{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:55:46Z","timestamp":1790733346585,"version":"4.1.0"},"reference-count":34,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:sec id=\"ab-dcs230001-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Therapy for advanced melanoma has transformed during the past decade, but early detection and prognostic assessment of cutaneous melanoma (CM) remain paramount goals. Best practices for screening and use of pigmented lesion evaluation tools and gene expression profile (GEP) testing in CM remain to be defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-dcs230001-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide consensus recommendations on optimal screening practices and prebiopsy diagnostic, postbiopsy diagnostic, and prognostic assessment of CM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-dcs230001-6\">\n                    <jats:title>Evidence Review<\/jats:title>\n                    <jats:p>Case scenarios were interrogated using a modified Delphi consensus method. Melanoma panelists (n\u2009=\u200960) were invited to vote on hypothetical scenarios via an emailed survey (n\u2009=\u200942), which was followed by a consensus conference (n\u2009=\u200951) that reviewed the literature and the rationale for survey answers. Panelists participated in a follow-up survey for final recommendations on the scenarios (n\u2009=\u200945).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-dcs230001-7\">\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The panelists reached consensus (\u226570% agreement) in supporting a risk-stratified approach to melanoma screening in clinical settings and public screening events, screening personnel recommendations (self\/partner, primary care provider, general dermatologist, and pigmented lesion expert), screening intervals, and acceptable appointment wait times. Participants also reached consensus that visual and dermoscopic examination are sufficient for evaluation and follow-up of melanocytic skin lesions deemed innocuous. The panelists reached consensus on interpreting reflectance confocal microscopy and some but not all results from epidermal tape stripping, but they did not reach consensus on use of certain pigmented lesion evaluation tools, such as electrical impedance spectroscopy. Regarding GEP scores, the panelists reached consensus that a low-risk prognostic GEP score should not outweigh concerning histologic features when selecting patients to undergo sentinel lymph node biopsy but did not reach consensus on imaging recommendations in the setting of a high-risk prognostic GEP score and low-risk histology and\/or negative nodal status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-dcs230001-8\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>For this consensus statement, panelists reached consensus on aspects of a risk-stratified approach to melanoma screening and follow-up as well as use of visual examination and dermoscopy. These findings support a practical approach to diagnosing and evaluating CM. Panelists did not reach consensus on a clearly defined role for GEP testing in clinical decision-making, citing the need for additional studies to establish the clinical use of existing GEP assays.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.0127","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T11:12:38Z","timestamp":1678878758000},"page":"545","source":"Crossref","is-referenced-by-count":40,"title":["Early Detection and Prognostic Assessment of Cutaneous Melanoma"],"prefix":"10.1001","volume":"159","author":[{"given":"Mohammed","family":"Kashani-Sabet","sequence":"first","affiliation":[{"name":"Center for Melanoma Research and Treatment, California Pacific Medical Center Research Institute, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancy A.","family":"Leachman","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Family Medicine, Knight Cancer Institute, Oregon Health & Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Stein","sequence":"additional","affiliation":[{"name":"Ronald O. 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