{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T14:34:09Z","timestamp":1794062049109,"version":"4.8.0"},"reference-count":70,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec id=\"ab-hoi250044-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Sleep disordered breathing (SDB) is a well-established contributor to cardiovascular morbidity, mediated by intermittent hypoxemia, autonomic dysregulation, and endothelial dysfunction. Patients with hypertrophic cardiomyopathy (HCM) may be especially at risk for SDB, but the clinical impact of SDB in this population remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi250044-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To define the prevalence and subtypes of SDB in HCM and examine their association with echocardiographic parameters and cardiac biomarker expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi250044-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted between April 18, 2018, and January 15, 2024, at a single tertiary referral center specializing in HCM care. Adults with HCM (left ventricular wall thickness \u226515 mm or pathogenic variants) were recruited from an institutional registry. Patients diagnosed with SDB or current pregnancy were excluded. Patients underwent polysomnography, with comparative assessment of echocardiographic, electrocardiographic, and biomarker indices. Observers were blinded to polysomnographic results. Data analysis was performed from April 11, 2024, to July 25, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi250044-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>SDB classified via polysomnography using apnea-hypopnea index thresholds, with subtypes including obstructive sleep apnea and central sleep apnea and with event severity, hypoxemia, and sleep architecture disruption quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi250044-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Echocardiographic indices, cardiac biomarker expression, functional status, apnea-hypopnea index, and overnight hypoxemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi250044-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 154 patients (median [IQR] age, 60 [48-68] years; 102 [66.2%] male), 91 (59.1%) were diagnosed with SDB. Those with SDB, compared with those without SDB, had higher left ventricular mass index (median [IQR], 128 [107-161] vs 109 [96-134] g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03), E\/e\u2032 ratio (median [IQR], 12.5 [10.0-15.0] vs 10.0 [8.3-14.5];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04), and baseline troponin-T level (median [IQR], 0.013 [0.009-0.022] vs 0.011 [0.007-0.015] ng\/mL [to convert to micrograms per liter, multiply by 1];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04) and greater overnight troponin-T level increases (change in median [IQR], 0.0021 [\u22120.0029 to 0.0062] vs 0.0002 [\u22120.0022 to 0.0026] ng\/mL;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02). New York Heart Association class II or III symptoms were more common in those with SDB (48 [52.7%] vs 17 [27.0%];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005). Hypertension and diabetes were more prevalent among patients with SDB than without SDB (hypertension: 67 [73.6%] vs 36 [57.1%];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03; diabetes: 14 [15.4%] vs 3 [4.8%];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04), whereas rates of atrial fibrillation and prior myectomy did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hoi250044-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>This study suggests that undiagnosed SDB is highly prevalent in patients with HCM and that SDB is associated with adverse myocardial remodeling, greater diastolic dysfunction, and elevated troponin-T levels, indicating subclinical myocardial injury. SDB may contribute to HCM pathophysiology and symptom burden, supporting the rationale for randomized clinical trials to determine the impact of treating SDB on symptoms and clinical outcomes in patients with HCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamacardio.2025.2877","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T15:00:26Z","timestamp":1756911626000},"page":"1024","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Clinical Implications of Sleep Apnea in Hypertrophic Cardiomyopathy"],"prefix":"10.1001","volume":"10","author":[{"given":"Shahid","family":"Karim","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"},{"name":"William Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Chahal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"},{"name":"William Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University London, London, United Kingdom"},{"name":"Center for Inherited Cardiovascular Diseases, WellSpan Health, York, Pennsylvania"},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyas","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Washington University in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek J.","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos C.","family":"Siontis","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Mansukhani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Konecny","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Florida, Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Y.","family":"Khanji","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University London, London, United Kingdom"},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, United Kingdom"},{"name":"Newham University Hospital, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen E.","family":"Petersen","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University London, London, United Kingdom"},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London, United Kingdom"},{"name":"Health Data Research UK, London, United Kingdom"},{"name":"Alan Turing Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Geske","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virend K.","family":"Somers","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"12","key":"hoi250044r1","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jacc.2015.01.019","article-title":"New perspectives on the prevalence of hypertrophic cardiomyopathy.","volume":"65","author":"Semsarian","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"hoi250044r2","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.jchf.2018.03.004","article-title":"Global burden of hypertrophic cardiomyopathy.","volume":"6","author":"Maron","year":"2018","journal-title":"JACC Heart Fail"},{"issue":"4","key":"hoi250044r3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA Study.","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"issue":"1","key":"hoi250044r4","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010440","article-title":"Obstructive sleep apnea in cardiovascular disease: a review of the literature and proposed multidisciplinary clinical management strategy.","volume":"8","author":"Tietjens","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"hoi250044r5","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.cjca.2021.01.027","article-title":"Obstructive sleep apnea as a cardiovascular risk factor\u2014beyond CPAP.","volume":"37","author":"Bock","year":"2021","journal-title":"Can J Cardiol"},{"issue":"13","key":"hoi250044r6","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.jacc.2024.02.059","article-title":"Interactions of obstructive sleep apnea with the pathophysiology of cardiovascular disease, part 1: JACC state-of-the-art review.","volume":"84","author":"Javaheri","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"13","key":"hoi250044r7","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.jacc.2024.07.024","article-title":"Treatment of OSA and its impact on cardiovascular disease, part 2: JACC state-of-the-art review.","volume":"84","author":"Javaheri","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"hoi250044r8","doi-asserted-by":"publisher","first-page":"13528","DOI":"10.1038\/s41598-021-93039-5","article-title":"Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy.","volume":"11","author":"Xu","year":"2021","journal-title":"Sci Rep"},{"issue":"19","key":"hoi250044r9","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1016\/j.jacc.2009.07.030","article-title":"High prevalence of abnormal nocturnal oximetry in patients with hypertrophic cardiomyopathy.","volume":"54","author":"Eleid","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"hoi250044r10","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1378\/chest.14-1498","article-title":"Decreased exercise capacity and sleep-disordered breathing in patients with hypertrophic cardiomyopathy.","volume":"147","author":"Konecny","year":"2015","journal-title":"Chest"},{"issue":"9","key":"hoi250044r11","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/j.mayocp.2021.03.036","article-title":"Sleep disordered breathing and mortality in patients with hypertrophic obstructive cardiomyopathy undergoing septal myectomy.","volume":"96","author":"Cui","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"hoi250044r12","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"issue":"4","key":"hoi250044r14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/diseases9040088","article-title":"Association and risk factors for obstructive sleep apnea and cardiovascular diseases: a systematic review.","volume":"9","author":"Mitra","year":"2021","journal-title":"Diseases"},{"issue":"3","key":"hoi250044r15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.5664\/jcsm.1928","article-title":"The AASM Scoring Manual four years later.","volume":"8","author":"Grigg-Damberger","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"hoi250044r16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review.","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"8","key":"hoi250044r17","first-page":"1311","article-title":"Obstructive sleep apnea is a common disorder in the population\u2014a review on the epidemiology of sleep apnea.","volume":"7","author":"Franklin","year":"2015","journal-title":"J Thorac Dis"},{"issue":"6","key":"hoi250044r18","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.jopan.2023.01.018","article-title":"Global prevalence of obstructive sleep apnea in the elderly and related factors: a systematic review and meta-analysis study.","volume":"38","author":"Ghavami","year":"2023","journal-title":"J Perianesth Nurs"},{"issue":"1","key":"hoi250044r19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1164\/ajrccm.163.1.2001008","article-title":"Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study.","volume":"163","author":"Shahar","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"hoi250044r20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11325-022-02611-4","article-title":"Prevalence and clinical characteristics of sleep-disordered breathing in patients with heart failure of different left ventricular ejection fractions.","volume":"27","author":"Wang","year":"2023","journal-title":"Sleep Breath"},{"issue":"7","key":"hoi250044r21","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.jacc.2016.11.069","article-title":"Sleep apnea: types, mechanisms, and clinical cardiovascular consequences.","volume":"69","author":"Javaheri","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"hoi250044r22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jjcc.2012.05.013","article-title":"Sleep apnea and heart failure.","volume":"60","author":"Kasai","year":"2012","journal-title":"J Cardiol"},{"issue":"5","key":"hoi250044r23","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01640-2021","article-title":"Sleep apnoea and heart failure.","volume":"59","author":"L\u00e9vy","year":"2022","journal-title":"Eur Respir J"},{"issue":"8","key":"hoi250044r24","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015013","article-title":"Implication of apnea-hypopnea index, a measure of obstructive sleep apnea severity, for atrial fibrillation in patients with hypertrophic cardiomyopathy.","volume":"9","author":"Xu","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"hoi250044r25","doi-asserted-by":"publisher","first-page":"e2309","DOI":"10.1210\/clinem\/dgab015","article-title":"Association between obstructive sleep apnea and metabolic abnormalities in patients with hypertrophic cardiomyopathy.","volume":"106","author":"Wang","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"hoi250044r26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1751-7133.2010.00196.x","article-title":"Incidence of sleep-disordered breathing in patients with hypertrophic cardiomyopathy.","volume":"17","author":"Prinz","year":"2011","journal-title":"Congest Heart Fail"},{"issue":"4","key":"hoi250044r27","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3390\/jcm9040901","article-title":"Sleep disordered breathing in hypertrophic cardiomyopathy\u2014current state and future directions.","volume":"9","author":"Venkataraman","year":"2020","journal-title":"J Clin Med"},{"issue":"3","key":"hoi250044r28","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline.","volume":"13","author":"Kapur","year":"2017","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"hoi250044r29","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1172\/JCI118235","article-title":"Sympathetic neural mechanisms in obstructive sleep apnea.","volume":"96","author":"Somers","year":"1995","journal-title":"J Clin Invest"},{"issue":"1","key":"hoi250044r30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/ncpcardio1401","article-title":"Hypertrophic obstructive cardiomyopathy and sleep-disordered breathing: an unfavorable combination.","volume":"6","author":"Sengupta","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"4","key":"hoi250044r31","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/clinchem\/hvaa023","article-title":"Cardiac troponin I and T are associated with left ventricular function and structure: data from the Akershus Cardiac Examination 1950 study.","volume":"66","author":"Lyngbakken","year":"2020","journal-title":"Clin Chem"},{"issue":"7","key":"hoi250044r32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.jacc.2008.04.047","article-title":"Assessment and significance of left ventricular mass by cardiovascular magnetic resonance in hypertrophic cardiomyopathy.","volume":"52","author":"Olivotto","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"hoi250044r33","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac113","article-title":"Central sleep apnea: pathophysiologic classification.","volume":"46","author":"Javaheri","year":"2023","journal-title":"Sleep"},{"issue":"3","key":"hoi250044r34","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae307","article-title":"Central sleep apnea and cardiovascular disease state-of-the-art.","volume":"48","author":"Javaheri","year":"2025","journal-title":"Sleep"},{"issue":"1","key":"hoi250044r35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1152\/japplphysiol.01617.2005","article-title":"Increased propensity for apnea in response to acute elevations in left atrial pressure during sleep in the dog.","volume":"101","author":"Chenuel","year":"2006","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"hoi250044r36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1161\/CIRCHEARTFAILURE.111.965814","article-title":"Differing relationship of nocturnal fluid shifts to sleep apnea in men and women with heart failure.","volume":"5","author":"Kasai","year":"2012","journal-title":"Circ Heart Fail"},{"issue":"6","key":"hoi250044r37","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1164\/ajrccm.162.6.2002024","article-title":"Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure.","volume":"162","author":"Solin","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"hoi250044r38","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1378\/chest.09-2335","article-title":"Obstructive sleep apnea is common and independently associated with atrial fibrillation in patients with hypertrophic cardiomyopathy.","volume":"137","author":"Pedrosa","year":"2010","journal-title":"Chest"},{"issue":"10","key":"hoi250044r39","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/clc.23429","article-title":"Effect of obstructive sleep apnea on right ventricular ejection fraction in patients with hypertrophic obstructive cardiomyopathy.","volume":"43","author":"Wang","year":"2020","journal-title":"Clin Cardiol"},{"issue":"5","key":"hoi250044r40","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.hrthm.2018.12.017","article-title":"Obstructive sleep apnea is associated with nonsustained ventricular tachycardia in patients with hypertrophic obstructive cardiomyopathy.","volume":"16","author":"Wang","year":"2019","journal-title":"Heart Rhythm"},{"issue":"4","key":"hoi250044r41","doi-asserted-by":"publisher","DOI":"10.1111\/anec.70077","article-title":"Late gadolinium enhancement and electrocardiographic associations in hypertrophic cardiomyopathy.","volume":"30","author":"Asfour","year":"2025","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"5","key":"hoi250044r42","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1378\/chest.06-2703","article-title":"Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling.","volume":"131","author":"Drager","year":"2007","journal-title":"Chest"},{"issue":"6","key":"hoi250044r43","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1378\/chest.107.6.1538","article-title":"Cardiac hypertrophy in obstructive sleep apnea syndrome.","volume":"107","author":"Noda","year":"1995","journal-title":"Chest"},{"issue":"5","key":"hoi250044r44","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jacc.2004.11.046","article-title":"Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study.","volume":"45","author":"Dhingra","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"hoi250044r45","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/jsr.12501","article-title":"Association between central sleep apnea and left ventricular structure: the Multi-Ethnic Study of Atherosclerosis.","volume":"26","author":"Javaheri","year":"2017","journal-title":"J Sleep Res"},{"issue":"1","key":"hoi250044r46","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.sleep.2006.04.007","article-title":"Effects of CPAP on left ventricular structure and myocardial performance index in male patients with obstructive sleep apnoea.","volume":"8","author":"Dursunoglu","year":"2007","journal-title":"Sleep Med"},{"issue":"8","key":"hoi250044r47","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.hrthm.2013.05.009","article-title":"Resting heart rate and risk of sudden cardiac death in the general population: influence of left ventricular systolic dysfunction and heart rate-modulating drugs.","volume":"10","author":"Teodorescu","year":"2013","journal-title":"Heart Rhythm"},{"issue":"3","key":"hoi250044r48","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1093\/sleep\/29.3.375","article-title":"Practice parameters for the use of continuous and bilevel positive airway pressure devices to treat adult patients with sleep-related breathing disorders.","volume":"29","author":"Kushida","year":"2006","journal-title":"Sleep"},{"issue":"12","key":"hoi250044r49","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.5665\/sleep.2226","article-title":"Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the Apnea Positive Pressure Long-Term Efficacy Study (APPLES).","volume":"35","author":"Kushida","year":"2012","journal-title":"Sleep"},{"issue":"9170","key":"hoi250044r50","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1016\/S0140-6736(98)10532-9","article-title":"Comparison of therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised prospective parallel trial.","volume":"353","author":"Jenkinson","year":"1999","journal-title":"Lancet"},{"issue":"6","key":"hoi250044r51","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01033-2024","article-title":"Treating sleep disordered breathing for cardiovascular outcomes: observational and randomised trial evidence.","volume":"64","author":"Bradley","year":"2024","journal-title":"Eur Respir J"},{"issue":"2","key":"hoi250044r52","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S2213-2600(23)00374-0","article-title":"Adaptive servo-ventilation for sleep-disordered breathing in patients with heart failure with reduced ejection fraction (ADVENT-HF): a multicentre, multinational, parallel-group, open-label, phase 3 randomised controlled trial.","volume":"12","author":"Bradley","year":"2024","journal-title":"Lancet Respir Med"},{"issue":"20","key":"hoi250044r53","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1161\/01.CIR.0000068337.25994.21","article-title":"Obstructive sleep apnea and the recurrence of atrial fibrillation.","volume":"107","author":"Kanagala","year":"2003","journal-title":"Circulation"},{"issue":"1-2","key":"hoi250044r54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jacep.2015.02.014","article-title":"Effect of obstructive sleep apnea treatment on atrial fibrillation recurrence: a meta-analysis.","volume":"1","author":"Shukla","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"issue":"10","key":"hoi250044r55","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1056\/NEJMoa1606599","article-title":"CPAP for prevention of cardiovascular events in obstructive sleep apnea.","volume":"375","author":"McEvoy","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"hoi250044r56","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1001\/jama.2017.7967","article-title":"Association of positive airway pressure with cardiovascular events and death in adults with sleep apnea: a systematic review and meta-analysis.","volume":"318","author":"Yu","year":"2017","journal-title":"JAMA"},{"key":"hoi250044r57","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101312","article-title":"Efficacy of continuous positive airway pressure (CPAP) in the prevention of cardiovascular events in patients with obstructive sleep apnea: systematic review and meta-analysis.","volume":"52","author":"Labarca","year":"2020","journal-title":"Sleep Med Rev"},{"issue":"12","key":"hoi250044r58","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","article-title":"Adaptive servo-ventilation for central sleep apnea in systolic heart failure.","volume":"373","author":"Cowie","year":"2015","journal-title":"N Engl J Med"},{"issue":"2","key":"hoi250044r59","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1164\/rccm.201912-2511OC","article-title":"Effects of weight loss on obstructive sleep apnea severity: ten-year results of the Sleep AHEAD study.","volume":"203","author":"Kuna","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"hoi250044r60","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1513\/AnnalsATS.201810-708CME","article-title":"Clinical practice guideline summary for clinicians: the role of weight management in the treatment of adult obstructive sleep apnea.","volume":"16","author":"Billings","year":"2019","journal-title":"Ann Am Thorac Soc"},{"issue":"1","key":"hoi250044r61","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/jamacardio.2019.4268","article-title":"Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy.","volume":"5","author":"Fumagalli","year":"2020","journal-title":"JAMA Cardiol"},{"issue":"4","key":"hoi250044r62","doi-asserted-by":"publisher","first-page":"357","DOI":"10.7861\/clinmed.2023-0194","article-title":"The weight of obesity in hypertrophic cardiomyopathy.","volume":"23","author":"Zaromytidou","year":"2023","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"hoi250044r63","doi-asserted-by":"publisher","first-page":"823","DOI":"10.5664\/jcsm.10420","article-title":"Distinguishing central from obstructive hypopneas on a clinical polysomnogram.","volume":"19","author":"Javaheri","year":"2023","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"hoi250044r64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/14779072.2023.2159811","article-title":"An evaluation of mavacamten for the treatment of symptomatic obstructive hypertrophic cardiomyopathy in adults.","volume":"21","author":"Dong","year":"2023","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"8","key":"hoi250044r65","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030607","article-title":"Long-term safety and efficacy of mavacamten in symptomatic obstructive hypertrophic cardiomyopathy: interim results of the PIONEER-OLE study.","volume":"13","author":"Masri","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"10253","key":"hoi250044r66","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial.","volume":"396","author":"Olivotto","year":"2020","journal-title":"Lancet"},{"issue":"9","key":"hoi250044r67","doi-asserted-by":"publisher","first-page":"949","DOI":"10.33963\/KP.a2021.0064","article-title":"Mavacamten\u2014a new disease-specific option for pharmacological treatment of symptomatic patients with hypertrophic cardiomyopathy.","volume":"79","author":"Pysz","year":"2021","journal-title":"Kardiol Pol"},{"issue":"10293","key":"hoi250044r68","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/S0140-6736(21)00763-7","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.","volume":"397","author":"Spertus","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"hoi250044r69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301704","article-title":"Evaluating the efficacy and safety of mavacamten in hypertrophic cardiomyopathy: a systematic review and meta-analysis focusing on qualitative assessment, biomarkers, and cardiac imaging.","volume":"19","author":"Vyas","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"hoi250044r70","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s10741-023-10375-6","article-title":"A systematic review and meta-analysis of the efficacy and safety of mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.","volume":"29","author":"Yacoub","year":"2024","journal-title":"Heart Fail Rev"},{"key":"hoi250044r13","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Version 2.6","author":"American Academy of Sleep Medicine","year":"2020"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2838521\/jamacardiology_karim_2025_oi_250044_1758588892.09511.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:01:54Z","timestamp":1759935714000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2838521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2025.2877","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}