{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:23:45Z","timestamp":1792844625767,"version":"4.5.0"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1001\/jamacardio.2019.1581","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T15:33:33Z","timestamp":1559144013000},"page":"620","source":"Crossref","is-referenced-by-count":55,"title":["Genetic Variation in <i>LPA<\/i>, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification"],"prefix":"10.1001","volume":"4","author":[{"given":"Nicolas","family":"Perrot","sequence":"first","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Th\u00e9riault","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dina","sequence":"additional","affiliation":[{"name":"L'Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre National de la Recherche Scientifique, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"McGill University Health Center Research Institute, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Matthijs","family":"Boekholdt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidwell","family":"Rigade","sequence":"additional","affiliation":[{"name":"L'Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre National de la Recherche Scientifique, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey-Anne","family":"Despr\u00e9s","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Poulin","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Capoulade","sequence":"additional","affiliation":[{"name":"L'Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre National de la Recherche Scientifique, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Le Tourneau","sequence":"additional","affiliation":[{"name":"L'Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre National de la Recherche Scientifique, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Messika-Zeitoun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Assistance Publique\u2013H\u00f4pitaux de Paris, Bichat Hospital, Paris, France"},{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika\u00ebl","family":"Trottier","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Tessier","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Guimond","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Engert","sequence":"additional","affiliation":[{"name":"McGill University Health Center Research Institute, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Tee","family":"Khaw","sequence":"additional","affiliation":[{"name":"Medical Research Council Epidemiology Unit, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Wareham","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Surgery, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Schott","sequence":"additional","affiliation":[{"name":"L'Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre National de la Recherche Scientifique, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Thanassoulis","sequence":"additional","affiliation":[{"name":"McGill University Health Center Research Institute, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit J.","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"6","key":"hoi190026r1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.jacc.2016.11.042","article-title":"A test in context: Lipoprotein(a), diagnosis, prognosis, controversies, and emerging therapies.","volume":"69","author":"Tsimikas","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"hoi190026r2","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1194\/jlr.M040733","article-title":"Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a).","volume":"54","author":"Leibundgut","year":"2013","journal-title":"J Lipid Res"},{"issue":"1","key":"hoi190026r3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1365-2796.2012.02592.x","article-title":"Lipoprotein(a): resurrected by genetics.","volume":"273","author":"Kronenberg","year":"2013","journal-title":"J Intern Med"},{"issue":"7","key":"hoi190026r4","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1161\/ATVBAHA.115.305306","article-title":"Heritability of biomarkers of oxidized lipoproteins: twin pair study.","volume":"35","author":"Rao","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"26","key":"hoi190026r5","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1056\/NEJMoa0902604","article-title":"Genetic variants associated with Lp(a) lipoprotein level and coronary disease.","volume":"361","author":"Clarke","year":"2009","journal-title":"N Engl J Med"},{"issue":"3","key":"hoi190026r6","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/ng.314","article-title":"Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.","volume":"41","author":"Tr\u00e9gou\u00ebt","year":"2009","journal-title":"Nat Genet"},{"issue":"4","key":"hoi190026r7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","volume":"43","author":"Schunkert","year":"2011","journal-title":"Nat Genet"},{"issue":"25","key":"hoi190026r8","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1016\/j.jacc.2016.10.033","article-title":"Phenotypic characterization of genetically lowered human Lipoprotein(a) levels.","volume":"68","author":"Emdin","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"hoi190026r9","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1038\/s41467-018-04668-w","article-title":"Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.","volume":"9","author":"Zekavat","year":"2018","journal-title":"Nat Commun"},{"issue":"6","key":"hoi190026r10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa1109034","article-title":"Genetic associations with valvular calcification and aortic stenosis.","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N Engl J Med"},{"issue":"5","key":"hoi190026r11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"hoi190026r12","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1161\/CIRCGENETICS.113.000400","article-title":"Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective mendelian randomization study and replication in a case-control cohort.","volume":"7","author":"Arsenault","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"issue":"1","key":"hoi190026r13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1001\/jamacardio.2017.4266","article-title":"Association of LPA variants with aortic stenosis: a large-scale study using diagnostic and procedural codes from electronic health records.","volume":"3","author":"Chen","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"11","key":"hoi190026r14","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.jacc.2015.07.020","article-title":"Oxidized phospholipids, lipoprotein(a), and progression of calcific aortic valve stenosis.","volume":"66","author":"Capoulade","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"13","key":"hoi190026r15","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1056\/NEJMe0807001","article-title":"Calcific aortic stenosis\u2014time to look more closely at the valve.","volume":"359","author":"Otto","year":"2008","journal-title":"N Engl J Med"},{"key":"hoi190026r16","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ijcard.2018.07.107","article-title":"Life\u2019s simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.","volume":"269","author":"Perrot","year":"2018","journal-title":"Int J Cardiol"},{"issue":"14","key":"hoi190026r18","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.jacc.2007.12.031","article-title":"Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis.","volume":"51","author":"Boss\u00e9","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"hoi190026r19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/CIRCULATIONAHA.111.073452","article-title":"Look more closely at the valve: imaging calcific aortic valve disease.","volume":"125","author":"Aikawa","year":"2012","journal-title":"Circulation"},{"issue":"6","key":"hoi190026r20","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1161\/CIRCULATIONAHA.105.569467","article-title":"Familial aggregation of calcific aortic valve stenosis in the western part of France.","volume":"113","author":"Probst","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"hoi190026r21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1136\/hrt.2004.037093","article-title":"Heterogeneous geographic distribution of patients with aortic valve stenosis: arguments for new aetiological hypothesis.","volume":"91","author":"Le Gal","year":"2005","journal-title":"Heart"},{"issue":"6","key":"hoi190026r22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1161\/CIRCGENETICS.117.001742","article-title":"Familial aggregation of aortic valvular stenosis: a nationwide study of sibling risk.","volume":"10","author":"Martinsson","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"issue":"3","key":"hoi190026r23","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jacl.2018.02.007","article-title":"Elevated lipoprotein(a) levels are associated with coronary artery calcium scores in asymptomatic individuals with a family history of premature atherosclerotic cardiovascular disease.","volume":"12","author":"Verweij","year":"2018","journal-title":"J Clin Lipidol"},{"issue":"2","key":"hoi190026r24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jacc.2017.11.014","article-title":"NHLBI working group recommendations to reduce lipoprotein(a)-mediated risk of cardiovascular disease and aortic stenosis.","volume":"71","author":"Tsimikas","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"hoi190026r25","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/joim.2015.278.issue-2","article-title":"Lipoprotein(a) levels are associated with aortic valve calcification in asymptomatic patients with familial hypercholesterolaemia.","volume":"278","author":"Vongpromek","year":"2015","journal-title":"J Intern Med"},{"key":"hoi190026r26","first-page":"6","article-title":"Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography.","volume":"7495","author":"Agnese","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"hoi190026r27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.111.051052","article-title":"Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis.","volume":"125","author":"Dweck","year":"2012","journal-title":"Circulation"},{"issue":"21","key":"hoi190026r28","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1093\/eurheartj\/eht034","article-title":"Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?","volume":"34","author":"Dweck","year":"2013","journal-title":"Eur Heart J"},{"issue":"25","key":"hoi190026r29","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1016\/j.jacc.2010.12.046","article-title":"Imaging of the aortic valve using fluorodeoxyglucose positron emission tomography increased valvular fluorodeoxyglucose uptake in aortic stenosis.","volume":"57","author":"Marincheva-Savcheva","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"hoi190026r30","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.amjcard.2011.11.060","article-title":"Detection of 18fluoride sodium accumulation by positron emission tomography in calcified stenotic aortic valves.","volume":"109","author":"Hyafil","year":"2012","journal-title":"Am J Cardiol"},{"issue":"23","key":"hoi190026r31","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1093\/eurheartj\/ehq386","article-title":"Lipoprotein(a) as a cardiovascular risk factor: current status.","volume":"31","author":"Nordestgaard","year":"2010","journal-title":"Eur Heart J"},{"issue":"10057","key":"hoi190026r32","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/S0140-6736(16)31009-1","article-title":"Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.","volume":"388","author":"Viney","year":"2016","journal-title":"Lancet"},{"key":"hoi190026r17","unstructured":"ChangC. Plink2.0. https:\/\/www.cog-genomics.org\/plink\/2.0\/. Published April 29, 2019. Accessed May 1, 2019."}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamacardiology\/article-pdf\/4\/7\/620\/17729270\/jamacardiology_perrot_2019_oi_190026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T15:02:58Z","timestamp":1563375778000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiology.jamanetwork.com\/article.aspx?doi=10.1001\/jamacardio.2019.1581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2019.1581","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,1]]}}}