{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T08:45:51Z","timestamp":1794473151508,"version":"4.9.1"},"reference-count":20,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"\n Importance<\/jats:title>\n The optimal dual antiplatelet therapy after percutaneous coronary intervention (PCI) in patients with diabetes is not clearly defined. Although both ticagrelor and prasugrel are potent inhibitors of P2Y purinergic receptor 12 (P2Y12), evidence directly comparing their efficacy and safety in this high-risk group remains limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To compare the clinical outcomes of ticagrelor vs prasugrel, each in combination with aspirin, in patients with diabetes and multivessel coronary artery disease who underwent percutaneous coronary intervention.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n The Ultrathin Strut vs Xience in a Diabetic Population With Multivessel Disease 2\u2014India Study (TUXEDO-2) is an investigator-initiated, prospective, open-label, multicenter, 2\u2009\u00d7\u20092 factorial design, 1:1 randomized clinical trial. Participants with diabetes and multivessel disease undergoing percutaneous coronary intervention were enrolled at 66 clinical sites from February 2020 to August 2024.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Patients undergoing percutaneous coronary intervention were randomized to receive either ticagrelor or prasugrel, each in combination with low-dose aspirin.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was a composite of death, nonfatal myocardial infarction, stroke, or major bleeding as defined by the Bleeding Academic Research Consortium at 1 year. The trial was designed to test the noninferiority of ticagrelor compared with prasugrel with a noninferiority margin of 5%.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among the 1800 participants randomized, mean (SD) age was 60 (10) years with 1296 (72.0%) male participants, 436 (24.2%) receiving insulin therapy, and 1530 (85.0%) with triple-vessel disease. At 1 year, the primary end point occurred in 129 participants (16.6%) taking ticagrelor and 107 participants (14.2%) taking prasugrel (\n P<\/jats:italic>\n \u2009=\u2009.12). The risk difference of 2.33 percentage points (95% CI, \u22122.07 to 6.74 percentage points) failed to meet the prespecified threshold for noninferiority (\n P<\/jats:italic>\n \u2009=\u2009.84). There was numerically higher (but not statistically significant) composite of death, myocardial infarction, stroke (10.43% vs 8.63%;\n P<\/jats:italic>\n \u2009=\u2009.30), and major bleeding (8.41% vs 7.14%;\n P<\/jats:italic>\n \u2009=\u2009.19) with ticagrelor when compared with prasugrel.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In patients with diabetes and multivessel disease undergoing PCI, ticagrelor was not noninferior to prasugrel for the reduction of primary outcome at 1 year of follow-up.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n CTRI\/2019\/11\/022088<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamacardio.2025.5057","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:30:31Z","timestamp":1770827431000},"page":"369","source":"Crossref","is-referenced-by-count":20,"title":["Ticagrelor vs Prasugrel in Patients With Diabetes and Multivessel Coronary Artery Disease"],"prefix":"10.1001","volume":"11","author":[{"given":"Sripal","family":"Bangalore","sequence":"first","affiliation":[{"name":"NYU Langone Health, NYU Grossman School of Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Sinha","sequence":"additional","affiliation":[{"name":"LPS Institute of Cardiology and Cardiac Surgery, Kanpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Adesh Institute of Medical Sciences and Research Hospital, Bhatinda, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Parida","sequence":"additional","affiliation":[{"name":"Healthworld Hospitals, Durgapur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Mody","sequence":"additional","affiliation":[{"name":"Mody Harvard Heart Institute & Research Centre-Krishna Super Specialty Hospital, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal","family":"Abhaichand","sequence":"additional","affiliation":[{"name":"G. Kuppuswami Naidu Memorial Hospital, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Banker","sequence":"additional","affiliation":[{"name":"Bankers Heart Institute, Vadodara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Khan","sequence":"additional","affiliation":[{"name":"Crescent Hospital and Heart Centre, Nagpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Kalyansundaram","sequence":"additional","affiliation":[{"name":"Promed Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraja","family":"Moorthy","sequence":"additional","affiliation":[{"name":"Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Indira Gandhi Medical College, Shimla, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishav","family":"Mohan","sequence":"additional","affiliation":[{"name":"Dayanand Medical College & Hospital, Ludhiana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaveesh","family":"Meel","sequence":"additional","affiliation":[{"name":"Heart & General Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Fortis Hospital, Bannerghatta Road, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Porwal","sequence":"additional","affiliation":[{"name":"KLES Dr Prabhakar Kore Hospital & Medical Research Centre, Belagavi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Bhagwat","sequence":"additional","affiliation":[{"name":"Kamalnayan Bajaj Hospital, Aurangabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charantharayail Gopalan","family":"Bahuleyan","sequence":"additional","affiliation":[{"name":"Ananthapuri Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Davidson","sequence":"additional","affiliation":[{"name":"Caritas Hospital and Institute of Health Science, Kottayam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudheer","family":"Koganti","sequence":"additional","affiliation":[{"name":"Citizens Specialty Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Garsa","sequence":"additional","affiliation":[{"name":"Danashivam Hospital, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla","family":"Kerkar","sequence":"additional","affiliation":[{"name":"King Edward Memorial Hospital, Parel, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopala Krishna","family":"Koduru","sequence":"additional","affiliation":[{"name":"Aayush Hospitals, Sri Ramachandra Nagar, Vijayawada, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Sreedharan","sequence":"additional","affiliation":[{"name":"Noorul Islam Institute of Medical Science and Research Foundation, Medicity, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Jagtap","sequence":"additional","affiliation":[{"name":"Viveka Super Specialty Hospital, Nagpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Manohar","sequence":"additional","affiliation":[{"name":"Fortis Malar Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Research, Batra Hospital and Medical Research Center, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarshini","family":"Arambam","sequence":"additional","affiliation":[{"name":"Batra Hospital and Medical Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagma","family":"Khan","sequence":"additional","affiliation":[{"name":"Batra Hospital and Medical Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Koul","sequence":"additional","affiliation":[{"name":"Batra Hospital and Medical Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnankutty","family":"Sudhir","sequence":"additional","affiliation":[{"name":"Sahajanand Medical Technologies Limited, Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra","family":"Kaul","sequence":"additional","affiliation":[{"name":"Batra Hospital and Medical Research Centre, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TUXEDO-2 India Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rajesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Sharad","family":"Chandra","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Neil","family":"Bordoloi","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Dilip","family":"Kumar","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Sarat","family":"Chandra","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Sengottuvelu","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rajneesh","family":"Kapoor","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rituparno","family":"Baruah","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Raja Ram","family":"Mantri","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Ravikant","family":"Patil","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Yashpaul","family":"Sharma","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Deepesh Kumar","family":"Agrawal","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Polavarapu Veera Raghava","family":"Sharma","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rajeev","family":"Garg","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Praveen","family":"Chandra","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Prakash","family":"Ajmera","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Jaspal","family":"Arneja","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Subhash","family":"Chandra","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Nityanand","family":"Tripathi","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Aditya","family":"Batra","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Dhiman","family":"Kahali","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Shuvanan","family":"Ray","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Jay M","family":"Shah","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Vishal Anand","family":"Poptani","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Jaskaran Singh","family":"Dugal","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Anil","family":"Potdar","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Pravin Kumar","family":"Goel","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rishi","family":"Sethi","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Praveen","family":"SV","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Arijit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Keshava","family":"Ramaiah","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rony","family":"Mathew","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"John F","family":"John","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Nirav","family":"Bhalani","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rajesh","family":"Badani","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Balbir","family":"Singh","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"C","family":"Raghu","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Ramesh","family":"Natarajan","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Narsimha","family":"Pai","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Dheeraj","family":"Gandotra","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Sai","family":"Sudhakar","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Prashant Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Sanjay","family":"Tyagi","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Rakesh Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Dr","given":"Johann","family":"Christopher","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Mr","given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Ms","given":"Yumnam Diana","family":"Devi","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Ms","given":"Siddhi","family":"Maheswari","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Ms","given":"Dushyant","family":"Sharma","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Ms","given":"Anjali","family":"Bhatt","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Ms","given":"Tamanpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"for the TUXEDO-2 India Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"19","key":"hoi250077r1","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/j.jacc.2020.03.008","article-title":"Ticagrelor with or without aspirin in high-risk patients with diabetes mellitus undergoing percutaneous coronary intervention.","volume":"75","author":"Angiolillo","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"14","key":"hoi250077r2","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1136\/heartjnl-2020-318694","article-title":"Prasugrel vs ticagrelor in patients with myocardial infarction undergoing percutaneous coronary intervention.","volume":"107","author":"Venetsanos","year":"2021","journal-title":"Heart"},{"issue":"1","key":"hoi250077r3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12959-023-00559-3","article-title":"Progress in the clinical effects and adverse reactions of ticagrelor.","volume":"22","author":"Wei","year":"2024","journal-title":"Thromb J"},{"issue":"1","key":"hoi250077r4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000520673","article-title":"Comparison of prasugrel and ticagrelor for patients with acute coronary syndrome: a systematic review and meta-analysis.","volume":"147","author":"Fong","year":"2022","journal-title":"Cardiology"},{"issue":"12","key":"hoi250077r5","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1002\/pds.4668","article-title":"Comparative effectiveness and safety of antiplatelet drugs in patients with diabetes mellitus and acute coronary syndrome.","volume":"27","author":"Spoendlin","year":"2018","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"5","key":"hoi250077r6","doi-asserted-by":"publisher","first-page":"594","DOI":"10.21037\/cdt.2018.05.09","article-title":"Diabetes and antiplatelet therapy: from bench to bedside.","volume":"8","author":"Rivas Rios","year":"2018","journal-title":"Cardiovasc Diagn Ther"},{"issue":"16","key":"hoi250077r7","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1056\/NEJMoa1908973","article-title":"Ticagrelor or prasugrel in patients with acute coronary syndromes.","volume":"381","author":"Sch\u00fcpke","year":"2019","journal-title":"N Engl J Med"},{"issue":"19","key":"hoi250077r8","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1016\/j.jcin.2020.07.032","article-title":"Ticagrelor or prasugrel in patients with acute coronary syndromes and diabetes mellitus.","volume":"13","author":"Ndrepepa","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"hoi250077r9","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ahj.2022.10.082","article-title":"Rationale and design of the TUXEDO-2 India study: Ultrathin Strut Supraflex Cruz vs Xience in a Diabetic Population With Multivessel Disease 2.","volume":"256","author":"Kaul","year":"2023","journal-title":"Am Heart J"},{"issue":"20","key":"hoi250077r10","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1161\/CIRCULATIONAHA.117.031164","article-title":"International expert consensus on switching platelet P2Y12 receptor\u2013inhibiting therapies.","volume":"136","author":"Angiolillo","year":"2017","journal-title":"Circulation"},{"issue":"23","key":"hoi250077r11","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1093\/eurheartj\/ehy223","article-title":"Standardized end point definitions for coronary intervention trials: the Academic Research Consortium 2 consensus document.","volume":"39","author":"Garcia-Garcia","year":"2018","journal-title":"Eur Heart J"},{"issue":"23","key":"hoi250077r12","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium.","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"issue":"16","key":"hoi250077r13","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction.","volume":"60","author":"Thygesen","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"31","key":"hoi250077r14","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1093\/eurheartj\/ehz372","article-title":"Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk.","volume":"40","author":"Urban","year":"2019","journal-title":"Eur Heart J"},{"issue":"11","key":"hoi250077r15","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Ticagrelor vs clopidogrel in patients with acute coronary syndromes.","volume":"361","author":"Wallentin","year":"2009","journal-title":"N Engl J Med"},{"issue":"16","key":"hoi250077r16","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1161\/CIRCULATIONAHA.108.791061","article-title":"Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel\u2014Thrombolysis in Myocardial Infarction 38.","volume":"118","author":"Wiviott","year":"2008","journal-title":"Circulation"},{"issue":"24","key":"hoi250077r17","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1093\/eurheartj\/ehq325","article-title":"Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the Platelet Inhibition and Patient Outcomes (PLATO) trial.","volume":"31","author":"James","year":"2010","journal-title":"Eur Heart J"},{"issue":"13","key":"hoi250077r18","doi-asserted-by":"publisher","first-page":"e771","DOI":"10.1161\/CIR.0000000000001309","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Joint committee on clinical practice guidelines.","volume":"151","author":"Rao","year":"2025","journal-title":"Circulation"},{"issue":"38","key":"hoi250077r19","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC guidelines for the management of acute coronary syndromes.","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"issue":"11","key":"hoi250077r20","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1161\/CIRCULATIONAHA.116.023402","article-title":"Pharmacodynamic comparison of prasugrel vs ticagrelor in patients with type 2 diabetes mellitus and coronary artery disease: the OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus) 4 study.","volume":"134","author":"Franchi","year":"2016","journal-title":"Circulation"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2844869\/jamacardiology_bangalore_2026_oi_250077_1775567394.80321.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:00:59Z","timestamp":1775660459000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2844869"}},"subtitle":["The TUXEDO-2 Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2025.5057","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}