{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T09:55:09Z","timestamp":1793613309700,"version":"4.5.0"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:sec><jats:title>Importance<\/jats:title><jats:p>Topical vitamin D analogues are routine treatment for psoriasis, but the effect of oral supplementation has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effect of vitamin D supplementation on psoriasis severity throughout the winter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This randomized, double-blind placebo-controlled clinical trial with 2 parallel groups was performed through 2 winter seasons (2017 to 2018 and 2018 to 2019). Randomization was computer generated. All participants, health care clinicians, and outcome assessors were masked to group assignment. Each participant was followed for 4 months. The presented analyses were conducted in May 2022. The trial was conducted at the clinical research unit of the University Hospital of North Norway (Troms\u00f8; Norway). Adults from the general population in Troms\u00f8 with active plaque psoriasis and 25-hydroxyvitamin D (25[OH]D) levels of less than 24 ng\/mL (to convert to nmol\/L, multiply by 2.496) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Vitamin D (cholecalciferol, 100\u202f000 IU, loading dose, followed by 20\u202f000 IU\/week) or placebo for 4 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes and Measures<\/jats:title><jats:p>Psoriasis Area Severity Index (PASI) (primary outcome), Physician Global Assessment, self-administered PASI, and Dermatology Life Quality Index scores (secondary outcomes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 122 participants (46 women [37.7%]; mean [SD] age, 53.6 [10.0] years; mean [SD] PASI score, 3.1 [2.0]; mean [SD] serum 25(OH)D, 14.9 [3.9] ng\/mL) were included. Of these, 60 (49.2%) were randomized to the vitamin D group and 62 (50.8%) to the placebo group. A total of 120 participants (59 vitamin D [49.2%]\/61 placebo [51.8%]) completed the study. By completion, mean (SD) 25(OH)D levels were 29.7 (5.2) ng\/mL (vitamin D) and 12.0 (3.8) ng\/mL (placebo). There was no significant difference in change in PASI score between the groups (adjusted difference, 0.11; 95% CI, \u22120.23 to 0.45). There was no significant difference in change in Physician Global Assessment score  (adjusted odds ratio, 0.66; 95% CI, 0.27-1.63), self-administered PASI (adjusted difference, \u22120.60; 95% CI, \u22121.76 to 0.55) or Dermatology Life Quality Index (adjusted difference, \u22120.86; 95% CI, \u22121.9 to 0.19) between the groups. No adverse effects of the intervention were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Relevance<\/jats:title><jats:p>The results of this randomized clinical trial showed that vitamin D supplementation did not affect psoriasis severity. Low baseline severity scores may explain the lack of measurable effect. Levels of 25(OH)D in the intervention group increased to a less-than-expected degree based on previous experimental data from the same source population, and this may have affected the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03334136\">NCT03334136<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.0357","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T17:19:10Z","timestamp":1680110350000},"page":"518","source":"Crossref","is-referenced-by-count":30,"title":["Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D 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