{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:45:25Z","timestamp":1793090725177,"version":"4.5.0"},"reference-count":22,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Cardiol"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"\n Importance<\/jats:title>\n As transcatheter aortic valve replacement (TAVR) is considered for younger and lower-risk populations, the durability of bioprosthetic valves is increasingly important. Limited data exist on long-term (7 years and beyond) valve durability.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To report 7-year valve durability outcomes for low-risk patients with symptomatic severe aortic stenosis treated with TAVR vs surgery.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Between March 2016 and October 2017, a total of 1000 patients were enrolled at 71 centers in the US and Canada and randomized to undergo TAVR vs surgery. The patient population for the present analysis consisted of all patients who underwent valve implantation (495 with TAVR and 453 with surgery). The last 7-year follow-up occurred in March 2025.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Patients were randomized to balloon-expandable TAVR with the SAPIEN 3 valve or surgery with any commercially available valve.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcomes of this analysis were stage 2 or 3 bioprosthetic valve dysfunction (BVD) related to structural valve deterioration (SVD), thrombosis, or endocarditis; all-cause bioprosthetic valve failure (BVF); BVF related to SVD; and aortic valve reintervention at 7 years. Analyses are presented as cumulative incidence rates with death as a competing risk.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean (SD) age of the study population was 73.5 (6.0) years, and 657 participants (69.3%) were male. Of 671 patients who were still alive and enrolled in the study at 7-year follow-up, 537 (80.0%) were available for echocardiographic analysis. Cumulative incidence rates of stage 2 or 3 SVD-related BVD (7.3% vs 7.6%; hazard ratio [HR], 0.96; 95% CI, 0.59-1.57;\n P<\/jats:italic>\n \u2009=\u2009.88), all-cause BVF (6.9% vs 7.5%; HR, 0.91; 95% CI, 0.55-1.49;\n P<\/jats:italic>\n \u2009=\u2009.69), SVD-related BVF (3.9% vs 5.3%; HR, 0.72; 95% CI, 0.39-1.36;\n P<\/jats:italic>\n \u2009=\u2009.31), and valve reintervention (6.0% vs 5.5%; HR, 1.09; 95% CI, 0.62-1.90;\n P<\/jats:italic>\n \u2009=\u2009.77) were low and similar for TAVR and surgery, respectively. Stage 2 or 3 thrombosis-related BVD (subclinical and clinical) occurred more frequently with TAVR (5.2% vs 0.9%; HR, 5.52; 95% CI, 1.92-15.85;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001), although most events occurred within 3 years and few progressed to BVF. Rates of stage 2 or 3 endocarditis-related BVD were also low and similar (0.4% in the TAVR group vs 0.5% in the surgery group; HR, 0.85; 95% CI, 0.12-6.07;\n P<\/jats:italic>\n \u2009=\u2009.87). The proportion of patients alive and free of all-cause BVF was 73.4% (331\/451) with TAVR vs 74.8% (288\/385) with surgery (\n P<\/jats:italic>\n \u2009=\u2009.69).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this ad hoc analysis of a randomized clinical trial among low-risk patients with symptomatic severe aortic stenosis randomized to TAVR or surgery, both TAVR and surgery demonstrated comparable and sustained valve durability, with low and similar rates of SVD, all-cause BVF, and reintervention through 7 years. These findings may inform discussions of valve replacement strategies.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT02675114<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamacardio.2026.2299","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:32:09Z","timestamp":1782315129000},"page":"747","source":"Crossref","is-referenced-by-count":8,"title":["Seven-Year Valve Durability With Transcatheter or Surgical Aortic Valve Replacement"],"prefix":"10.1001","volume":"11","author":[{"given":"Julien","family":"Ternacle","sequence":"first","affiliation":[{"name":"Haut-Leveque Cardiology Hospital, Bordeaux University, Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, New York"},{"name":"Columbia University Irving Medical Center\/New York-Presbyterian Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain"},{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Alperi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain"},{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonela","family":"Zanuttini","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Th\u00e9ron","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Department of Cardiology, Assistance Publique, H\u00f4pitaux de Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellaziz","family":"Dahou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Geisinger Medical Center and Geisinger College of Health Sciences, Wilkes-Barre, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Cristell","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Woods","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Guzzetti","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Department of Cardiology, Centre hospitalier affili\u00e9 universitaire regional, Trois Rivi\u00e8res, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Yves","family":"Turgeon","sequence":"additional","affiliation":[{"name":"Institut 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