{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:04:40Z","timestamp":1790795080238,"version":"4.1.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1001\/jamacardio.2018.2112","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:31:31Z","timestamp":1532521891000},"page":"806","source":"Crossref","is-referenced-by-count":167,"title":["Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial"],"prefix":"10.1001","volume":"3","author":[{"given":"Stephen J.","family":"Nicholls","sequence":"first","affiliation":[{"name":"South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia"},{"name":"Department of Cardiovascular Medicine and Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Research, Baylor College of Medicine, Houston, Texas"},{"name":"Methodist DeBakey Heart and Vascular Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J. P.","family":"Kastelein","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Koenig","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Deutsches Zentrum f\u00fcr Herz-Kreislauf-Forschung E.V., partner site Munich Heart Alliance, Munich, Germany"},{"name":"Department of Internal Medicine, University of Ulm Medical Center, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Scott","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kallend","sequence":"additional","affiliation":[{"name":"The Medicines Company, Parsippany, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wijngaard","sequence":"additional","affiliation":[{"name":"The Medicines Company, Parsippany, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Borgman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Wolski","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"7","key":"hoi180033r1","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.jacc.2005.07.006","article-title":"The forgotten majority: unfinished business in cardiovascular risk reduction.","volume":"46","author":"Libby","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"hoi180033r2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1161\/01.CIR.79.1.8","article-title":"High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.","volume":"79","author":"Gordon","year":"1989","journal-title":"Circulation"},{"issue":"13","key":"hoi180033r3","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJMoa064278","article-title":"HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events.","volume":"357","author":"Barter","year":"2007","journal-title":"N Engl J Med"},{"issue":"11","key":"hoi180033r4","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1161\/01.ATV.0000184760.95957.d6","article-title":"Impact of short-term administration of high-density lipoproteins and atorvastatin on atherosclerosis in rabbits.","volume":"25","author":"Nicholls","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"hoi180033r5","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1172\/JCI114558","article-title":"Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.","volume":"85","author":"Badimon","year":"1990","journal-title":"J Clin Invest"},{"issue":"3","key":"hoi180033r6","first-page":"455","article-title":"High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits.","volume":"60","author":"Badimon","year":"1989","journal-title":"Lab Invest"},{"issue":"24","key":"hoi180033r7","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMoa1107579","article-title":"Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.","volume":"365","author":"Boden","year":"2011","journal-title":"N Engl J Med"},{"key":"hoi180033r8","doi-asserted-by":"publisher","first-page":"g4379","DOI":"10.1136\/bmj.g4379","article-title":"Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients.","volume":"349","author":"Keene","year":"2014","journal-title":"BMJ"},{"issue":"3","key":"hoi180033r9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.beem.2013.11.002","article-title":"Should low high-density lipoprotein cholesterol (HDL-C) be treated?","volume":"28","author":"Toth","year":"2014","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"hoi180033r10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1056\/NEJMoa1300955","article-title":"Effects of extended-release niacin with laropiprant in high-risk patients.","volume":"371","author":"Landray","year":"2014","journal-title":"N Engl J Med"},{"issue":"17","key":"hoi180033r11","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1056\/NEJMoa1001282","article-title":"Effects of combination lipid therapy in type 2 diabetes mellitus.","volume":"362","author":"Ginsberg","year":"2010","journal-title":"N Engl J Med"},{"issue":"9500","key":"hoi180033r12","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/S0140-6736(05)67667-2","article-title":"Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial.","volume":"366","author":"Keech","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"hoi180033r13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1567-5688(02)00047-8","article-title":"Reverse cholesterol transport in man: promotion of fecal steroid excretion by infusion of reconstituted HDL.","volume":"3","author":"Angelin","year":"2002","journal-title":"Atheroscler Suppl"},{"issue":"24","key":"hoi180033r14","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1161\/CIRCULATIONAHA.116.025687","article-title":"Safety and tolerability of CSL112, a reconstituted, infusible, plasma-derived apolipoprotein A-I, after acute myocardial infarction: the AEGIS-I trial (ApoA-I Event Reducing in Ischemic Syndromes I).","volume":"134","author":"Michael Gibson","year":"2016","journal-title":"Circulation"},{"issue":"12","key":"hoi180033r15","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1161\/01.CIR.0000013424.28206.8F","article-title":"High-density lipoprotein restores endothelial function in hypercholesterolemic men.","volume":"105","author":"Spieker","year":"2002","journal-title":"Circulation"},{"issue":"23","key":"hoi180033r16","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1161\/01.CIR.0000070934.69310.1A","article-title":"Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein.","volume":"107","author":"Bisoendial","year":"2003","journal-title":"Circulation"},{"issue":"17","key":"hoi180033r17","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1001\/jama.290.17.2292","article-title":"Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial.","volume":"290","author":"Nissen","year":"2003","journal-title":"JAMA"},{"issue":"4","key":"hoi180033r18","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/ATVBAHA.115.307052","article-title":"High-density lipoprotein subfractions and cholesterol efflux capacities after infusion of MDCO-216 (apolipoprotein a-imilano\/palmitoyl-oleoyl-phosphatidylcholine) in healthy volunteers and stable coronary artery disease patients.","volume":"36","author":"Kempen","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"hoi180033r19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/ehjcvp\/pvv041","article-title":"A single infusion of MDCO-216 (ApoA-1 Milano\/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease.","volume":"2","author":"Kallend","year":"2016","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"4","key":"hoi180033r20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10557-017-6746-x","article-title":"MDCO-216 does not induce adverse immunostimulation, in contrast to its predecessor ETC-216.","volume":"31","author":"Reijers","year":"2017","journal-title":"Cardiovasc Drugs Ther"},{"issue":"9","key":"hoi180033r21","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1001\/jama.291.9.1071","article-title":"Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial.","volume":"291","author":"Nissen","year":"2004","journal-title":"JAMA"},{"issue":"13","key":"hoi180033r22","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1001\/jama.295.13.jpc60002","article-title":"Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.","volume":"295","author":"Nissen","year":"2006","journal-title":"JAMA"},{"issue":"13","key":"hoi180033r23","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1001\/jama.299.13.1561","article-title":"Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial.","volume":"299","author":"Nissen","year":"2008","journal-title":"JAMA"},{"issue":"13","key":"hoi180033r24","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1001\/jama.299.13.1547","article-title":"Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial.","volume":"299","author":"Nissen","year":"2008","journal-title":"JAMA"},{"issue":"13","key":"hoi180033r25","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1056\/NEJMoa070635","article-title":"Effect of torcetrapib on the progression of coronary atherosclerosis.","volume":"356","author":"Nissen","year":"2007","journal-title":"N Engl J Med"},{"issue":"12","key":"hoi180033r26","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJMoa054699","article-title":"Effect of ACAT inhibition on the progression of coronary atherosclerosis.","volume":"354","author":"Nissen","year":"2006","journal-title":"N Engl J Med"},{"issue":"18","key":"hoi180033r27","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1001\/jama.292.18.2217","article-title":"Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial.","volume":"292","author":"Nissen","year":"2004","journal-title":"JAMA"},{"issue":"22","key":"hoi180033r28","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","article-title":"Effect of two intensive statin regimens on progression of coronary disease.","volume":"365","author":"Nicholls","year":"2011","journal-title":"N Engl J Med"},{"issue":"22","key":"hoi180033r29","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1001\/jama.2016.16951","article-title":"Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial.","volume":"316","author":"Nicholls","year":"2016","journal-title":"JAMA"},{"issue":"13","key":"hoi180033r30","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1056\/NEJMoa1706444","article-title":"Effects of anacetrapib in patients with atherosclerotic vascular disease.","volume":"377","author":"Bowman","year":"2017","journal-title":"N Engl J Med"},{"issue":"2","key":"hoi180033r31","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.","volume":"364","author":"Khera","year":"2011","journal-title":"N Engl J Med"},{"issue":"20","key":"hoi180033r32","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1161\/hc4501.098952","article-title":"Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content.","volume":"104","author":"Rong","year":"2001","journal-title":"Circulation"},{"issue":"17","key":"hoi180033r33","doi-asserted-by":"publisher","first-page":"7166","DOI":"10.1073\/pnas.1016086108","article-title":"HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells.","volume":"108","author":"Feig","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"hoi180033r34","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1016\/j.jacc.2010.02.026","article-title":"Intravascular ultrasound-derived measures of coronary atherosclerotic plaque burden and clinical outcome.","volume":"55","author":"Nicholls","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"hoi180033r35","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease.","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2689022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:12:22Z","timestamp":1537359142000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiology.jamanetwork.com\/article.aspx?doi=10.1001\/jamacardio.2018.2112"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2018.2112","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}