{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:41:27Z","timestamp":1789213287552,"version":"build-2803163510"},"reference-count":41,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2020,7,1]]},"DOI":"10.1001\/jamacardio.2020.0799","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T13:00:18Z","timestamp":1586955618000},"page":"795","source":"Crossref","is-referenced-by-count":53,"title":["Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life"],"prefix":"10.1001","volume":"5","author":[{"given":"Chike C.","family":"Nwabuo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique T.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duke","family":"Appiah","sequence":"additional","affiliation":[{"name":"Department of Public Health, Texas Tech University Health Sciences Center, Lubbock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique D.","family":"Vasconcellos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queen N.","family":"Aghaji","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Viera","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal S.","family":"Rana","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California, Division of Research, Oakland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi V.","family":"Shah","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh L.","family":"Murthy","sequence":"additional","affiliation":[{"name":"Frankel Cardiovascular Center, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norrina B.","family":"Allen","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Schreiner","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Public Health, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd-Jones","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"hoi200021r1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-025322","article-title":"Number of blood pressure measurements needed to estimate long-term visit-to-visit systolic blood pressure variability for predicting cardiovascular risk: a 10-year retrospective cohort study in a primary care clinic in Malaysia.","volume":"9","author":"Lim","year":"2019","journal-title":"BMJ Open"},{"key":"hoi200021r2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ijcard.2019.06.035","article-title":"Visit-to-visit variability of metabolic parameters and risk of heart failure: a nationwide population-based study.","volume":"293","author":"Kwon","year":"2019","journal-title":"Int J Cardiol"},{"issue":"5","key":"hoi200021r3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.7326\/M14-2803","article-title":"Visit-to-visit variability of blood pressure and coronary heart disease, stroke, heart failure, and mortality: a cohort study.","volume":"163","author":"Muntner","year":"2015","journal-title":"Ann Intern Med"},{"issue":"5","key":"hoi200021r4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/ehjci\/jey123","article-title":"Left ventricular global function index predicts incident heart failure and cardiovascular disease in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study.","volume":"20","author":"Nwabuo","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"11","key":"hoi200021r5","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects.","volume":"41","author":"Friedman","year":"1988","journal-title":"J Clin Epidemiol"},{"issue":"6","key":"hoi200021r6","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/HYPERTENSIONAHA.117.10144","article-title":"Visit-to-visit blood pressure variability in young adulthood and hippocampal volume and integrity at middle age: the CARDIA study (Coronary Artery Risk Development in Young Adults).","volume":"70","author":"Yano","year":"2017","journal-title":"Hypertension"},{"issue":"9718","key":"hoi200021r7","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0140-6736(10)60309-1","article-title":"Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension.","volume":"375","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"issue":"2","key":"hoi200021r8","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/ajh\/hpw124","article-title":"Visit-to-visit blood pressure variability\u2014what is the current challenge?","volume":"30","author":"Yano","year":"2017","journal-title":"Am J Hypertens"},{"issue":"12","key":"hoi200021r9","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.echo.2017.08.001","article-title":"Association of aortic root dilation from early adulthood to middle age with cardiac structure and function: the CARDIA study.","volume":"30","author":"Nwabuo","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"issue":"9","key":"hoi200021r10","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1093\/ehjci\/jey086","article-title":"Cumulative blood pressure from early adulthood to middle age is associated with left atrial remodelling and subclinical dysfunction assessed by three-dimensional echocardiography: a prospective post hoc analysis from the coronary artery risk development in young adults study.","volume":"19","author":"Vasconcellos","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"8","key":"hoi200021r11","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/echo.2015.32.issue-8","article-title":"Quality control and reproducibility in M-Mode, two-dimensional, and speckle tracking echocardiography acquisition and analysis: the CARDIA study, year 25 examination experience.","volume":"32","author":"Armstrong","year":"2015","journal-title":"Echocardiography"},{"issue":"7","key":"hoi200021r12","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.echo.2017.03.010","article-title":"Reference ranges and regional patterns of left ventricular strain and strain rate using two-dimensional speckle-tracking echocardiography in a healthy middle-aged black and white population: the CARDIA study.","volume":"30","author":"Moreira","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"issue":"1","key":"hoi200021r13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"12","key":"hoi200021r14","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/ejhf.2014.16.issue-12","article-title":"Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community-based cohort.","volume":"16","author":"Russo","year":"2014","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"hoi200021r15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ijcard.2014.01.003","article-title":"Framingham score and LV mass predict events in young adults: CARDIA study.","volume":"172","author":"Armstrong","year":"2014","journal-title":"Int J Cardiol"},{"issue":"23","key":"hoi200021r16","first-page":"5451","article-title":"Relationship between blood pressure variability and target organ damage in elderly patients.","volume":"21","author":"Li","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"hoi200021r17","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/1471-2261-14-188","article-title":"Visit-to-visit blood pressure variability is a marker of cardiac diastolic function and carotid atherosclerosis.","volume":"14","author":"Okada","year":"2014","journal-title":"BMC Cardiovasc Disord"},{"issue":"8","key":"hoi200021r18","doi-asserted-by":"publisher","first-page":"427","DOI":"10.11622\/smedj.2019030","article-title":"Relation of blood pressure variability to left ventricular function and arterial stiffness in hypertensive patients.","volume":"60","author":"Shin","year":"2019","journal-title":"Singapore Med J"},{"issue":"2 Pt 2","key":"hoi200021r19","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1161\/hy0202.104376","article-title":"Blood pressure variability and organ damage in a general population: results from the PAMELA study (Pressioni Arteriose Monitorate E Loro Associazioni).","volume":"39","author":"Sega","year":"2002","journal-title":"Hypertension"},{"issue":"10","key":"hoi200021r20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002071","article-title":"Distinct aspects of left ventricular mechanical function are differentially associated with cardiovascular outcomes and all-cause mortality in the community.","volume":"4","author":"Cheng","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"hoi200021r21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005521","article-title":"Global longitudinal strain by echocardiography predicts long-term risk of cardiovascular morbidity and mortality in a low-risk general population: the Copenhagen City Heart study.","volume":"10","author":"Biering-S\u00f8rensen","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"hoi200021r22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.amjcard.2013.09.028","article-title":"Left ventricular hypertrophy patterns and incidence of heart failure with preserved versus reduced ejection fraction.","volume":"113","author":"Velagaleti","year":"2014","journal-title":"Am J Cardiol"},{"issue":"23","key":"hoi200021r23","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1161\/CIRCULATIONAHA.112.112201","article-title":"Prognosis of individuals with asymptomatic left ventricular systolic dysfunction in the Multi-Ethnic Study of Atherosclerosis (MESA).","volume":"126","author":"Yeboah","year":"2012","journal-title":"Circulation"},{"issue":"25","key":"hoi200021r24","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1016\/j.jacc.2008.09.014","article-title":"The relationship of left ventricular mass and geometry to incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis) study.","volume":"52","author":"Bluemke","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"hoi200021r25","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1093\/ehjci\/jeu018","article-title":"Left atrial dimension and traditional cardiovascular risk factors predict 20-year clinical cardiovascular events in young healthy adults: the CARDIA study.","volume":"15","author":"Armstrong","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"hoi200021r26","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5126270","article-title":"Impaired glucose metabolism is associated with visit-to-visit blood pressure variability in participants without cardiovascular disease.","volume":"2018","author":"Sasaki","year":"2018","journal-title":"Int J Hypertens"},{"issue":"4","key":"hoi200021r27","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1097\/HJH.0b013e32835e2a4a","article-title":"Genetic and environmental influences on blood pressure variability: a study in twins.","volume":"31","author":"Xu","year":"2013","journal-title":"J Hypertens"},{"issue":"12","key":"hoi200021r28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11892-018-1108-z","article-title":"Blood pressure variability and autonomic dysfunction.","volume":"18","author":"Spallone","year":"2018","journal-title":"Curr Diab Rep"},{"issue":"1","key":"hoi200021r29","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1186\/s12889-018-6083-4","article-title":"Impact of body mass index on long-term blood pressure variability: a cross-sectional study in a cohort of Chinese adults.","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Public Health"},{"issue":"12","key":"hoi200021r30","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1291\/hypres.26.991","article-title":"Reduced endothelial vasomotor function and enhanced neointimal formation after vascular injury in a rat model of blood pressure lability.","volume":"26","author":"Eto","year":"2003","journal-title":"Hypertens Res"},{"issue":"5","key":"hoi200021r31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1001\/jamacardio.2019.0751","article-title":"Visit-to-visit blood pressure variability, coronary atheroma progression, and clinical outcomes.","volume":"4","author":"Clark","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"4","key":"hoi200021r32","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1161\/HYPERTENSIONAHA.118.11325","article-title":"Blood pressure variability, arterial stiffness, and arterial remodeling.","volume":"72","author":"Zhou","year":"2018","journal-title":"Hypertension"},{"issue":"6","key":"hoi200021r33","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2174\/1381612825666190329122024","article-title":"Visit-to-visit blood pressure variability and arterial stiffness: which came first: the chicken or the egg?","volume":"25","author":"Miyauchi","year":"2019","journal-title":"Curr Pharm Des"},{"issue":"7","key":"hoi200021r34","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/ajh\/hpt040","article-title":"Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA).","volume":"26","author":"Shimbo","year":"2013","journal-title":"Am J Hypertens"},{"issue":"3","key":"hoi200021r35","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/HJH.0000000000001192","article-title":"Aortic stiffness and blood pressure variability in young people: a multimodality investigation of central and peripheral vasculature.","volume":"35","author":"Boardman","year":"2017","journal-title":"J Hypertens"},{"key":"hoi200021r36","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.vph.2016.05.007","article-title":"Blood pressure variability provokes vascular \u00df-adrenoceptor desensitization in rats.","volume":"82","author":"Rocha","year":"2016","journal-title":"Vascul Pharmacol"},{"issue":"9","key":"hoi200021r37","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1253\/circj.CJ-14-0027","article-title":"Large blood pressure variability aggravates arteriolosclerosis and cortical sclerotic changes in the kidney in hypertensive rats.","volume":"78","author":"Aoki","year":"2014","journal-title":"Circ J"},{"issue":"12","key":"hoi200021r38","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1161\/CIRCULATIONAHA.113.002717","article-title":"Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial.","volume":"128","author":"Hata","year":"2013","journal-title":"Circulation"},{"issue":"7","key":"hoi200021r39","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.115.004426","article-title":"Association of aortic stiffness with left ventricular remodeling and reduced left ventricular function measured by magnetic resonance imaging: the Multi-Ethnic Study of Atherosclerosis.","volume":"9","author":"Ohyama","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"hoi200021r40","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004903","article-title":"Relations between aortic stiffness and left ventricular mechanical function in the community.","volume":"6","author":"Bell","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"hoi200021r41","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1253\/circj.CJ-12-1253","article-title":"Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats.","volume":"77","author":"Yasuoka","year":"2013","journal-title":"Circ J"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2764758\/jamacardiology_nwabuo_2020_oi_200021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T11:03:57Z","timestamp":1594811037000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2764758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2020.0799","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737755191.793577725","asserted-by":"object"}]},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}