{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:15:44Z","timestamp":1790295344503,"version":"4.1.0"},"reference-count":48,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.1001\/jamacardio.2017.4293","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T12:32:45Z","timestamp":1511958765000},"page":"26","source":"Crossref","is-referenced-by-count":128,"title":["Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm"],"prefix":"10.1001","volume":"3","author":[{"given":"Seamus C.","family":"Harrison","sequence":"first","affiliation":[{"name":"Cambridge Vascular Unit, Addenbrookes Hospital, Cambridge, England"},{"name":"Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England"},{"name":"Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England"},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Burgess","sequence":"additional","affiliation":[{"name":"Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, England"},{"name":"Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert W.","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Medical Genetics, Centre for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette F.","family":"Baas","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Centre for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N.","family":"van \u2019t Hof","sequence":"additional","affiliation":[{"name":"Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I. W.","family":"de Bakker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Medical Genetics, Centre for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D.","family":"Blankensteijn","sequence":"additional","affiliation":[{"name":"Department of Surgery, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet T.","family":"Powell","sequence":"additional","affiliation":[{"name":"Vascular Surgery Research Group, Imperial College Charing Cross Hospital, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Saratzis","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University of Leicester, Leicester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert J.","family":"de Borst","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London, England"},{"name":"Department of Medicine, Imperial College London, Hammersmith Hospital, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"van der Graaf","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre M.","family":"van Rij","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Carey","sequence":"additional","affiliation":[{"name":"Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Elmore","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Geisinger Health System, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Tromp","sequence":"additional","affiliation":[{"name":"Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania"},{"name":"Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Kuivaniemi","sequence":"additional","affiliation":[{"name":"Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania"},{"name":"Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Sayers","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University of Leicester, Leicester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh J.","family":"Samani","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University of Leicester, Leicester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Bown","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University of Leicester, Leicester, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve E.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"5","key":"hoi170066r1","first-page":"891","article-title":"The impact of gender on presentation, therapy, and mortality of abdominal aortic aneurysm in the United States, 2001-2004. J Vasc Surg.","volume":"45","author":"McPhee","year":"2007"},{"issue":"9345","key":"hoi170066r2","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0140-6736(02)11522-4","article-title":"The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial.","volume":"360","author":"Ashton","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"hoi170066r3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.7326\/M14-1204","article-title":"Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommendation statement.","volume":"161","author":"LeFevre","year":"2014","journal-title":"Ann Intern Med"},{"issue":"9932","key":"hoi170066r5","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1\u00b725 million people.","volume":"383","author":"Rapsomaniki","year":"2014","journal-title":"Lancet"},{"issue":"2","key":"hoi170066r6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S2213-8587(14)70219-0","article-title":"Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1\u00b79 million people.","volume":"3","author":"Shah","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"hoi170066r7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/ije\/dyu218","article-title":"Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1?937?360 people in England: lifetime risks and implications for risk prediction.","volume":"44","author":"Pujades-Rodriguez","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"2","key":"hoi170066r8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/ng.72","article-title":"The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.","volume":"40","author":"Helgadottir","year":"2008","journal-title":"Nat Genet"},{"issue":"8","key":"hoi170066r9","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/ng.622","article-title":"Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.","volume":"42","author":"Gretarsdottir","year":"2010","journal-title":"Nat Genet"},{"issue":"5","key":"hoi170066r10","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1161\/CIRCGENETICS.113.000165","article-title":"A variant in LDLR is associated with abdominal aortic aneurysm.","volume":"6","author":"Bradley","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"issue":"14","key":"hoi170066r11","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1093\/hmg\/ddt141","article-title":"A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm.","volume":"22","author":"Jones","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"48","key":"hoi170066r12","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1093\/eurheartj\/ehs354","article-title":"Interleukin-6 receptor pathways in abdominal aortic aneurysm.","volume":"34","author":"Harrison","year":"2013","journal-title":"Eur Heart J"},{"issue":"5","key":"hoi170066r13","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.ajhg.2011.10.002","article-title":"Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.","volume":"89","author":"Bown","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"2","key":"hoi170066r14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.308765","article-title":"Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci.","volume":"120","author":"Jones","year":"2017","journal-title":"Circ Res"},{"issue":"9411","key":"hoi170066r15","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0140-6736(04)15690-0","article-title":"Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20?536 people with cerebrovascular disease or other high-risk conditions.","volume":"363","author":"Collins","year":"2004","journal-title":"Lancet"},{"issue":"11","key":"hoi170066r16","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/ng.2795","article-title":"Common variants associated with plasma triglycerides and risk for coronary artery disease.","volume":"45","author":"Do","year":"2013","journal-title":"Nat Genet"},{"issue":"9726","key":"hoi170066r17","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/S0140-6736(10)60545-4","article-title":"Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies","volume":"375","author":"Sarwar","year":"2010","journal-title":"Lancet"},{"issue":"6","key":"hoi170066r18","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1001\/jamacardio.2016.1884","article-title":"Association of lipid fractions with risks for coronary artery disease and diabetes.","volume":"1","author":"White","year":"2016","journal-title":"JAMA Cardiol"},{"issue":"9841","key":"hoi170066r19","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(12)60312-2","article-title":"Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.","volume":"380","author":"Voight","year":"2012","journal-title":"Lancet"},{"issue":"21","key":"hoi170066r20","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","article-title":"Effects of torcetrapib in patients at high risk for coronary events.","volume":"357","author":"Barter","year":"2007","journal-title":"N Engl J Med"},{"issue":"22","key":"hoi170066r21","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1056\/NEJMoa1206797","article-title":"Effects of dalcetrapib in patients with a recent acute coronary syndrome.","volume":"367","author":"Schwartz","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"hoi170066r22","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.jvs.2010.02.283","article-title":"A further meta-analysis of population-based screening for abdominal aortic aneurysm.","volume":"52","author":"Takagi","year":"2010","journal-title":"J Vasc Surg"},{"issue":"5","key":"hoi170066r23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.amjcard.2010.06.021","article-title":"A meta-analysis of association between serum lipoproteins and abdominal aortic aneurysm.","volume":"106","author":"Takagi","year":"2010","journal-title":"Am J Cardiol"},{"issue":"8","key":"hoi170066r24","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1161\/CIRCULATIONAHA.107.720219","article-title":"Abdominal aortic aneurysms, increasing infrarenal aortic diameter, and risk of total mortality and incident cardiovascular disease events: 10-year follow-up data from the Cardiovascular Health Study.","volume":"117","author":"Freiberg","year":"2008","journal-title":"Circulation"},{"issue":"12","key":"hoi170066r25","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1002\/bjs.10269","article-title":"Cardiovascular risk prevention and all-cause mortality in primary care patients with an abdominal aortic aneurysm.","volume":"103","author":"Bahia","year":"2016","journal-title":"Br J Surg"},{"issue":"2","key":"hoi170066r26","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/MAJ.0000000000000292","article-title":"Statin underuse and low prevalence of LDL-C control among U.S. adults at high risk of coronary heart disease.","volume":"348","author":"Gamboa","year":"2014","journal-title":"Am J Med Sci"},{"issue":"3","key":"hoi170066r27","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1161\/CIRCGENETICS.113.000022","article-title":"Impact of inherited genetic variants associated with lipid profile, hypertension, and coronary artery disease on the risk of intracranial and abdominal aortic aneurysms.","volume":"6","author":"van 't Hof","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"issue":"9501","key":"hoi170066r28","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1016\/S0140-6736(05)67767-7","article-title":"Nature\u2019s randomised trials.","volume":"366","author":"Hingorani","year":"2005","journal-title":"Lancet"},{"issue":"9965","key":"hoi170066r29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0140-6736(14)61183-1","article-title":"HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.","volume":"385","author":"Swerdlow","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"hoi170066r30","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1161\/CIRCULATIONAHA.109.865444","article-title":"Separating the mechanism-based and off-target actions of CETP-inhibitors with CETP gene polymorphisms.","volume":"121","author":"Sofat","year":"2010","journal-title":"Circulation"},{"issue":"4","key":"hoi170066r31","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.2016.40.issue-4","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator.","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"2","key":"hoi170066r32","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"11","key":"hoi170066r33","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels.","volume":"45","author":"Willer","year":"2013","journal-title":"Nat Genet"},{"issue":"4","key":"hoi170066r34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects.","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"key":"hoi170066r35","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyx034","article-title":"MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data.","author":"Yavorska","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"9","key":"hoi170066r36","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/eurheartj\/eht571","article-title":"Mendelian randomization of blood lipids for coronary heart disease.","volume":"36","author":"Holmes","year":"2015","journal-title":"Eur Heart J"},{"issue":"10","key":"hoi170066r37","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrcardio.2017.78","article-title":"Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.","volume":"14","author":"Holmes","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"18","key":"hoi170066r38","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease.","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"},{"issue":"2","key":"hoi170066r39","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S2213-8587(16)30396-5","article-title":"PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.","volume":"5","author":"Schmidt","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"17","key":"hoi170066r40","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1001\/jama.2014.13959","article-title":"Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.","volume":"312","author":"Smith","year":"2014","journal-title":"JAMA"},{"issue":"349","key":"hoi170066r41","doi-asserted-by":"publisher","first-page":"349ps15","DOI":"10.1126\/scitranslmed.aaf2608","article-title":"Disciplined approach to drug discovery and early development.","volume":"8","author":"Plenge","year":"2016","journal-title":"Sci Transl Med"},{"key":"hoi170066r42","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1186\/1471-2164-15-S4-S5","article-title":"GWAS and drug targets.","volume":"15","author":"Cao","year":"2014","journal-title":"BMC Genomics"},{"issue":"10","key":"hoi170066r43","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.amjcard.2009.12.076","article-title":"Association between serum lipoproteins and abdominal aortic aneurysm.","volume":"105","author":"Golledge","year":"2010","journal-title":"Am J Cardiol"},{"issue":"16","key":"hoi170066r44","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.108.817619","article-title":"Risk factors for abdominal aortic aneurysms: a 7-year prospective study: the Troms\u00f8 Study, 1994-2001.","volume":"119","author":"Forsdahl","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"hoi170066r45","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1056\/NEJMoa1300955","article-title":"Effects of extended-release niacin with laropiprant in high-risk patients.","volume":"371","author":"HPS THRIVE Collaborative Group","year":"2014","journal-title":"N Engl J Med"},{"issue":"9802","key":"hoi170066r46","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/S0140-6736(11)61383-4","article-title":"Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial.","volume":"378","author":"Fayad","year":"2011","journal-title":"Lancet"},{"issue":"7","key":"hoi170066r47","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization.","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"3","key":"hoi170066r48","doi-asserted-by":"publisher","first-page":"e1002607","DOI":"10.1371\/journal.pgen.1002607","article-title":"Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.","volume":"8","author":"Dastani","year":"2012","journal-title":"PLoS Genet"},{"key":"hoi170066r4","unstructured":"National Health Service. Abdominal aortic aneurysm screening. http:\/\/www.nhs.uk\/conditions\/abdominal-aortic-aneurysm-screening\/Pages\/Introduction.aspx. Published July 24, 2017. Accessed October 24, 2017."}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamacardiology\/article-pdf\/3\/1\/26\/17683752\/jamacardiology_harrison_2017_oi_170066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T17:44:25Z","timestamp":1561484665000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiology.jamanetwork.com\/article.aspx?doi=10.1001\/jamacardio.2017.4293"}},"subtitle":["A Meta-analysis"],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2017.4293","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,1]]}}}