronchial lung biopsy performed with a 1.1-mm cryoprobe had a significantly higher diagnostic yield compared with 2.0-mm forceps in a group of patients with lung nodules or masses, lung transplant, and diffuse parenchymal lung disease.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT05751278<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.2026.7908","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:30:20Z","timestamp":1779121820000},"page":"2038","source":"Crossref","is-referenced-by-count":8,"title":["Cryobiopsy vs Forceps for Bronchoscopic Lung Biopsy"],"prefix":"10.1001","volume":"335","author":[{"given":"Jeffrey","family":"Thiboutot","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Kapp","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Illei","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Shofer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"DiBardino","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of Pennsylvania, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"DeMaio","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Sethi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momen M.","family":"Wahidi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan S.","family":"Benn","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Salmon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Angel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, University of Maryland, Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van K.","family":"Holden","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, University of Maryland, Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Paez","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Duke","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Lentz","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Vachani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of Pennsylvania, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Pastis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Molena","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Tackett","sequence":"additional","affiliation":[{"name":"Biostatistics, Epidemiology, and Data Management Core, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib M.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"},{"name":"Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonny","family":"Yarmus","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Interventional Pulmonary Outcomes Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Los","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Pai","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Christine","family":"Argento","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J","family":"Lee","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardian","family":"Latifi","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cicenia","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Machuzak","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gildea","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Almeida","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Shoajee","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Bridwell","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Kim","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Haas","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Lanfranco","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Mahmood","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Kim","sequence":"additional","affiliation":[{"name":"for the Interventional Pulmonary Outcomes Group"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"11","key":"joi260048r1","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/j.rmed.2012.08.008","article-title":"Population-based estimates of transbronchial lung biopsy utilization and complications.","volume":"106","author":"Tukey","year":"2012","journal-title":"Respir Med"},{"issue":"139","key":"joi260048r2","first-page":"1","article-title":"Ambulatory and inpatient procedures in the United States, 1996.","author":"Owings","year":"1998","journal-title":"Vital Health Stat 13"},{"issue":"3","key":"joi260048r3","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.chest.2019.10.016","article-title":"A prospective randomized comparative study of three guided bronchoscopic approaches for investigating pulmonary nodules: the PRECISION-1 study.","volume":"157","author":"Yarmus","year":"2020","journal-title":"Chest"},{"issue":"2","key":"joi260048r4","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.chest.2020.08.2047","article-title":"Robotic bronchoscopy for peripheral pulmonary lesions: a multicenter pilot and feasibility study (BENEFIT).","volume":"159","author":"Chen","year":"2021","journal-title":"Chest"},{"issue":"6","key":"joi260048r5","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.chest.2022.12.044","article-title":"Guided bronchoscopy for the evaluation of pulmonary lesions: an updated meta-analysis.","volume":"163","author":"Nadig","year":"2023","journal-title":"Chest"},{"issue":"2","key":"joi260048r6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1378\/chest.11-1764","article-title":"Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule.","volume":"142","author":"Wang Memoli","year":"2012","journal-title":"Chest"},{"issue":"5","key":"joi260048r7","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.chest.2018.08.1026","article-title":"Standard bronchoscopy with fluoroscopy vs thin bronchoscopy and radial endobronchial ultrasound for biopsy of pulmonary lesions: a multicenter, prospective, randomized trial.","volume":"154","author":"Tanner","year":"2018","journal-title":"Chest"},{"issue":"1","key":"joi260048r8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1164\/rccm.201507-1332OC","article-title":"Diagnostic yield and complications of bronchoscopy for peripheral lung lesions: results of the AQuIRE registry.","volume":"193","author":"Ost","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"joi260048r9","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1378\/chest.07-0637","article-title":"Factors related to diagnostic yield of transbronchial biopsy using endobronchial ultrasonography with a guide sheath in small peripheral pulmonary lesions.","volume":"132","author":"Yamada","year":"2007","journal-title":"Chest"},{"issue":"6","key":"joi260048r10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1513\/AnnalsATS.201610-829OC","article-title":"High complication rate after introduction of transbronchial cryobiopsy into clinical practice at an academic medical center.","volume":"14","author":"DiBardino","year":"2017","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"joi260048r11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.chest.2016.01.018","article-title":"A randomized controlled trial of a novel sheath cryoprobe for bronchoscopic lung biopsy in a porcine model.","volume":"150","author":"Yarmus","year":"2016","journal-title":"Chest"},{"key":"joi260048r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2026.03.027","article-title":"Procedural techniques, airway management and specimen acquisition for peripheral lung transbronchial and endobronchial ultrasound guided cryobiopsy: a modified Delphi consensus statement.","author":"Beattie","year":"2026","journal-title":"Chest"},{"issue":"12","key":"joi260048r13","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1159\/000526876","article-title":"Safety and feasibility of a sheath cryoprobe for bronchoscopic transbronchial biopsy: the FROSTBITE trial.","volume":"101","author":"Thiboutot","year":"2022","journal-title":"Respiration"},{"issue":"3","key":"joi260048r14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1378\/chest.12-2290","article-title":"Cryoprobe transbronchial lung biopsy in patients after lung transplantation: a pilot safety study.","volume":"143","author":"Yarmus","year":"2013","journal-title":"Chest"},{"issue":"22","key":"joi260048r15","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1001\/jama.2025.4347","article-title":"CONSORT 2025 statement: updated guideline for reporting randomized trials.","volume":"333","author":"Hopewell","year":"2025","journal-title":"JAMA"},{"key":"joi260048r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2026.108251","article-title":"A randomized controlled trial of cryoprobe versus forceps for transbronchial biopsy (FROSTBITE-2): study protocol for a multi-center pragmatic clinical trial.","volume":"162","author":"Thiboutot","year":"2026","journal-title":"Contemp Clin Trials"},{"key":"joi260048r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap Consortium: building an international community of software platform partners.","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"2","key":"joi260048r18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support.","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"joi260048r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2025.104925","article-title":"A REDCap advanced randomization module to meet the needs of modern trials.","volume":"171","author":"Stevens","year":"2025","journal-title":"J Biomed Inform"},{"issue":"12","key":"joi260048r20","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.healun.2007.10.017","article-title":"Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection.","volume":"26","author":"Stewart","year":"2007","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"joi260048r21","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.gie.2012.12.013","article-title":"A novel flexible cryoprobe for EUS-guided pancreatic biopsies.","volume":"77","author":"von Renteln","year":"2013","journal-title":"Gastrointest Endosc"},{"issue":"6","key":"joi260048r22","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1164\/rccm.202401-0192ST","article-title":"Assessment of advanced diagnostic bronchoscopy outcomes for peripheral lung lesions: a Delphi consensus definition of diagnostic yield and recommendations for patient-centered study designs: an official American Thoracic Society\/American College of Chest Physicians research statement.","volume":"209","author":"Gonzalez","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"joi260048r23","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00158-2025","article-title":"Update of the international multidisciplinary classification of the interstitial pneumonias: an ERS\/ATS statement.","volume":"66","author":"Ryerson","year":"2025","journal-title":"Eur Respir J"},{"issue":"1","key":"joi260048r24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1183\/09031936.00011313","article-title":"Endobronchial ultrasound-guided cryobiopsies in peripheral pulmonary lesions: a feasibility study.","volume":"43","author":"Schuhmann","year":"2014","journal-title":"Eur Respir J"},{"issue":"4","key":"joi260048r25","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1164\/rccm.201910-1915OC","article-title":"Risk factors for acute rejection in the first year after lung transplant: a multicenter study.","volume":"202","author":"Todd","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"joi260048r26","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1159\/000203987","article-title":"Transbronchial cryobiopsy: a new tool for lung biopsies.","volume":"78","author":"Babiak","year":"2009","journal-title":"Respiration"},{"issue":"9","key":"joi260048r27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239114","article-title":"Transbronchial biopsy results according to diffuse interstitial lung disease classification: cryobiopsy versus forceps: MULTICRIO study.","volume":"15","author":"Pajares","year":"2020","journal-title":"PLoS One"},{"issue":"6","key":"joi260048r28","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1111\/resp.12322","article-title":"Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: a randomized trial.","volume":"19","author":"Pajares","year":"2014","journal-title":"Respirology"},{"issue":"2","key":"joi260048r29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S2213-2600(19)30342-X","article-title":"Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study.","volume":"8","author":"Troy","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"10","key":"joi260048r30","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1164\/rccm.201810-1947OC","article-title":"Poor concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in the diagnosis of diffuse interstitial lung diseases.","volume":"199","author":"Romagnoli","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"joi260048r31","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.chest.2019.10.048","article-title":"Transbronchial cryobiopsy for the diagnosis of interstitial lung diseases: CHEST guideline and expert panel report.","volume":"157","author":"Maldonado","year":"2020","journal-title":"Chest"},{"issue":"12","key":"joi260048r32","doi-asserted-by":"publisher","first-page":"11028","DOI":"10.21037\/jtd-2025-1711","article-title":"Evaluation of 1.1 mm ultrathin cryobiopsy through a guide sheath for sampling of peripheral pulmonary lesions.","volume":"17","author":"Ochiai","year":"2025","journal-title":"J Thorac Dis"},{"key":"joi260048r33","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108061","article-title":"Comparing the 1.1 mm cryoprobe versus flexible forceps for lung transplant acute allograft rejection diagnosis.","volume":"241","author":"Balasubramanian","year":"2025","journal-title":"Respir Med"},{"issue":"1","key":"joi260048r34","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2026.2613456","article-title":"Comparative study of transbronchial cryobiopsy and transbronchial biopsy for diagnostic yield in peripheral pulmonary lesions.","volume":"58","author":"Chang","year":"2026","journal-title":"Ann Med"}],"container-title":["JAMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/articlepdf\/2849314\/jama_thiboutot_2026_oi_260048_1780943374.55371.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:00:45Z","timestamp":1781622045000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2849314"}},"subtitle":["The FROSTBITE-2 Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":34,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1001\/jama.2026.7908","relation":{},"ISSN":["0098-7484"],"issn-type":[{"value":"0098-7484","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}