{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:23:48Z","timestamp":1792686228857,"version":"4.5.0"},"reference-count":19,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2022,6,1]]},"DOI":"10.1001\/jamacardio.2022.0480","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T15:06:05Z","timestamp":1649862365000},"page":"583","source":"Crossref","is-referenced-by-count":15,"title":["Effect of 15-mg Edoxaban on Clinical Outcomes in 3 Age Strata in Older Patients With Atrial Fibrillation"],"prefix":"10.1001","volume":"7","author":[{"given":"Masaru","family":"Kuroda","sequence":"first","affiliation":[{"name":"Department of Cardiology, Akashi Medical Center, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Tamiya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koto Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Nose","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nose Hospital, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Ogimoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Uwajima City Hospital, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Taura","sequence":"additional","affiliation":[{"name":"Clinical Development Department III, Development Function, Research and Development Division, Daiichi Sankyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Clinical Development Department III, Development Function, Research and Development Division, Daiichi Sankyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Clinical Development Department III, Development Function, Research and Development Division, Daiichi Sankyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"The Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division, Daiichi Sankyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Akao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"The Cardiovascular Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"The Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Okumura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"18","key":"hoi220010r1","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) study.","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"issue":"8","key":"hoi220010r2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"issue":"1","key":"hoi220010r3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jacc.2019.01.011","article-title":"2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society.","volume":"74","author":"January","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"38","key":"hoi220010r4","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS.","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur Heart J"},{"issue":"9","key":"hoi220010r5","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1253\/circj.CJ-14-0344","article-title":"Inappropriate use of oral anticoagulants for patients with atrial fibrillation.","volume":"78","author":"Akao","year":"2014","journal-title":"Circ J"},{"issue":"9921","key":"hoi220010r6","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials.","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"hoi220010r7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.arr.2018.10.006","article-title":"Overview of oral antithrombotic treatment in elderly patients with atrial fibrillation.","volume":"49","author":"Kato","year":"2019","journal-title":"Ageing Res Rev"},{"issue":"18","key":"hoi220010r8","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1056\/NEJMoa2012883","article-title":"Low-dose edoxaban in very elderly patients with atrial fibrillation.","volume":"383","author":"Okumura","year":"2020","journal-title":"N Engl J Med"},{"key":"hoi220010r9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ahj.2017.08.017","article-title":"Edoxaban for the management of elderly Japanese patients with atrial fibrillation ineligible for standard oral anticoagulant therapies: rationale and design of the ELDERCARE-AF study.","volume":"194","author":"Okumura","year":"2017","journal-title":"Am Heart J"},{"issue":"9","key":"hoi220010r12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008462","article-title":"Impact of physical frailty on disability in community-dwelling older adults: a prospective cohort study.","volume":"5","author":"Makizako","year":"2015","journal-title":"BMJ Open"},{"issue":"2","key":"hoi220010r13","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1161\/CIRCEP.113.000858","article-title":"Net clinical benefit of warfarin therapy in elderly Chinese patients with atrial fibrillation.","volume":"7","author":"Siu","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"5","key":"hoi220010r14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003432","article-title":"Efficacy and safety of edoxaban in elderly patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial.","volume":"5","author":"Kato","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"13","key":"hoi220010r15","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1136\/heartjnl-2016-310358","article-title":"Effects of dabigatran according to age in atrial fibrillation.","volume":"103","author":"Lauw","year":"2017","journal-title":"Heart"},{"issue":"28","key":"hoi220010r16","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1093\/eurheartj\/ehu046","article-title":"Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial.","volume":"35","author":"Halvorsen","year":"2014","journal-title":"Eur Heart J"},{"issue":"2","key":"hoi220010r17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1378\/chest.15-1095","article-title":"Clinical characteristics and outcomes in extreme elderly (age =85 years) Japanese patients with atrial fibrillation: the Fushimi AF Registry.","volume":"149","author":"Yamashita","year":"2016","journal-title":"Chest"},{"issue":"1","key":"hoi220010r18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1161\/CIRCULATIONAHA.117.031658","article-title":"Oral anticoagulation in very elderly patients with atrial fibrillation: a nationwide cohort study.","volume":"138","author":"Chao","year":"2018","journal-title":"Circulation"},{"issue":"2","key":"hoi220010r19","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.113.005008","article-title":"Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).","volume":"130","author":"Halperin","year":"2014","journal-title":"Circulation"},{"key":"hoi220010r10","unstructured":"Study of DU-176b aged 80 years or older. ClinicalTrials.gov Identifier: NCT02801669. Updated November 19, 2020. Accessed March 14, 2022. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02801669"},{"key":"hoi220010r11","unstructured":"National Longevity Medical Research Center. Research funding for longevity sciences from the National Center for Geriatrics and Gerontology, general report 2014. Accessed May 14, 2021. https:\/\/www.ncgg.go.jp\/ncgg-kenkyu\/kadai26.html"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2790738\/jamacardiology_kuroda_2022_oi_220010_1654532435.27494.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T15:07:29Z","timestamp":1654700849000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2790738"}},"subtitle":["A Prespecified Subanalysis of the ELDERCARE\u2013AF Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2022.0480","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}