{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:21:44Z","timestamp":1790144504323,"version":"4.0.1"},"reference-count":79,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec id=\"ab-hrv250003-1\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Primary mitral regurgitation (MR) is a prevalent valvular lesion. Current American College of Cardiology\/American Heart Association guidelines include class I recommendations for intervention for severe primary MR at the onset of symptoms, significant left ventricular (LV) enlargement (end-systolic dimension \u226540 mm), or dysfunction (ejection fraction \u226460%), with a class IIA recommendation for mitral valve repair when performed at an experienced surgical center. Recent data suggest a survival penalty when waiting for class I surgical guideline indications, and novel markers of decompensation are under investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hrv250003-2\">\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>Comprehensive assessment of MR severity using echocardiography is critical, and when warranted, cardiac magnetic resonance (CMR) is complementary. Assessment of LV size and function, as well as serial changes in both, is crucial for determining timing of surgery. New-onset atrial fibrillation, left atrial enlargement, pulmonary hypertension, and exercise-induced changes in LV function should also be considered in borderline scenarios. The roles of LV volumes, global longitudinal strain, CMR-derived measures of myocardial dysfunction, and cardiac biomarkers are worthy of further investigation regarding consideration for early surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-hrv250003-3\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>A more refined approach incorporating assessment of extravalvular cardiac injury, novel imaging markers, and biomarkers is needed to optimize surgical timing in primary MR. Further research is warranted to validate these emerging parameters and refine guidelines to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamacardio.2025.4561","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:00:25Z","timestamp":1765987225000},"page":"199","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial Dysfunction in Primary Mitral Regurgitation"],"prefix":"10.1001","volume":"11","author":[{"given":"Vidhu","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Bonow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Editor, JAMA Cardiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick 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