{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:29:06Z","timestamp":1793464146719,"version":"4.5.0"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"\n Importance<\/jats:title>\n The existing models predicting right ventricular failure (RVF) after durable left ventricular assist device (LVAD) support might be limited, partly due to lack of external validation, marginal predictive power, and absence of intraoperative characteristics.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To derive and validate a risk model to predict RVF after LVAD implantation.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This was a hybrid prospective-retrospective multicenter cohort study conducted from April 2008 to July 2019 of patients with advanced heart failure (HF) requiring continuous-flow LVAD. The derivation cohort included patients enrolled at 5 institutions. The external validation cohort included patients enrolled at a sixth institution within the same period. Study data were analyzed October 2022 to August 2023.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Study participants underwent chronic continuous-flow LVAD support.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome and Measures<\/jats:title>\n The primary outcome was RVF incidence, defined as the need for RV assist device or intravenous inotropes for greater than 14 days. Bootstrap imputation and adaptive least absolute shrinkage and selection operator variable selection techniques were used to derive a predictive model. An RVF risk calculator (STOP-RVF) was then developed and subsequently externally validated, which can provide personalized quantification of the risk for LVAD candidates. Its predictive accuracy was compared with previously published RVF scores.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The derivation cohort included 798 patients (mean [SE] age, 56.1 [13.2] years; 668 male [83.7%]). The external validation cohort included 327 patients. RVF developed in 193 of 798 patients (24.2%) in the derivation cohort and 107 of 327 patients (32.7%) in the validation cohort. Preimplant variables associated with postoperative RVF included nonischemic cardiomyopathy, intra-aortic balloon pump, microaxial percutaneous left ventricular assist device\/venoarterial extracorporeal membrane oxygenation, LVAD configuration, Interagency Registry for Mechanically Assisted Circulatory Support profiles 1 to 2, right atrial\/pulmonary capillary wedge pressure ratio, use of angiotensin-converting enzyme inhibitors, platelet count, and serum sodium, albumin, and creatinine levels. Inclusion of intraoperative characteristics did not improve model performance. The calculator achieved a C statistic of 0.75 (95% CI, 0.71-0.79) in the derivation cohort and 0.73 (95% CI, 0.67-0.80) in the validation cohort. Cumulative survival was higher in patients composing the low-risk group (estimated &amp;lt;20% RVF risk) compared with those in the higher-risk groups. The STOP-RVF risk calculator exhibited a significantly better performance than commonly used risk scores proposed by Kormos et al (C statistic, 0.58; 95% CI, 0.53-0.63) and Drakos et al (C statistic, 0.62; 95% CI, 0.57-0.67).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Implementing routine clinical data, this multicenter cohort study derived and validated the STOP-RVF calculator as a personalized risk assessment tool for the prediction of RVF and RVF-associated all-cause mortality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamacardio.2023.5372","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T11:33:18Z","timestamp":1706700798000},"page":"272","source":"Crossref","is-referenced-by-count":37,"title":["Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support"],"prefix":"10.1001","volume":"9","author":[{"given":"Iosif","family":"Taleb","sequence":"first","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos P.","family":"Kyriakopoulos","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Heart Failure, Mechanical Circulatory Support & Transplant, Inova Heart & Vascular Institute, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Demertzis","sequence":"additional","affiliation":[{"name":"Henry Ford Medical Center, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Sideris","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Wever-Pinzon","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigone G.","family":"Koliopoulou","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"},{"name":"Onassis Cardiac Surgery Center, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Bonios","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"},{"name":"Onassis Cardiac Surgery Center, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Shad","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, California"},{"name":"Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adithya","family":"Peruri","sequence":"additional","affiliation":[{"name":"Henry Ford Medical Center, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Hanff","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Dranow","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros V.","family":"Giannouchos","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"},{"name":"Department of Health Policy and Organization, School of Public Health, The University of Alabama at Birmingham, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Krauspe","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Zakka","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Tang","sequence":"additional","affiliation":[{"name":"Heart Failure, Mechanical Circulatory Support & Transplant, Inova Heart & Vascular Institute, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan W.","family":"Nemeh","sequence":"additional","affiliation":[{"name":"Henry Ford Medical Center, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Stehlik","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Fang","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig H.","family":"Selzman","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Alharethi","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Caine","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Cowger","sequence":"additional","affiliation":[{"name":"Henry Ford Medical Center, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hiesinger","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak","family":"Shah","sequence":"additional","affiliation":[{"name":"Heart Failure, Mechanical Circulatory Support & Transplant, Inova Heart & Vascular Institute, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros G.","family":"Drakos","sequence":"additional","affiliation":[{"name":"U.T.A.H. (Utah Transplant Affiliated Hospitals) Cardiac Transplant Program: University of Utah Health and School of Medicine, Intermountain Medical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"23","key":"hoi230077r1","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","article-title":"Advanced heart failure treated with continuous-flow left ventricular assist device.","volume":"361","author":"Slaughter","year":"2009","journal-title":"N Engl J Med"},{"issue":"5","key":"hoi230077r2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1056\/NEJMoa1602954","article-title":"Intrapericardial left ventricular assist device for advanced heart failure.","volume":"376","author":"Rogers","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"hoi230077r3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.healun.2005.07.008","article-title":"Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure.","volume":"25","author":"Dang","year":"2006","journal-title":"J Heart Lung Transplant"},{"issue":"12","key":"hoi230077r4","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.healun.2008.08.012","article-title":"Tricuspid incompetence and geometry of the right ventricle as predictors of right ventricular function after implantation of a left ventricular assist device.","volume":"27","author":"Potapov","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"hoi230077r5","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.jtcvs.2009.11.020","article-title":"Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes.","volume":"139","author":"Kormos","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"12","key":"hoi230077r6","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.healun.2008.09.006","article-title":"Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support.","volume":"27","author":"Fitzpatrick","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"22","key":"hoi230077r7","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.jacc.2008.03.009","article-title":"The right ventricular failure risk score a preoperative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates.","volume":"51","author":"Matthews","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"hoi230077r8","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.jtcvs.2008.09.021","article-title":"Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device.","volume":"137","author":"Fitzpatrick","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"hoi230077r9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.healun.2013.06.025","article-title":"Outcome of unplanned right ventricular assist device support for severe right heart failure after implantable left ventricular assist device insertion.","volume":"33","author":"Takeda","year":"2014","journal-title":"J Heart Lung Transplant"},{"issue":"9","key":"hoi230077r10","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.healun.2018.05.001","article-title":"Multicenter experience with durable biventricular assist devices.","volume":"37","author":"Shah","year":"2018","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"hoi230077r11","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.athoracsur.2020.12.038","article-title":"The Society of Thoracic Surgeons INTERMACS 2020 Annual Report.","volume":"111","author":"Molina","year":"2021","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"hoi230077r12","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.athoracsur.2013.03.099","article-title":"Predicting right ventricular failure in the modern, continuous flow left ventricular assist device era.","volume":"96","author":"Atluri","year":"2013","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"hoi230077r13","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.amjcard.2009.11.026","article-title":"Risk factors predictive of right ventricular failure after left ventricular assist device implantation.","volume":"105","author":"Drakos","year":"2010","journal-title":"Am J Cardiol"},{"issue":"9","key":"hoi230077r14","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1161\/CIRCULATIONAHA.117.030543","article-title":"Derivation and validation of a novel right-sided heart failure model after implantation of continuous flow left ventricular assist devices: The EUROMACS (European Registry for Patients with Mechanical Circulatory Support) right-sided heart failure risk score.","volume":"137","author":"Soliman","year":"2018","journal-title":"Circulation"},{"issue":"10","key":"hoi230077r15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.006994","article-title":"Predicting the risk of right ventricular failure in patients undergoing left ventricular assist device implantation: a systematic review.","volume":"13","author":"Frankfurter","year":"2020","journal-title":"Circ Heart Fail"},{"issue":"1","key":"hoi230077r17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"hoi230077r18","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/biostatistics\/kxv003","article-title":"Variable selection in the presence of missing data: resampling and imputation.","volume":"16","author":"Long","year":"2015","journal-title":"Biostatistics"},{"issue":"476","key":"hoi230077r19","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1198\/016214506000000735","article-title":"The adaptive lasso and its oracle properties.","volume":"101","author":"Zou","year":"2006","journal-title":"J Am Stat Assoc"},{"issue":"1","key":"hoi230077r23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1751-5823.2010.00103.x","article-title":"A review of hot deck imputation for survey nonresponse.","volume":"78","author":"Andridge","year":"2010","journal-title":"Int Stat Rev"},{"issue":"6","key":"hoi230077r24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R","article-title":"Multiple imputation of missing blood pressure covariates in survival analysis.","volume":"18","author":"van Buuren","year":"1999","journal-title":"Stat Med"},{"issue":"3","key":"hoi230077r25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1536867X0400400301","article-title":"Multiple imputation of missing values.","volume":"4","author":"Royston","year":"2004","journal-title":"Stata J"},{"issue":"3","key":"hoi230077r26","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/1536867X0900900308","article-title":"Multiple imputation of missing values: further update of ice, with an emphasis on categorical variables.","volume":"9","author":"Royston","year":"2009","journal-title":"Stata J"},{"issue":"3","key":"hoi230077r28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under 2 or more correlated receiver operating characteristic curves: a nonparametric approach.","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"issue":"12","key":"hoi230077r30","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.healun.2015.05.005","article-title":"Validation of clinical scores for right ventricular failure prediction after implantation of continuous-flow left ventricular assist devices.","volume":"34","author":"Kalogeropoulos","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"10","key":"hoi230077r31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.003863","article-title":"Early right ventricular assist device use in patients undergoing continuous-flow left ventricular assist device implantation: incidence and risk factors from the interagency registry for mechanically assisted circulatory support.","volume":"10","author":"Kiernan","year":"2017","journal-title":"Circ Heart Fail"},{"issue":"9","key":"hoi230077r32","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.healun.2015.05.013","article-title":"Apples, oranges, and statistical magic: Limitations of registry studies and need for collaborative studies.","volume":"34","author":"Urschel","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"hoi230077r27","doi-asserted-by":"crossref","DOI":"10.1002\/9780470316696","volume-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"1987"},{"key":"hoi230077r16","unstructured":"STS Intermacs. INTERMACS adverse event definitions: adult and pediatric patients. Accessed October 2, 2021. https:\/\/intermacs.kirso.net\/wp-content\/uploads\/pedimacs\/AE_Definitions_Final_02-4-2016.docx"},{"key":"hoi230077r20","doi-asserted-by":"crossref","unstructured":"Bach? F. Bolasso: model consistent Lasso estimation through the bootstrap.? arXiv. Preprint posted online April 8, 2008. doi:10.1145\/1390156.1390161","DOI":"10.1145\/1390156.1390161"},{"key":"hoi230077r21","unstructured":"Bach? F. Model-consistent sparse estimation through the bootstrap.? arXiv. Preprint posted online January 21, 2009. doi:10.48550\/arXiv.0901.3202"},{"key":"hoi230077r22","unstructured":"EconPapers. HOTDECKVAR: Stata module for hotdeck imputation. Accessed November 17, 2021. https:\/\/EconPapers.repec.org\/RePEc:boc:bocode:s458527"},{"key":"hoi230077r29","unstructured":"DRAKOS LAB. STOP-RVF risk calculator. Accessed December 15, 2023. https:\/\/cvrti.utah.edu\/drakos\/Site\/tools.html"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2814371\/jamacardiology_taleb_2024_oi_230077_1714758117.75509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T14:00:45Z","timestamp":1714744845000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2814371"}},"subtitle":["The STOP-RVF Score"],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2023.5372","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}