{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:33:35Z","timestamp":1794447215533,"version":"4.9.1"},"reference-count":20,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec id=\"ab-hoi240038-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>There are currently no pharmacological treatments available to slow hemodynamic progression of aortic stenosis. Plasma lipoprotein(a) concentrations predict incident aortic stenosis but its association with hemodynamic progression is controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi240038-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the association between plasma lipoprotein(a) concentrations and hemodynamic progression in patients with aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi240038-6\">\n                    <jats:title>Design, Settings and Participants<\/jats:title>\n                    <jats:p>The study included patients with aortic stenosis from 5 longitudinal clinical studies conducted from March 2001 to March 2023 in Canada and the UK. Of 757 total patients, data on plasma lipoprotein(a) concentrations and rates of hemodynamic progression assessed by echocardiography were available for 710, who were included in this analysis. Data were analyzed from March 2023 to April 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi240038-7\">\n                    <jats:title>Exposure<\/jats:title>\n                    <jats:p>Cohort-specific plasma lipoprotein(a) concentration tertiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi240038-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Hemodynamic aortic stenosis progression on echocardiography as assessed by annualized change in peak aortic jet velocity, mean transvalvular gradient, and aortic valve area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi240038-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the included patients, 497 (70%) were male and 213 (30%) were female. The mean (SD) age was 65.2 (13.1) years. Patients in the top lipoprotein(a) tertile demonstrated 41% (estimate, 1.41; 95% CI, 1.13-1.75) faster progression of peak aortic jet velocity and 57% (estimate, 1.57; 95% CI, 1.18-2.10) faster progression of mean transvalvular gradient than patients in the bottom tertile. There was no evidence of heterogeneity across the individual cohorts. Progression of aortic valve area was comparable between groups (estimate, 1.23; 95% CI, 0.71-2.12). Similar results were observed when plasma lipoprotein(a) concentrations were treated as a continuous variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi240038-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this study, higher plasma lipoprotein(a) concentrations were associated with faster rates of hemodynamic progression in patients with aortic stenosis. Lowering plasma lipoprotein(a) concentrations warrants further investigation in the prevention and treatment of aortic stenosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamacardio.2024.1882","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T11:01:52Z","timestamp":1721214112000},"page":"835","source":"Crossref","is-referenced-by-count":87,"title":["Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression"],"prefix":"10.1001","volume":"9","author":[{"given":"Benoit J.","family":"Arsenault","sequence":"first","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika","family":"Loganath","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Girard","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Botezatu","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"},{"name":"University of Medicine and Pharmacy Carol Davila, Cardiology Department, Euroecolab, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang H.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Department of Cardiology, Onze Lieve Vrouwe Gasthuis Hospital, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Tzolos","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathia","family":"Abdoun","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Tastet","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Capoulade","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre hospitalier universitaire Nantes, Centre national de recherche scientifique, Institut national de la sant\u00e9 et de la recherche m\u00e9dicale, l\u2019institut du thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Craig","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Boniface General Hospital, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon K.","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology), McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Couture","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Department of Surgery, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Th\u00e9riault","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S. G.","family":"Stroes","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Tsimikas","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Department of Medicine, University of California, San Diego, La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"key":"hoi240038r1","doi-asserted-by":"publisher","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis.","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"hoi240038r2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa1109034","article-title":"Genetic associations with valvular calcification and aortic stenosis.","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N Engl J Med"},{"issue":"5","key":"hoi240038r3","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"hoi240038r4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1161\/CIRCGENETICS.113.000400","article-title":"Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective mendelian randomization study and replication in a case-control cohort.","volume":"7","author":"Arsenault","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"issue":"5","key":"hoi240038r5","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.jacc.2015.05.066","article-title":"Calcification in aortic stenosis: the skeleton key.","volume":"66","author":"Pawade","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"39","key":"hoi240038r6","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1093\/eurheartj\/ehac377","article-title":"Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification.","volume":"43","author":"Kaiser","year":"2022","journal-title":"Eur Heart J"},{"issue":"17","key":"hoi240038r7","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1016\/j.jacc.2019.01.070","article-title":"Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis.","volume":"73","author":"Zheng","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"hoi240038r8","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.jacc.2015.07.020","article-title":"Oxidized phospholipids, lipoprotein(a), and progression of calcific aortic valve stenosis.","volume":"66","author":"Capoulade","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"hoi240038r9","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1161\/CIRCULATIONAHA.109.900027","article-title":"Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial.","volume":"121","author":"Chan","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"hoi240038r10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.111.051052","article-title":"Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis.","volume":"125","author":"Dweck","year":"2012","journal-title":"Circulation"},{"issue":"23","key":"hoi240038r11","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1056\/NEJMoa043876","article-title":"A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.","volume":"352","author":"Cowell","year":"2005","journal-title":"N Engl J Med"},{"issue":"4","key":"hoi240038r12","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007980","article-title":"ApoB\/apoA-I ratio is associated with faster hemodynamic progression of aortic stenosis: results from the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study.","volume":"7","author":"Tastet","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"hoi240038r13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.cjco.2019.03.004","article-title":"Lipoprotein(a), oxidized phospholipids, and aortic valve microcalcification assessed by 18f-sodium fluoride positron emission tomography and computed tomography.","volume":"1","author":"Despr\u00e9s","year":"2019","journal-title":"CJC Open"},{"issue":"25","key":"hoi240038r14","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1161\/CIRCULATIONAHA.121.053708","article-title":"Effect of denosumab or alendronic acid on the progression of aortic stenosis: a double-blind randomized controlled trial.","volume":"143","author":"Pawade","year":"2021","journal-title":"Circulation"},{"issue":"7","key":"hoi240038r15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/ehjci\/jeaa068","article-title":"Effect of bicuspid aortic valve phenotype on progression of aortic stenosis.","volume":"21","author":"Shen","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"hoi240038r16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.atherosclerosis.2020.09.010","article-title":"Lipoprotein(a) and aortic valve calcium in South Asians compared to other race\/ethnic groups.","volume":"313","author":"Makshood","year":"2020","journal-title":"Atherosclerosis"},{"issue":"8","key":"hoi240038r17","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1093\/cvr\/cvad062","article-title":"Lipoprotein(a) and calcific aortic valve disease initiation and progression: a systematic review and meta-analysis.","volume":"119","author":"Pantelidis","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"23","key":"hoi240038r18","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1016\/j.jacc.2021.09.1367","article-title":"Evaluating medical therapy for calcific aortic stenosis: JACC state-of-the-art review.","volume":"78","author":"Lindman","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"hoi240038r19","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1136\/heartjnl-2020-317125","article-title":"Computed tomography aortic valve calcium scoring for the assessment of aortic stenosis progression.","volume":"106","author":"Doris","year":"2020","journal-title":"Heart"},{"issue":"3","key":"hoi240038r20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.jcmg.2022.10.009","article-title":"Aortic stenosis progression: a systematic review and meta-analysis.","volume":"16","author":"Willner","year":"2023","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2820718\/jamacardiology_arsenault_2024_oi_240038_1725982858.51539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T11:41:01Z","timestamp":1726054861000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2820718"}},"subtitle":["A Systematic Review and Meta-Analysis"],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2024.1882","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,1]]}}}