{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:35:18Z","timestamp":1782776118554,"version":"3.54.5"},"reference-count":14,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec id=\"ab-dbr220023-4\"><jats:title>Importance<\/jats:title><jats:p>Cutaneous T-cell lymphoma (CTCL) is a group of rare, complex cutaneous malignant neoplasms associated with significant disease burden on patients and the health care system. Currently, the population of patients with CTCL admitted to the hospital remains largely uncharacterized and poorly understood.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr220023-5\"><jats:title>Objective<\/jats:title><jats:p>To characterize the clinical characteristics, course of hospitalization, and mortality outcomes of an inpatient CTCL cohort.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr220023-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This multicenter retrospective cohort study reviewed medical records for adult patients (age \u226518 years) with a CTCL diagnosis per National Comprehensive Cancer Network guidelines admitted for inpatient hospitalization at 5 US academic medical centers with inpatient dermatology consult services and CTCL clinics between August 2016 and August 2020.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr220023-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Patient demographics, clinical history and findings, hospitalization courses, and mortality outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr220023-8\"><jats:title>Results<\/jats:title><jats:p>A total of 79 hospitalized patients with CTCL were identified, including 52 (70.3%) men and 22 (29.7%) women, with a median (IQR) age at hospitalization of 62.9 (27-92) years. The majority of admitted patients with CTCL were White (65 patients [82.3%]), had disease classified as mycosis fungoides (48 patients [61.5%]), and had advanced-stage disease (\u2265IIB, 70 patients [89.7%]). Most hospitalizations were complicated by infection (45 patients [57.0%]) and required intravenous antibiotic therapy (45 patients [57.0%]). In-hospital mortality occurred in 6 patients (7.6%) and was associated with higher body mass index (36.5 vs 25.3), history of thromboembolic disease (50.0% vs 12.3%), and diagnosis of sepsis on admission (66.7% vs 20.5%). At 1-year postdischarge, 36 patients (49.3%) patients had died, and mortality was associated with history of solid organ cancers (27.8% vs 10.8%), wound care as the reason for dermatology consultation (58.3% vs 24.3%), and presence of large cell transformation (58.3% vs 22.9%).<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr220023-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The findings of this cohort study improve the understanding of hospitalized patients with CTCL and lend valuable insight into identifying factors associated with both in-hospital and long-term mortality outcomes. This refined understanding of the inpatient CTCL population provides a foundation for larger, more robust studies to identify causal risk factors associated with mortality, development of prognostic scoring systems to estimate the probability of hospital mortality. Overall, the findings may prompt physicians caring for patients with CTCL to implement preventive strategies to diminish hospitalization and improve clinical management across this unique disease spectrum.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2022.5740","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T16:00:39Z","timestamp":1672848039000},"page":"192","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics and Outcomes for Hospitalized Patients With Cutaneous T-Cell Lymphoma"],"prefix":"10.1001","volume":"159","author":[{"given":"George","family":"Glinos","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery, USF Health Morsani College of Medicine, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery, USF Health Morsani College of Medicine, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Nosewicz","sequence":"additional","affiliation":[{"name":"Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Cutaneous Oncology Program, H. Lee Moffitt Cancer Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Kaffenberger","sequence":"additional","affiliation":[{"name":"Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Querfeld","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michi M.","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomir","family":"Sokol","sequence":"additional","affiliation":[{"name":"Malignant Hematology Program, H. Lee Moffitt Cancer Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Zain","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambuj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Medicine and Health Outcomes Research, University of South Florida, Tampa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Seminario-Vidal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery, USF Health Morsani College of Medicine, Tampa, Florida"},{"name":"Cutaneous Oncology Program, H. 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