{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:11:08Z","timestamp":1790244668819,"version":"4.1.0"},"reference-count":26,"publisher":"American Medical Association (AMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"DOI":"10.1001\/jamacardio.2020.4390","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T17:05:22Z","timestamp":1601485522000},"source":"Crossref","is-referenced-by-count":46,"title":["Rivaroxaban and Aspirin in Patients With Symptomatic Lower Extremity Peripheral Artery Disease"],"prefix":"10.1001","author":[{"given":"Eric","family":"Kaplovitch","sequence":"first","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada"},{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Dyal","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Aboyans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dupuytren University Hospital, Limoges, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1094, Limoges University, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Abola","sequence":"additional","affiliation":[{"name":"College of Medicine, University of the Philippines\/Philippine Heart Center, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Verhamme","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Avezum","sequence":"additional","affiliation":[{"name":"International Research Center, Hospital Alem\u00e3o Oswaldo Cruz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A. A.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Clinical Development, Thrombosis & Vascular Medicine, Bayer US LLC, Whippany, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada"},{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada"},{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S.","family":"Anand","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada"},{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"issue":"25","key":"hoi200066r1","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1161\/CIRCULATIONAHA.117.024469","article-title":"A structured review of antithrombotic therapy in peripheral artery disease with a focus on revascularization: a TASC (InterSociety Consensus for the Management of Peripheral Artery Disease) initiative.","volume":"135","author":"Hess","year":"2017","journal-title":"Circulation"},{"issue":"14","key":"hoi200066r2","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1056\/NEJMoa1709118","article-title":"Rivaroxaban with or without aspirin in stable cardiovascular disease.","volume":"377","author":"Eikelboom","year":"2017","journal-title":"N Engl J Med"},{"issue":"25","key":"hoi200066r3","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1016\/j.jacc.2019.02.079","article-title":"Rivaroxaban plus aspirin versus aspirin in relation to vascular risk in the COMPASS trial.","volume":"73","author":"Anand","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"10117","key":"hoi200066r4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0140-6736(17)32409-1","article-title":"Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.","volume":"391","author":"Anand","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"hoi200066r5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1161\/CIRCULATIONAHA.116.025880","article-title":"Ticagrelor compared with clopidogrel in patients with prior lower extremity revascularization for peripheral artery disease.","volume":"135","author":"Jones","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"hoi200066r6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000697","article-title":"Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease.","volume":"3","author":"Armstrong","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"hoi200066r7","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1161\/CIRCULATIONAHA.115.019355","article-title":"Acute limb ischemia and outcomes with vorapaxar in patients with peripheral artery disease: results from the trial to assess the effects of vorapaxar in preventing heart attack and stroke in patients with atherosclerosis-thrombolysis in myocardial infarction 50 (TRA2\u00b0P-TIMI 50).","volume":"133","author":"Bonaca","year":"2016","journal-title":"Circulation"},{"issue":"8","key":"hoi200066r8","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.cjca.2017.06.001","article-title":"Rationale, design and baseline characteristics of participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial.","volume":"33","author":"Bosch","year":"2017","journal-title":"Can J Cardiol"},{"issue":"10117","key":"hoi200066r9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0140-6736(17)32458-3","article-title":"Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial.","volume":"391","author":"Connolly","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"hoi200066r10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1177\/1740774510396933","article-title":"Bayesian models for subgroup analysis in clinical trials.","volume":"8","author":"Jones","year":"2011","journal-title":"Clin Trials"},{"issue":"16","key":"hoi200066r13","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.jacc.2007.11.077","article-title":"Long-term prognosis of patients with peripheral arterial disease: a comparison in patients with coronary artery disease.","volume":"51","author":"Welten","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"hoi200066r14","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease.","volume":"116","author":"Criqui","year":"2015","journal-title":"Circ Res"},{"issue":"3","key":"hoi200066r15","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jacc.2017.11.021","article-title":"Antithrombotic therapy in peripheral artery disease: generating and translating evidence into practice.","volume":"71","author":"Jones","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"hoi200066r16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.7326\/0003-4819-151-5-200909010-00003","article-title":"The net clinical benefit of warfarin anticoagulation in atrial fibrillation.","volume":"151","author":"Singer","year":"2009","journal-title":"Ann Intern Med"},{"issue":"9901","key":"hoi200066r17","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis.","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"issue":"9","key":"hoi200066r18","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","article-title":"2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries endorsed by the European Stroke Organization (ESO), the Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC), and the European Society for Vascular Surgery (ESVS).","volume":"39","author":"Aboyans","year":"2018","journal-title":"Eur Heart J"},{"issue":"11","key":"hoi200066r19","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1016\/j.jacc.2016.11.007","article-title":"2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"69","author":"Gerhard-Herman","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"1S","key":"hoi200066r20","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia.","volume":"58","author":"Conte","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"3","key":"hoi200066r21","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes.","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur Heart J."},{"issue":"9453","key":"hoi200066r22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0140-6736(04)17670-8","article-title":"External validity of randomised controlled trials: \u201cto whom do the results of this trial apply?\u201d.","volume":"365","author":"Rothwell","year":"2005","journal-title":"Lancet"},{"issue":"21","key":"hoi200066r23","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1056\/NEJMoa2000052","article-title":"Rivaroxaban in peripheral artery disease after revascularization.","volume":"382","author":"Bonaca","year":"2020","journal-title":"N Engl J Med"},{"issue":"3","key":"hoi200066r24","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1177\/2047487319882154","article-title":"Risk factors and clinical outcomes in chronic coronary and peripheral artery disease: an analysis of the randomized, double-blind COMPASS trial.","volume":"27","author":"Vanassche","year":"2020","journal-title":"Eur J Prev Cardiol"},{"issue":"9","key":"hoi200066r25","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1093\/eurheartj\/ehx658","article-title":"External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry.","volume":"39","author":"Darmon","year":"2018","journal-title":"Eur Heart J"},{"issue":"1","key":"hoi200066r26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1161\/CIRCULATIONAHA.120.046048","article-title":"The COMPASS trial: net clinical benefit of low-dose rivaroxaban plus aspirin as compared with aspirin in patients with chronic vascular disease.","volume":"142","author":"Steffel","year":"2020","journal-title":"Circulation"},{"key":"hoi200066r11","volume-title":"Bayesian Approaches to Clinical Trials and Health-Care Evaluation.","author":"Spiegelhalter","year":"2004"},{"key":"hoi200066r12","unstructured":"Pennello? G. Bayesian hierarchical models for subgroup analysis in clinical studies: Biopharmaceutical Applied Statistics Symposium (BASS) program. Published 2013. Accessed August 20, 2020.? http:\/\/www.bassconference.org\/tutorials\/BASS%202013%20Pennello.pdf"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2771002\/jamacardiology_kaplovitch_2020_oi_200066_1606327014.71564.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T14:36:14Z","timestamp":1606919774000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2771002"}},"subtitle":["A Subanalysis of the COMPASS Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2020.4390","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}