{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T08:41:35Z","timestamp":1794472895832,"version":"4.9.1"},"reference-count":22,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"\n Importance<\/jats:title>\n Anterior acute myocardial infarction is associated with increased risk of left ventricular (LV) thrombus. The benefit and risk of adding an oral anticoagulant to dual antiplatelet therapy (DAPT) in preventing LV thrombus remain uncertain.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine whether the addition of low-dose rivaroxaban to DAPT reduces the incidence of LV thrombus at 1 month in patients with anterior ST-segment elevation myocardial infarction (STEMI).<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This multicenter, open-label, blinded\u2013end point randomized clinical trial was performed in 29 centers in France. The trial was nested in the ongoing FRENCHIE (French Cohort of Myocardial Infarction Evaluation) registry. Between October 2021 and January 2023, patients with anterior STEMI were enrolled. The last date of participant follow-up was in March 2023. Data analysis was performed from September 2024 to July 2025.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Patients were randomized to receive either DAPT plus rivaroxaban, 2.5 mg, twice daily for 4 weeks (n\u2009=\u2009283) or DAPT alone (aspirin \u2264100 mg per day and either clopidogrel, 75 mg per day, or ticagrelor, 90 mg twice a day [n\u2009=\u2009277]), as soon as possible following completion of the initial percutaneous coronary intervention or angiography procedure.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary end point was presence of LV thrombus on contrast-enhanced cardiac magnetic resonance imaging at 1 month.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 560 patients with anterior STEMI enrolled (mean [SD] age, 61.1 [11.6] years; 121 female patients [21.6%]), LV thrombus was detected in 38 patients (13.7%) receiving rivaroxaban and 47 patients (16.6%) with DAPT alone (difference, \u22122.9%; 95% CI, \u22128.9% to 3.2%;\n P<\/jats:italic>\n \u2009=\u2009.34). No difference was observed between the 2 groups regarding the largest diameter of LV thrombus or the incidence of major adverse cardiovascular events. The incidence of major bleeding events (Bleeding Academic Research Consortium [BARC] \u2265type 2) was also comparable (4 [1.5%] with DAPT plus rivaroxaban vs 2 [0.7%] with DAPT alone; difference, 0.7%; 95% CI, \u22121.3% to 3.1%), whereas minor bleeding events (BARC type 1) occurred more frequently in the DAPT plus rivaroxaban group (45 [16.4%] vs 20 [7.2%]; difference, 9.3%; 95% CI, 3.6%-14.8%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this multicenter randomized clinical trial among patients with anterior STEMI, the addition of low-dose rivaroxaban to DAPT did not demonstrate a statistically significant reduction in LV thrombus formation at 1 month but did increase minor bleeding. Given the limited power of the study, these findings should be interpreted with caution, as a modest effect cannot be excluded.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT05077683<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamacardio.2026.0026","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:30:30Z","timestamp":1772037030000},"page":"323","source":"Crossref","is-referenced-by-count":7,"title":["Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction"],"prefix":"10.1001","volume":"11","author":[{"given":"Etienne","family":"Puymirat","sequence":"first","affiliation":[{"name":"Department of Cardiology, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Paris, France"},{"name":"Paris\u2013Cardiovascular Research Center (PARCC), Universit\u00e9 de Paris Cit\u00e9, Paris, France"},{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Soulat","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Europ\u00e9en Georges-Pompidou, AP-HP, Paris, France"},{"name":"PARCC, Universit\u00e9 Paris Cit\u00e9, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Lattuca","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Cardiology, N\u00eemes University Hospital, ACTION Study Group, Montpellier University, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bouleti","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Cardiology, University Hospital of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Delarche","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier de Pau, Pau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"PhyMedExp, Cardiology Department, University of Montpellier, INSERM U1046, CNRS UMR, 9214, INI-CRT, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[{"name":"PEC2, EA 7460, University of Bourgogne Franche-Comt\u00e9, Dijon, France"},{"name":"Cardiology Department, University Hospital Centre of Dijon Bourgogne, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Bression","sequence":"additional","affiliation":[{"name":"Cardiology Division, University Hospital of Mulhouse, H\u00f4pital Emile Muller, Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Combaret","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU Clermont-Ferrand, Clermont-Ferrand, France"},{"name":"Institut Pascal, Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Gerbaud","sequence":"additional","affiliation":[{"name":"Cardiology Intensive Care Unit and Interventional Cardiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, Pessac, France"},{"name":"Bordeaux Cardiothoracic Research Center, U1045, Bordeaux University, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Lhermusier","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit, Department of Cardiology, Rangueil University Hospital, Toulouse, France"},{"name":"Medical School, Toulouse III Paul Sabatier University, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Biere","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Angers, Angers, France"},{"name":"UMR CNRS 6015-INSERM U1083, Institut Mitovasc, University of Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dubreuil","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit, Department of Cardiology, H\u00f4pital Saint-Joseph Saint-Luc, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Mousseaux","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Europ\u00e9en Georges-Pompidou, AP-HP, Paris, France"},{"name":"PARCC, Universit\u00e9 Paris Cit\u00e9, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Laboratory for Vascular Translational Science, French Alliance for Cardiovascular Trials, INSERM U1148, H\u00f4pital Bichat, AP-HP, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cayla","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Cardiology, N\u00eemes University Hospital, ACTION Study Group, Montpellier University, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lemesle","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille, Lille, France"},{"name":"Heart and Lung Institute, Institut Pasteur of Lille, University Hospital of Lille, INSERM U1011, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Silvain","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, INSERM UMRS 1166, ACTION Study Group, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Guillaume","family":"Dillinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, INSERM MASCOT-UMRS 942, H\u00f4pital Lariboisi\u00e8re, AP-HP, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Georges","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Cardiologie Interventionnelle, Centre Hospitalier de Versailles, H\u00f4pital Andr\u00e9 Mignot, Le Chesnay-Rocquencourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Ducrocq","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Cardiology Department, H\u00f4pital Bichat, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Genet","sequence":"additional","affiliation":[{"name":"Cardiology Department, H\u00f4pital Trousseau, Centre Hospitalier R\u00e9gional Universitaire de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Morelle","sequence":"additional","affiliation":[{"name":"Clinique St Martin, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, INSERM UMRS 1166, ACTION Study Group, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Berard","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Clinical Pharmacology and Unit\u00e9 de Recherche Clinique (URCEST), H\u00f4pital Saint Antoine, AP-HP, Paris, France"},{"name":"INSERM U-698, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rousseau","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Clinical Pharmacology and Unit\u00e9 de Recherche Clinique (URCEST), H\u00f4pital Saint Antoine, AP-HP, Paris, France"},{"name":"INSERM U-698, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Soen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Unit\u00e9 de Recherche Clinique (URCEST), H\u00f4pital Saint Antoine, AP-HP, Paris, France"},{"name":"INSERM U-698, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabassome","family":"Simon","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Clinical Pharmacology and Unit\u00e9 de Recherche Clinique (URCEST), H\u00f4pital Saint Antoine, AP-HP, Paris, France"},{"name":"INSERM U-698, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Danchin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Paris, France"},{"name":"Paris\u2013Cardiovascular Research Center (PARCC), Universit\u00e9 de Paris Cit\u00e9, Paris, France"},{"name":"French Alliance for Cardiovascular Trials (FACT), Paris, France"},{"name":"Department of Cardiology, Saint Joseph Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"APERITIF study investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Prieur","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Range","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Gallet","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Baronne Rochette","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheikh","family":"Khelifa","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bonello","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cuisset","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Saib","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Varenne","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Auffret","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Ferrari","sequence":"additional","affiliation":[{"name":"for the APERITIF study investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"7","key":"hoi260001r1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1001\/jamacardio.2018.1086","article-title":"Left ventricular thrombus after acute myocardial infarction: screening, prevention, and treatment.","volume":"3","author":"McCarthy","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"3","key":"hoi260001r2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/eurheartj\/ehx551","article-title":"Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction.","volume":"39","author":"Maniwa","year":"2018","journal-title":"Eur Heart J"},{"issue":"13","key":"hoi260001r3","doi-asserted-by":"publisher","first-page":"e771","DOI":"10.1161\/CIR.0000000000001309","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines.","volume":"151","author":"Rao","year":"2025","journal-title":"Circulation"},{"issue":"2","key":"hoi260001r4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation of the European Society of Cardiology (ESC).","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"2","key":"hoi260001r5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jacc.2008.03.041","article-title":"Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction.","volume":"52","author":"Weinsaft","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"hoi260001r6","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1016\/j.ejrad.2012.06.029","article-title":"Left ventricular thrombus formation after acute myocardial infarction as assessed by cardiovascular magnetic resonance imaging.","volume":"81","author":"Delewi","year":"2012","journal-title":"Eur J Radiol"},{"issue":"1","key":"hoi260001r7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ahj.2005.08.021","article-title":"Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validation.","volume":"152","author":"Srichai","year":"2006","journal-title":"Am Heart J"},{"key":"hoi260001r8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ijcard.2019.04.010","article-title":"The effect of ticagrelor based dual antiplatelet therapy on development of late left ventricular thrombus after acute anterior ST elevation myocardial infarction.","volume":"287","author":"Altintas","year":"2019","journal-title":"Int J Cardiol"},{"issue":"38","key":"hoi260001r9","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC guidelines for the management of acute coronary syndromes.","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"issue":"15","key":"hoi260001r10","doi-asserted-by":"publisher","first-page":"e205","DOI":"10.1161\/CIR.0000000000001092","article-title":"Management of patients at risk for and with left ventricular thrombus: a scientific statement from the American Heart Association.","volume":"146","author":"Levine","year":"2022","journal-title":"Circulation"},{"issue":"8","key":"hoi260001r11","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJMoa1105819","article-title":"Apixaban with antiplatelet therapy after acute coronary syndrome.","volume":"365","author":"Alexander","year":"2011","journal-title":"N Engl J Med"},{"issue":"18","key":"hoi260001r12","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/j.jacc.2013.01.066","article-title":"Rivaroxaban in patients stabilized after a ST-segment elevation myocardial infarction: results from the ATLAS ACS-2-TIMI-51 trial (Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction-51).","volume":"61","author":"Mega","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"hoi260001r13","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.jcin.2022.01.285","article-title":"Prophylactic rivaroxaban therapy for left ventricular thrombus after anterior ST-segment elevation myocardial infarction.","volume":"15","author":"Zhang","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"hoi260001r14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ahj.2023.09.005","article-title":"Rationale and design of the direct oral anticoagulants for prevention of left ventricular thrombus after anterior acute myocardial infarction (APERITIF) trial.","volume":"266","author":"Puymirat","year":"2023","journal-title":"Am Heart J"},{"issue":"6-7","key":"hoi260001r15","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.acvd.2024.04.004","article-title":"Rationale and design of the French cohort of myocardial infarction evaluation (FRENCHIE) study.","volume":"117","author":"Gautier","year":"2024","journal-title":"Arch Cardiovasc Dis"},{"issue":"1","key":"hoi260001r16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1532-429X-15-91","article-title":"Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update.","volume":"15","author":"Kramer","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"issue":"1","key":"hoi260001r17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1532-429X-15-35","article-title":"Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing.","volume":"15","author":"Schulz-Menger","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"issue":"5","key":"hoi260001r18","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jcmg.2015.06.017","article-title":"Echocardiographic algorithm for post-myocardial infarction LV thrombus: a gatekeeper for thrombus evaluation by delayed enhancement CMR.","volume":"9","author":"Weinsaft","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"hoi260001r19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/01.CIR.76.1.142","article-title":"Thrombolysis in myocardial infarction (TIMI) trial, phase i: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. clinical findings through hospital discharge.","volume":"76","author":"Chesebro","year":"1987","journal-title":"Circulation"},{"issue":"23","key":"hoi260001r20","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium.","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"hoi260001r21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12968-018-0494-3","article-title":"Incidence and predictors of left ventricular thrombus by cardiovascular magnetic resonance in acute ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: a meta-analysis.","volume":"20","author":"Bulluck","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"issue":"7","key":"hoi260001r22","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association.","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke"}],"container-title":["JAMA Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/articlepdf\/2845590\/jamacardiology_puymirat_2026_oi_260001_1775567389.40294.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:00:57Z","timestamp":1775660457000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamacardiology\/fullarticle\/2845590"}},"subtitle":["The APERITIF Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamacardio.2026.0026","relation":{},"ISSN":["2380-6583"],"issn-type":[{"value":"2380-6583","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}