{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:19:51Z","timestamp":1790428791804,"version":"4.1.0"},"reference-count":6,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1001\/jamacardio.2019.1189","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T11:08:12Z","timestamp":1557313692000},"page":"596","source":"Crossref","is-referenced-by-count":94,"title":["Antibacterial Activity of Ticagrelor in Conventional Antiplatelet Dosages Against Antibiotic-Resistant Gram-Positive Bacteria"],"prefix":"10.1001","volume":"4","author":[{"given":"Patrizio","family":"Lancellotti","sequence":"first","affiliation":[{"name":"Laboratory of Cardiology, GIGA Cardiovascular Sciences, University of Li\u00e8ge Hospital, Department of Cardiology, CHU Sart Tilman, Li\u00e8ge, Belgium"},{"name":"Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiology, GIGA Cardiovascular Sciences, University of Li\u00e8ge Hospital, Department of Cardiology, CHU Sart Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Jacques","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiology, GIGA Cardiovascular Sciences, University of Li\u00e8ge Hospital, Department of Cardiology, CHU Sart Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Servais","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiology, GIGA Cardiovascular Sciences, University of Li\u00e8ge Hospital, Department of Cardiology, CHU Sart Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Goffin","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiology, GIGA Cardiovascular Sciences, University of Li\u00e8ge Hospital, Department of Cardiology, CHU Sart Tilman, Li\u00e8ge, Belgium"},{"name":"Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Li\u00e8ge, CHU Sart Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Pirotte","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Li\u00e8ge, CHU Sart Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Oury","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiology, GIGA Cardiovascular Sciences, University of Li\u00e8ge Hospital, Department of Cardiology, CHU Sart Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"21","key":"hld190001r1","doi-asserted-by":"publisher","first-page":"6013","DOI":"10.1016\/j.bmcl.2007.07.057","article-title":"From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.","volume":"17","author":"Springthorpe","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"11","key":"hld190001r2","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Ticagrelor versus clopidogrel in patients with acute coronary syndromes.","volume":"361","author":"Wallentin","year":"2009","journal-title":"N Engl J Med"},{"issue":"7","key":"hld190001r3","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3109\/09537104.2013.842965","article-title":"Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared to clopidogrel in the PLATO study.","volume":"25","author":"Storey","year":"2014","journal-title":"Platelets"},{"issue":"4","key":"hld190001r4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jacbts.2018.05.005","article-title":"Ticagrelor reduces thromboinflammatory markers in patients with pneumonia.","volume":"3","author":"Sexton","year":"2018","journal-title":"JACC Basic Transl Sci"},{"issue":"9","key":"hld190001r5","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1124\/dmd.110.032250","article-title":"Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects.","volume":"38","author":"Teng","year":"2010","journal-title":"Drug Metab Dispos"},{"issue":"25","key":"hld190001r6","doi-asserted-by":"publisher","first-page":"e1159","DOI":"10.1161\/CIR.0000000000000503","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"135","author":"Nishimura","year":"2017","journal-title":"Circulation"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamacardiology\/article-pdf\/4\/6\/596\/17664487\/jamacardiology_lancellotti_2019_ld_190001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T11:01:12Z","timestamp":1560942072000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiology.jamanetwork.com\/article.aspx?doi=10.1001\/jamacardio.2019.1189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2019.1189","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,1]]}}}