{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:35:58Z","timestamp":1793730958321,"version":"4.6.1"},"reference-count":34,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1001\/jamacardio.2018.1470","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T19:06:22Z","timestamp":1529521582000},"page":"619","source":"Crossref","is-referenced-by-count":671,"title":["Association of<i>LPA<\/i>Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies"],"prefix":"10.1001","volume":"3","author":[{"given":"Stephen","family":"Burgess","sequence":"first","affiliation":[{"name":"Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom"},{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Ference","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"School of Medicine, Wayne State University, Detroit, Michigan"},{"name":"Institute for Advanced Studies, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Staley","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Freitag","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Mason","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune F.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Willeit","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"Department of Neurology, Medizinische Universit\u00e4t Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Young","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Surendran","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Bolton","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Peters","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia R.","family":"Kamstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tybj\u00e6rg-Hansen","sequence":"additional","affiliation":[{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Benn","sequence":"additional","affiliation":[{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Langsted","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Vedel-Krogh","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla J.","family":"Kobylecki","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Ford","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Packard","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Trompet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands"},{"name":"Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands"},{"name":"Netherlands Heart Institute, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Di Angelantonio","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Saleheen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia"},{"name":"Centre for Non-Communicable Diseases, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M. M.","family":"Howson","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Butterworth","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Danesh","sequence":"additional","affiliation":[{"name":"MRC\/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom"},{"name":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the European Prospective Investigation Into Cancer and Nutrition\u2013Cardiovascular Disease (EPIC-CVD) Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"12A","key":"hoi180024r1","doi-asserted-by":"publisher","first-page":"57U","DOI":"10.1016\/S0002-9149(98)00954-0","article-title":"Lipoprotein(a) as a risk factor for coronary artery disease.","volume":"82","author":"Marcovina","year":"1998","journal-title":"Am J Cardiol"},{"issue":"4","key":"hoi180024r2","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1001\/jama.2009.1063","article-title":"Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.","volume":"302","author":"Erqou","year":"2009","journal-title":"JAMA"},{"issue":"22","key":"hoi180024r3","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1001\/jama.2009.801","article-title":"Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.","volume":"301","author":"Kamstrup","year":"2009","journal-title":"JAMA"},{"issue":"26","key":"hoi180024r4","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1056\/NEJMoa0902604","article-title":"Genetic variants associated with Lp(a) lipoprotein level and coronary disease.","volume":"361","author":"Clarke","year":"2009","journal-title":"N Engl J Med"},{"issue":"11","key":"hoi180024r5","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1194\/jlr.R071233","article-title":"Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.","volume":"57","author":"Nordestgaard","year":"2016","journal-title":"J Lipid Res"},{"issue":"24","key":"hoi180024r6","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMoa1107579","article-title":"Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.","volume":"365","author":"Boden","year":"2011","journal-title":"N Engl J Med"},{"issue":"3","key":"hoi180024r7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1056\/NEJMoa1300955","article-title":"Effects of extended-release niacin with laropiprant in high-risk patients.","volume":"371","author":"Landray","year":"2014","journal-title":"N Engl J Med"},{"issue":"21","key":"hoi180024r8","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","article-title":"Effects of torcetrapib in patients at high risk for coronary events.","volume":"357","author":"Barter","year":"2007","journal-title":"N Engl J Med"},{"issue":"20","key":"hoi180024r9","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1056\/NEJMoa1609581","article-title":"Evacetrapib and cardiovascular outcomes in high-risk vascular disease.","volume":"376","author":"Lincoff","year":"2017","journal-title":"N Engl J Med"},{"issue":"13","key":"hoi180024r10","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1056\/NEJMoa1706444","article-title":"Effects of anacetrapib in patients with atherosclerotic vascular disease.","volume":"377","author":"Bowman","year":"2017","journal-title":"N Engl J Med"},{"issue":"18","key":"hoi180024r11","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease.","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"},{"issue":"10057","key":"hoi180024r12","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/S0140-6736(16)31009-1","article-title":"Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.","volume":"388","author":"Viney","year":"2016","journal-title":"Lancet"},{"issue":"23","key":"hoi180024r13","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1093\/eurheartj\/ehq386","article-title":"Lipoprotein(a) as a cardiovascular risk factor: current status.","volume":"31","author":"Nordestgaard","year":"2010","journal-title":"Eur Heart J"},{"issue":"6","key":"hoi180024r14","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1001\/archinte.168.6.598","article-title":"Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data.","volume":"168","author":"Bennet","year":"2008","journal-title":"Arch Intern Med"},{"issue":"25","key":"hoi180024r15","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1016\/j.jacc.2016.10.033","article-title":"Phenotypic characterization of genetically lowered human lipoprotein(a) levels.","volume":"68","author":"Emdin","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"hoi180024r16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/CIRCULATIONAHA.107.715698","article-title":"Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study.","volume":"117","author":"Kamstrup","year":"2008","journal-title":"Circulation"},{"issue":"9753","key":"hoi180024r17","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.","volume":"376","author":"Baigent","year":"2010","journal-title":"Lancet"},{"issue":"9841","key":"hoi180024r18","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.","volume":"380","author":"Mihaylova","year":"2012","journal-title":"Lancet"},{"issue":"12","key":"hoi180024r19","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1001\/jama.2016.13985","article-title":"Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis.","volume":"316","author":"Silverman","year":"2016","journal-title":"JAMA"},{"issue":"7307","key":"hoi180024r20","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids.","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"issue":"11","key":"hoi180024r21","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1002\/sim.v35.11","article-title":"Combining information on multiple instrumental variables in mendelian randomization: comparison of allele score and summarized data methods.","volume":"35","author":"Burgess","year":"2016","journal-title":"Stat Med"},{"issue":"4","key":"hoi180024r22","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/gepi.2017.41.issue-4","article-title":"Semiparametric methods for estimation of a nonlinear exposure-outcome relationship using instrumental variables with application to mendelian randomization.","volume":"41","author":"Staley","year":"2017","journal-title":"Genet Epidemiol"},{"issue":"10","key":"hoi180024r23","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary artery disease.","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat Genet"},{"issue":"1","key":"hoi180024r24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1172\/JCI115855","article-title":"Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations.","volume":"90","author":"Boerwinkle","year":"1992","journal-title":"J Clin Invest"},{"issue":"18","key":"hoi180024r25","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apolipoproteins, and risk of vascular disease.","volume":"302","author":"Di Angelantonio","year":"2009","journal-title":"JAMA"},{"issue":"15","key":"hoi180024r26","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.jacc.2015.02.020","article-title":"Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 \u00d7 2 factorial mendelian randomization study.","volume":"65","author":"Ference","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"hoi180024r27","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1056\/NEJMoa1604304","article-title":"Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes.","volume":"375","author":"Ference","year":"2016","journal-title":"N Engl J Med"},{"issue":"8934","key":"hoi180024r28","first-page":"1383","article-title":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).","volume":"344","author":"Pedersen","year":"1994","journal-title":"Lancet"},{"issue":"2","key":"hoi180024r29","doi-asserted-by":"crossref","first-page":"e001696","DOI":"10.1161\/CIRCGEN.117.001696","article-title":"Impact of apolipoprotein(a) isoform size on lipoprotein(a) lowering in the HPS2-THRIVE study.","volume":"11","author":"Parish","year":"2018","journal-title":"Circ Genom Precis Med"},{"issue":"10","key":"hoi180024r30","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1001\/jama.2017.11467","article-title":"Association of genetic variants related to CETP inhibitors and statins with lipoprotein levels and cardiovascular risk.","volume":"318","author":"Ference","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"hoi180024r31","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/eurheartj\/ehx462","article-title":"How to use mendelian randomization to anticipate the results of randomized trials.","volume":"39","author":"Ference","year":"2018","journal-title":"Eur Heart J"},{"issue":"11","key":"hoi180024r32","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1161\/ATVBAHA.116.308011","article-title":"Prevalence of elevated Lp(a) mass levels and patient thresholds in 532 359 patients in the United States.","volume":"36","author":"Varvel","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"hoi180024r33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S2213-8587(16)30042-0","article-title":"High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study.","volume":"4","author":"Langsted","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"hoi180024r34","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1373\/clinchem.2017.276931","article-title":"High lipoprotein(a) and low risk of major bleeding in brain and airways in the general population: a mendelian randomization study.","volume":"63","author":"Langsted","year":"2017","journal-title":"Clin Chem"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2685216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T19:35:09Z","timestamp":1571513709000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiology.jamanetwork.com\/article.aspx?doi=10.1001\/jamacardio.2018.1470"}},"subtitle":["A Mendelian Randomization Analysis"],"short-title":[],"issued":{"date-parts":[[2018,7,1]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2018.1470","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,1]]}}}