{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:42:25Z","timestamp":1792111345650,"version":"4.4.0"},"reference-count":14,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2020,2,1]]},"DOI":"10.1001\/jamadermatol.2019.3839","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T16:35:43Z","timestamp":1576082143000},"page":"186","source":"Crossref","is-referenced-by-count":61,"title":["Evaluating the Safety of Oral Propranolol Therapy in Patients With PHACE Syndrome"],"prefix":"10.1001","volume":"156","author":[{"given":"Gerilyn M.","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Stefanko","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Mathes","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine B.","family":"Puttgen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, John Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Dermatology, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha M.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lauren","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Northwestern University and Ann and Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois"},{"name":"Department of Dermatology, Northwestern University and Ann and Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.","family":"McCuaig","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte-Justine University Hospital Centre, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona J.","family":"Frieden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Hematology, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulalia","family":"Baselga","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Chamlin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Northwestern University and Ann and Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois"},{"name":"Department of Dermatology, Northwestern University and Ann and Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, Seattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Frommelt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Garzon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Horii","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Children\u2019s Mercy Hospital, Kansas City, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Klajn","sequence":"additional","affiliation":[{"name":"Department of Hematology, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Newell","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Children\u2019s Mercy Hospital, Kansas City, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry L.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nopper","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Children\u2019s Mercy Hospital, Kansas City, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Pediatrics, Sainte-Justine University Hospital Centre, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn H.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Drolet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee,"},{"name":"Department of Dermatology, University of Wisconsin\u2013Madison School of Medicine and Public Health, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"dbr190005r1","doi-asserted-by":"publisher","first-page":"e418","DOI":"10.1542\/peds.2009-3166","article-title":"Risk for PHACE syndrome in infants with large facial hemangiomas.","volume":"126","author":"Haggstrom","year":"2010","journal-title":"Pediatrics"},{"issue":"4","key":"dbr190005r2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0353","article-title":"Safety of oral propranolol for the treatment of infantile hemangioma: a systematic review.","volume":"138","author":"L\u00e9aute-Labr\u00e8ze","year":"2016","journal-title":"Pediatrics"},{"issue":"1","key":"dbr190005r3","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-3475","article-title":"Clinical practice guideline for the management of infantile hemangiomas.","volume":"143","author":"Krowchuk","year":"2019","journal-title":"Pediatrics"},{"key":"dbr190005r4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jpeds.2016.07.054","article-title":"PHACE syndrome: consensus-derived diagnosis and care recommendations.","volume":"178","author":"Garzon","year":"2016","journal-title":"J Pediatr"},{"issue":"6","key":"dbr190005r7","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1161\/STROKEAHA.112.650952","article-title":"Stroke in children with posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities (PHACE) syndrome: a systematic review of the literature.","volume":"43","author":"Siegel","year":"2012","journal-title":"Stroke"},{"issue":"6","key":"dbr190005r8","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1080\/09546634.2016.1277177","article-title":"Oral propranolol for infantile hemangiomas: a prospective study on the role of 48-hour Holter monitoring in additional safety assessment.","volume":"28","author":"Petrovic","year":"2017","journal-title":"J Dermatolog Treat"},{"issue":"11","key":"dbr190005r9","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1111\/jdv.2018.32.issue-11","article-title":"Safety profile during initiation of propranolol for treatment of infantile haemangiomas in an ambulatory day-care hospitalization setting.","volume":"32","author":"Fogel","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"dbr190005r10","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1038\/s41598-017-01321-2","article-title":"Safety and tolerance of propranolol in neonates with severe infantile hemangiomas: a prospective study.","volume":"7","author":"Ji","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"dbr190005r11","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/pde.2013.30.issue-5","article-title":"Twenty-four-hour hospitalization for patients initiating systemic propranolol therapy for infantile hemangiomas\u2014is it indicated?","volume":"30","author":"Liu","year":"2013","journal-title":"Pediatr Dermatol"},{"issue":"1-2","key":"dbr190005r12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000450755","article-title":"Cardiovascular profile of propranolol after multiple dosing in infantile hemangioma.","volume":"99","author":"Salice","year":"2017","journal-title":"Pharmacology"},{"issue":"1","key":"dbr190005r13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/pde.2013.30.issue-1","article-title":"Propranolol use in PHACE syndrome with cervical and intracranial arterial anomalies: collective experience in 32 infants.","volume":"30","author":"Metry","year":"2013","journal-title":"Pediatr Dermatol"},{"issue":"0","key":"dbr190005r14","article-title":"Systemic timolol exposure following topical application to infantile hemangiomas.","volume":"0","author":"Drolet","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"dbr190005r6","author":"Hansen","year":"2018"},{"key":"dbr190005r5","unstructured":"US Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf. Published November 27, 2017. Accessed November 4, 2019."}],"container-title":["JAMA Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/articlepdf\/2757271\/jamadermatology_olsen_2019_br_190005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T16:03:12Z","timestamp":1581523392000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2757271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,1]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamadermatol.2019.3839","relation":{},"ISSN":["2168-6068"],"issn-type":[{"value":"2168-6068","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,1]]}}}