{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:38:45Z","timestamp":1793054325881,"version":"4.5.0"},"reference-count":28,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"\n Importance<\/jats:title>\n Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP) in patients with uncontrolled hypertension (HTN). Establishing the magnitude and consistency of the uRDN effect across the HTN spectrum is clinically important.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To characterize the effectiveness and safety of uRDN vs a sham procedure from individual patient-level pooled data across uRDN trials including either patients with mild to moderate HTN on a background of no medications or with HTN resistant to standardized triple-combination therapy.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n A Study of the ReCor Medical Paradise System in Clinical Hypertension (RADIANCE-HTN SOLO and TRIO) and A Study of the ReCor Medical Paradise System in Stage II Hypertension (RADIANCE II) trials.<\/jats:p>\n <\/jats:sec>\n \n Study Selection<\/jats:title>\n Trials with similar designs, standardized operational implementation (medication standardization and blinding of both patients and physicians to treatment assignment), and follow-up.<\/jats:p>\n <\/jats:sec>\n \n Data Extraction and Synthesis<\/jats:title>\n Pooled analysis using individual patient-level data using linear regression models to compare uRDN with sham across the trials.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was baseline-adjusted change in 2-month daytime ambulatory systolic BP (dASBP) between groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 506 patients were randomized in the 3 studies (uRDN, 293; sham, 213; mean [SD] age, 54.1 [9.3]; 354 male [70.0%]). After a 1-month medication stabilization period, dASBP was similar between the groups (mean [SD], uRDN, 150.3\u2009[9.2] mm Hg; sham, 150.8\u2009[10.5] mm Hg). At 2 months, dASBP decreased by 8.5 mm Hg to mean (SD) 141.8\u2009(13.8) mm Hg among patients treated with uRDN and by 2.9 mm Hg to 147.9\u2009(14.6) mm Hg among patients treated with a sham procedure (mean difference, \u22125.9; 95% CI, \u22128.1 to \u22123.8 mm Hg;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001 in favor of uRDN). BP decreases from baseline with uRDN vs sham were consistent across trials and across BP parameters (office SBP: \u221210.4 mm Hg vs \u22123.4 mm Hg; mean difference, \u22126.4 mm Hg; 95% CI, \u22129.1 to \u20133.6 mm Hg; home SBP: \u22128.4 mm Hg vs \u22121.4 mm Hg; mean difference, \u22126.8 mm Hg; 95% CI, \u22128.7 to \u22124.9 mm Hg, respectively). The BP reductions with uRDN vs sham were consistent across prespecified subgroups. Independent predictors of a larger BP response to uRDN were higher baseline BP and heart rate and the presence of orthostatic hypertension. No differences in early safety end points were observed between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Results of this patient-level pooled analysis suggest that BP reductions with uRDN were consistent across HTN severity in sham-controlled trials designed with a 2-month primary end point to standardize medications across randomized groups.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT02649426<\/jats:ext-link>\n and\n NCT03614260<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamacardio.2023.0338","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T11:01:00Z","timestamp":1677582060000},"page":"464","source":"Crossref","is-referenced-by-count":87,"title":["Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials"],"prefix":"10.1001","volume":"8","author":[{"given":"Ajay J.","family":"Kirtane","sequence":"first","affiliation":[{"name":"Columbia University Medical Center\/NewYork-Presbyterian Hospital and the Cardiovascular Research Foundation, New York"},{"name":"Associate Editor, JAMA Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S. P.","family":"Sharp","sequence":"additional","affiliation":[{"name":"University Hospital of Wales and Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Saarland University Hospital, Homburg\/Saar, Germany"},{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi D. L.","family":"Fisher","sequence":"additional","affiliation":[{"name":"The Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin D.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Barts NIHR Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig, University of Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Basile","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Medical University of South Carolina, Ralph H. 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