{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:47:24Z","timestamp":1790351244893,"version":"4.1.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA"],"published-print":{"date-parts":[[2003,4,2]]},"abstract":"\n Context<\/jats:title>\n Humans are exposed to methylmercury, a well-established neurotoxin, through fish consumption. The fetus is most sensitive to the adverse effects of exposure. The extent of exposure to methylmercury in US women of reproductive age is not known.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To describe the distribution of blood mercury levels in US children and women of childbearing age and the association with sociodemographic characteristics and fish consumption.<\/jats:p>\n <\/jats:sec>\n \n Design and Setting<\/jats:title>\n The 1999-2000 data from the National Health and Nutrition Examination Survey, a cross-sectional survey of the noninstitutionalized US population.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n In 1999-2000, 1250 children aged 1 to 5 years and 2314 women aged 16 to 49 years were selected to participate in the survey. Household interviews, physical examinations, and blood mercury levels assessments were performed on 705 children (56% response rate) and 1709 women (74% response rate).<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measure<\/jats:title>\n Blood concentration of total mercury.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Blood mercury levels were approximately 3-fold higher in women compared with children. The geometric mean concentration of total blood mercury was 0.34 \u00b5g\/L (95% confidence interval [CI], 0.30-0.39 \u00b5g\/L) in children and 1.02 \u00b5g\/L (95% CI, 0.85-1.20 \u00b5g\/L) in women. Geometric mean mercury levels were almost 4-fold higher among women who ate 3 or more servings of fish in the past 30 days compared with women who ate no fish in that period (1.94 \u00b5g\/L vs 0.51 \u00b5g\/L;\n P<\/jats:italic>\n &amp;lt;.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Measures of mercury exposure in women of childbearing age and young children generally fall below levels of concern. However, approximately 8% of women had concentrations higher than the US Environmental Protection Agency's recommended reference dose (5.8 \u00b5g\/L), below which exposures are considered to be without adverse effects. Women who are pregnant or who intend to become pregnant should follow federal and state advisories on consumption of fish.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jama.289.13.1667","type":"journal-article","created":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T16:43:58Z","timestamp":1049215438000},"page":"1667","source":"Crossref","is-referenced-by-count":252,"title":["Blood Mercury Levels in US Children and Women of Childbearing Age, 1999-2000"],"prefix":"10.1001","volume":"289","author":[{"given":"Susan E.","family":"Schober","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Sinks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Michael","family":"Bolger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"McDowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Osterloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Spencer","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Canady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"Mahaffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"key":"ref-joc21646-4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/phr\/114.5.397","article-title":"Methylmercury: a new look at the 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Soc"},{"key":"ref-joc21646-19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3109\/15563659709043370","article-title":"Concentrations of blood and hair mercury and serum PCBs in an Ojibwa population that consumes Great Lakes Region fish.","volume":"35","author":"Gerstenberger","year":"1997","journal-title":"J Toxicol Clin Toxicol"},{"key":"ref-joc21646-20","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1289\/ehp.95103604","article-title":"Imported seabass as a source of mercury exposure: a Wisconsin case study.","volume":"103","author":"Knobeloch","year":"1995","journal-title":"Environ Health Perspect"},{"key":"ref-joc21646-21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1080\/00039890109604048","article-title":"Mercury and methylmercury exposure in the New Jersey pregnant population.","volume":"56","author":"Stern","year":"2001","journal-title":"Arch Environ Health"},{"key":"ref-joc21646-22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00043764-200202000-00009","article-title":"Mercury exposure: current concepts, controversies, and a clinic's experience.","volume":"44","author":"Kales","year":"2002","journal-title":"J Occup Environ Med"},{"key":"ref-joc21646-24","first-page":"176","article-title":"Determination of total and inorganic mercury in whole blood by on-line digestion with flow injection.","volume":"19","author":"Chen","year":"1998","journal-title":"Atomic Spectroscopy"},{"key":"ref-joc21646-26","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0048-9697(91)90380-W","article-title":"A review of normal concentrations of mercury in human blood.","volume":"100","author":"Brune","year":"1991","journal-title":"Sci Total Environ"},{"key":"ref-joc21646-27","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/sj.jea.7500111","article-title":"The German Environmental Survey 1990\/1992 (GER 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distribution.","volume":"19","author":"Aberg","year":"1969","journal-title":"Arch Environ Health"},{"key":"ref-joc21646-32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/096032718400300205","article-title":"Elevation of mercury in human blood from controlled chronic ingestion of methylmercury in fish.","volume":"3","author":"Sherlock","year":"1984","journal-title":"Hum Toxicol"},{"key":"ref-joc21646-33","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/S0140-6736(02)11682-5","article-title":"Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive study.","volume":"360","author":"Pichichero","year":"2002","journal-title":"Lancet"},{"key":"ref-joc21646-35","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1161\/01.CIR.0000038493.65177.94","article-title":"Fish consumption, fish oil, omega-3 fatty acids and cardiovascular disease.","volume":"106","author":"Kris-Etherton","year":"2002","journal-title":"Circulation"},{"key":"ref-joc21646-1","volume-title":"Mercury Study Report to Congress, Volume I: Executive Summary","author":"US Environmental Protection Agency","year":"1997"},{"key":"ref-joc21646-2","volume-title":"Toxicological Profile for Mercury [update]","author":"Agency for Toxic Substances and Disease Registries","year":"1999"},{"key":"ref-joc21646-3","volume-title":"Toxicological Effects of Methylmercury","author":"National Academy of Sciences","year":"2000"},{"key":"ref-joc21646-5","volume-title":"Environmental Health Criteria 101: Methylmercury","author":"World Health Organization","year":"1990"},{"key":"ref-joc21646-7","volume-title":"Minamata Disease","author":"Tsubaki","year":"1977"},{"key":"ref-joc21646-12","volume-title":"Physical and Mental Development of Children With Prenatal Exposure to Mercury From Fish, Stage II: Interviews and Psychological Tests at Age 6","author":"Kjellstrom","year":"1989"},{"key":"ref-joc21646-17","volume-title":"Biological Monitoring of Metals: Chemical Safety Monographs: International Programme on Chemical Safety","author":"Elinder","year":"1994"},{"key":"ref-joc21646-31","first-page":"233","article-title":"Absorption and elimination of dietary (Hg++) and methylmercury in man.","volume-title":"Mercury, Mercurials, and Mercaptans","author":"Miettinen","year":"1973"},{"key":"ref-joc21646-34","volume-title":"National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource","author":"Hall","year":"1978"},{"key":"ref-joc21646-13","unstructured":"Center for Food Safety and Applied Nutrition, US Food and Drug Administration. An important message for pregnant women and women of childbearing age who may become pregnant about the risks of mercury in fish. Available at: http:\/\/vm.cfsan.fda.gov\/~dms\/admehg.html. Accessed June 26, 2002."},{"key":"ref-joc21646-14","unstructured":"Canada Food Inspection Fact Sheet. Food safety facts on mercury and fish consumption. Available at: http:\/\/www.inspection.gc.ca\/english\/corpaffr\/foodfacts\/mercurye.shtml. Accessed June 26, 2002."},{"key":"ref-joc21646-15","unstructured":"Food Standards Agency. Agency updates advice to pregnant and breastfeeding women on eating certain fish. Available at: http:\/\/www.foodstandards.gov.uk\/news\/pressreleases\/tuna_mercury. Accessed February 26, 2003."},{"key":"ref-joc21646-16","unstructured":"US Environmental Protection Agency. Fish advisories. Available at: http:\/\/www.epa.gov\/ost\/fish\/. Accessed July 3, 2002."},{"key":"ref-joc21646-23","unstructured":"National Center for Health Statistics. National Health and Nutrition Examination Survey. Available at: http:\/\/www.cdc.gov\/nchs\/nhanes.htm. Accessed June 27, 2002."},{"key":"ref-joc21646-25","unstructured":"Centers for Disease Control and Prevention. Second national report on human exposure to environmental chemicals. Available at: http:\/\/www.cdc.gov\/exposurereport\/\/. 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