{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:51:07Z","timestamp":1792601467888,"version":"4.5.0"},"reference-count":53,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2022,4,1]]},"DOI":"10.1001\/jamadermatol.2022.0036","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:07:59Z","timestamp":1646824079000},"page":"414","source":"Crossref","is-referenced-by-count":40,"title":["Spectrum of Nonkeratinocyte Skin Cancer Risk Among Solid Organ Transplant Recipients in the US"],"prefix":"10.1001","volume":"158","author":[{"given":"Michael R.","family":"Sargen","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth K.","family":"Cahoon","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Madeleine","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zeng","sequence":"additional","affiliation":[{"name":"North Dakota Statewide Cancer Registry, Grand Forks"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy R.","family":"Rees","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Iowa Cancer Registry, Department of Epidemiology, The University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Engels","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"17","key":"doi220004r1","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1001\/jama.2011.1592","article-title":"Spectrum of cancer risk among US solid organ transplant recipients.","volume":"306","author":"Engels","year":"2011","journal-title":"JAMA"},{"issue":"9581","key":"doi220004r2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0140-6736(07)61050-2","article-title":"Incidence of cancers in people with HIV\/AIDS compared with immunosuppressed transplant recipients: a meta-analysis.","volume":"370","author":"Grulich","year":"2007","journal-title":"Lancet"},{"issue":"2","key":"doi220004r3","article-title":"Ambient ultraviolet radiation and sebaceous carcinoma incidence in the United States, 2000-2016.","volume":"4","author":"Sargen","year":"2020","journal-title":"J Natl Cancer Inst Cancer Spectr"},{"issue":"1-3","key":"doi220004r4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S1011-1344(01)00198-1","article-title":"The epidemiology of UV induced skin cancer.","volume":"63","author":"Armstrong","year":"2001","journal-title":"J Photochem Photobiol B"},{"issue":"7","key":"doi220004r5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/intimm\/dxz012","article-title":"Immunotherapy for skin cancer.","volume":"31","author":"Paulson","year":"2019","journal-title":"Int Immunol"},{"issue":"12","key":"doi220004r6","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1111\/ajt.13863","article-title":"Azathioprine and risk of skin cancer in organ transplant recipients: systematic review and meta-analysis.","volume":"16","author":"Jiyad","year":"2016","journal-title":"Am J Transplant"},{"issue":"9","key":"doi220004r7","doi-asserted-by":"publisher","first-page":"e580","DOI":"10.1016\/S2214-109X(16)30169-3","article-title":"Infection-related cancers: prioritising an important and eliminable contributor to the global cancer burden.","volume":"4","author":"Casper","year":"2016","journal-title":"Lancet Glob Health"},{"issue":"11","key":"doi220004r8","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1038\/jid.2015.312","article-title":"Melanoma risk and survival among organ transplant recipients.","volume":"135","author":"Robbins","year":"2015","journal-title":"J Invest Dermatol"},{"issue":"2","key":"doi220004r9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jaad.2010.11.063","article-title":"Skin cancer in solid organ transplant recipients: advances in therapy and management: part II: management of skin cancer in solid organ transplant recipients.","volume":"65","author":"O\u2019Reilly Zwald","year":"2011","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"doi220004r10","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/ijc.27765","article-title":"Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008: a Swedish population-based study.","volume":"132","author":"Krynitz","year":"2013","journal-title":"Int J Cancer"},{"issue":"2","key":"doi220004r11","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju382","article-title":"Risk of Merkel cell carcinoma after solid organ transplantation.","volume":"107","author":"Clarke","year":"2015","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"doi220004r12","first-page":"199","article-title":"Risk of rare cancers among solid organ transplant recipients.","volume":"113","author":"D\u2019Arcy","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"doi220004r13","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1001\/jamadermatol.2020.3111","article-title":"Sebaceous carcinoma incidence and survival among solid organ transplant recipients in the United States, 1987-2017.","volume":"156","author":"Sargen","year":"2020","journal-title":"JAMA Dermatol"},{"issue":"11","key":"doi220004r14","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1002\/ijc.v143.11","article-title":"Risk of Kaposi sarcoma after solid organ transplantation in the United States.","volume":"143","author":"Cahoon","year":"2018","journal-title":"Int J Cancer"},{"issue":"1","key":"doi220004r15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jaad.2016.02.1155","article-title":"Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013.","volume":"75","author":"Garrett","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"6382","key":"doi220004r16","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade.","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"issue":"9","key":"doi220004r17","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1111\/ajt.v20.9","article-title":"Efficacy and tolerance of immune checkpoint inhibitors in transplant patients with cancer: a systematic review.","volume":"20","author":"d\u2019Izarny-Gargas","year":"2020","journal-title":"Am J Transplant"},{"issue":"1","key":"doi220004r18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s40425-019-0585-1","article-title":"Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature.","volume":"7","author":"Abdel-Wahab","year":"2019","journal-title":"J Immunother Cancer"},{"issue":"3","key":"doi220004r19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/ijc.v146.3","article-title":"Survival among solid organ transplant recipients diagnosed with cancer compared to nontransplanted cancer patients: a nationwide study.","volume":"146","author":"Benoni","year":"2020","journal-title":"Int J Cancer"},{"issue":"15","key":"doi220004r20","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/cncr.32136","article-title":"Cancer-attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014.","volume":"125","author":"Noone","year":"2019","journal-title":"Cancer"},{"issue":"3","key":"doi220004r23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.annepidem.2007.10.005","article-title":"Underestimation of relative risks by standardized incidence ratios for AIDS-related cancers.","volume":"18","author":"Chaturvedi","year":"2008","journal-title":"Ann Epidemiol"},{"issue":"7","key":"doi220004r25","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1001\/jamadermatol.2020.1141","article-title":"Voriconazole and the risk of keratinocyte carcinomas among lung transplant recipients in the United States.","volume":"156","author":"D\u2019Arcy","year":"2020","journal-title":"JAMA Dermatol"},{"issue":"15","key":"doi220004r26","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1158\/0008-5472.CAN-16-3291","article-title":"Risk of second malignancies in solid organ transplant recipients who develop keratinocyte cancers.","volume":"77","author":"Zamoiski","year":"2017","journal-title":"Cancer Res"},{"issue":"1","key":"doi220004r27","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jid.2019.06.138","article-title":"Variation in cutaneous patterns of melanomagenesis according to germline CDKN2A\/CDK4 status in melanoma-prone families.","volume":"140","author":"Sargen","year":"2020","journal-title":"J Invest Dermatol"},{"issue":"8","key":"doi220004r28","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1111\/ajt.12281","article-title":"Primary cutaneous posttransplant lymphoproliferative disorders in solid organ transplant recipients: a multicenter European case series.","volume":"13","author":"Se\u00e7kin","year":"2013","journal-title":"Am J Transplant"},{"issue":"6","key":"doi220004r29","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1309\/LYXN3RGF7D7KPYG0","article-title":"T-cell and NK-cell posttransplantation lymphoproliferative disorders.","volume":"127","author":"Swerdlow","year":"2007","journal-title":"Am J Clin Pathol"},{"issue":"12","key":"doi220004r30","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/nrc2961","article-title":"Why do viruses cause cancer? Highlights of the first century of human tumour virology.","volume":"10","author":"Moore","year":"2010","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"doi220004r31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1158\/1078-0432.CCR-20-2473","article-title":"Sebaceous carcinoma epidemiology and genetics: emerging concepts and clinical implications for screening, prevention, and treatment.","volume":"27","author":"Sargen","year":"2021","journal-title":"Clin Cancer Res"},{"issue":"4","key":"doi220004r32","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1158\/1078-0432.CCR-18-1688","article-title":"Distinct biological types of ocular adnexal sebaceous carcinoma: HPV-driven and virus-negative tumors arise through nonoverlapping molecular-genetic alterations.","volume":"25","author":"Tetzlaff","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"3","key":"doi220004r33","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.jaci.2011.10.028","article-title":"Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency.","volume":"129","author":"Kesserwan","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"doi220004r34","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.jaad.2020.11.047","article-title":"Five-year survival in patients with nodular and superficial spreading melanomas in the US population.","volume":"84","author":"Allais","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"doi220004r35","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1001\/jamadermatol.2014.1348","article-title":"Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study.","volume":"150","author":"Thomas","year":"2014","journal-title":"JAMA Dermatol"},{"issue":"25","key":"doi220004r36","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1056\/NEJMc1713444","article-title":"Tumor mutational burden and response rate to PD-1 inhibition.","volume":"377","author":"Yarchoan","year":"2017","journal-title":"N Engl J Med"},{"issue":"3","key":"doi220004r37","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.annonc.2020.11.023","article-title":"The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin.","volume":"32","author":"Hernando","year":"2021","journal-title":"Ann Oncol"},{"issue":"20","key":"doi220004r38","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1182\/blood-2012-04-421412","article-title":"How I treat HHV8\/KSHV-related diseases in posttransplant patients.","volume":"120","author":"Riva","year":"2012","journal-title":"Blood"},{"issue":"6","key":"doi220004r39","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-236061","article-title":"Fatal donor-derived Kaposi sarcoma following liver transplantation.","volume":"14","author":"Copeland","year":"2021","journal-title":"BMJ Case Rep"},{"issue":"12","key":"doi220004r40","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/S1470-2045(09)70282-7","article-title":"Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study.","volume":"10","author":"Guiguet","year":"2009","journal-title":"Lancet Oncol"},{"issue":"5","key":"doi220004r41","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/TP.0000000000002147","article-title":"International liver transplantation society consensus statement on immunosuppression in liver transplant recipients.","volume":"102","author":"Charlton","year":"2018","journal-title":"Transplantation"},{"issue":"1","key":"doi220004r42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/phar.v41.1","article-title":"Immunosuppression trends in solid organ transplantation: the future of individualization, monitoring, and management.","volume":"41","author":"Pilch","year":"2021","journal-title":"Pharmacotherapy"},{"issue":"12","key":"doi220004r43","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/tri.v32.12","article-title":"Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines.","volume":"32","author":"Crow","year":"2019","journal-title":"Transpl Int"},{"issue":"37","key":"doi220004r44","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.1038\/s41388-021-01911-5","article-title":"Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma.","volume":"40","author":"Wang","year":"2021","journal-title":"Oncogene"},{"issue":"19","key":"doi220004r45","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.1158\/1078-0432.CCR-13-0142","article-title":"Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.","volume":"19","author":"Kwong","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"7","key":"doi220004r46","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1093\/infdis\/jiaa071","article-title":"Sirolimus and other mechanistic target of rapamycin inhibitors directly activate latent pathogenic human polyomavirus replication.","volume":"224","author":"Alvarez Orellana","year":"2021","journal-title":"J Infect Dis"},{"issue":"1","key":"doi220004r47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014535","article-title":"Rapamycin blocks production of KSHV\/HHV8: insights into the anti-tumor activity of an immunosuppressant drug.","volume":"6","author":"Nichols","year":"2011","journal-title":"PLoS One"},{"issue":"13","key":"doi220004r48","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa042831","article-title":"Sirolimus for Kaposi\u2019s sarcoma in renal-transplant recipients.","volume":"352","author":"Stallone","year":"2005","journal-title":"N Engl J Med"},{"issue":"1","key":"doi220004r49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/ajt.13978","article-title":"Cancer screening recommendations for solid organ transplant recipients: a systematic review of clinical practice guidelines.","volume":"17","author":"Acuna","year":"2017","journal-title":"Am J Transplant"},{"issue":"4","key":"doi220004r50","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1001\/jamaoncol.2015.5137","article-title":"Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada.","volume":"2","author":"Acuna","year":"2016","journal-title":"JAMA Oncol"},{"issue":"2","key":"doi220004r51","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/ajt.14966","article-title":"Improved keratinocyte carcinoma outcomes with annual dermatology assessment after solid organ transplantation: Population-based cohort study.","volume":"19","author":"Chan","year":"2019","journal-title":"Am J Transplant"},{"issue":"4","key":"doi220004r52","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1056\/NEJMoa1204166","article-title":"Sirolimus and secondary skin-cancer prevention in kidney transplantation.","volume":"367","author":"Euvrard","year":"2012","journal-title":"N Engl J Med"},{"issue":"1","key":"doi220004r53","doi-asserted-by":"publisher","first-page":"4712","DOI":"10.1038\/s41467-019-12628-1","article-title":"Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.","volume":"10","author":"Esfahani","year":"2019","journal-title":"Nat Commun"},{"key":"doi220004r21","unstructured":"National Cancer Institute. Transplant Cancer Match Study. Accessed January 28, 2022. https:\/\/transplantmatch.cancer.gov\/index.html"},{"key":"doi220004r22","unstructured":"Surveillance, Epidemiology, and End Results Program. Registry Groupings in SEER Data and Statistics. 2021. Accessed September 15, 2021. https:\/\/seer.cancer.gov\/registries\/terms.html"},{"key":"doi220004r24","unstructured":"National Aeronautics and Space Administration. TOMS Nimbus-7 Total Ozone Aerosol Index UV-Reflectivity UV-B Erythemal Irradiances Daily L3 Global 1 deg x 1.25 deg V008. Accessed January 28, 2022. https:\/\/disc.gsfc.nasa.gov\/datasets\/TOMSN7L3_008\/summary"}],"container-title":["JAMA Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/articlepdf\/2789437\/jamadermatology_sargen_2022_oi_220004_1649281883.09046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:39:36Z","timestamp":1700307576000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2789437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamadermatol.2022.0036","relation":{},"ISSN":["2168-6068"],"issn-type":[{"value":"2168-6068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}