{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:55:08Z","timestamp":1783734908999,"version":"3.55.0"},"reference-count":15,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:sec id=\"ab-dbr230004-4\"><jats:title>Importance<\/jats:title><jats:p>Keratinocyte carcinomas are the most common cancers in the US. However, keratinocyte carcinomas are not included in US national cancer registries, and information on the anatomic locations of keratinocyte carcinomas is lacking.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230004-5\"><jats:title>Objective<\/jats:title><jats:p>To investigate the anatomic location of keratinocyte carcinomas in the US using a large claims data set.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230004-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>We performed a cohort study using a deidentified, random sample of 4\u202f999\u202f999 fee-for-service Medicare beneficiaries aged 65 years or older (2009-2018).<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230004-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Proportion of procedurally treated keratinocyte carcinomas at each anatomic location, identified by linking diagnosis and treatment codes.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230004-8\"><jats:title>Results<\/jats:title><jats:p>A total of 2\u202f415\u202f514 keratinocyte carcinomas were identified in 792\u202f393 beneficiaries. The mean (SD) age was 76.6 (8.1) years, 410\u202f364 (51.8%) were women, and 96.7% were White. Of the 2\u202f415\u202f514 keratinocyte carcinomas, 796\u202f542 could be subtyped into basal cell carcinoma (33.0%), 927\u202f984 into squamous cell carcinoma (38.4%), and 690\u202f988 (28.6%) could not be subtyped. The most common location of squamous cell carcinomas was the head and\/or neck (44.3%) followed by upper limbs (26.7%). The most common location of basal cell carcinomas was head and\/or neck (63.8%), followed by trunk (14.9%). In women, keratinocyte carcinomas were most common on the head and\/or neck (47.3%) followed by upper and lower limb (18.5% and 16.6%, respectively). In men, keratinocyte carcinomas were most common on the head and\/or neck (58.7%) followed by upper limb and trunk (17.3% and 11.4%, respectively).<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230004-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The results of this large Medicare cohort study highlight the anatomic locations of keratinocyte carcinomas over recent years and show the predominance of lesions occurring at head and\/or neck anatomic location. This foundational information on keratinocyte carcinoma anatomic locations in the US is valuable for improved keratinocyte risk factor differentiation and skin cancer surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.0611","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T15:01:34Z","timestamp":1681916494000},"page":"643","source":"Crossref","is-referenced-by-count":11,"title":["Anatomic Locations of Procedurally Treated Keratinocyte Carcinomas in the US Medicare Population"],"prefix":"10.1001","volume":"159","author":[{"given":"Lucy J.","family":"Navsaria","sequence":"first","affiliation":[{"name":"Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjna","family":"Tripathy","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madisyn L.","family":"Cox","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice L.","family":"Hinkston","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia"},{"name":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie R.","family":"Wehner","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston"},{"name":"Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"dbr230004r1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jaad.2014.09.036","article-title":"It\u2019s time for \u201ckeratinocyte carcinoma\u201d to replace the term \u201cnonmelanoma skin cancer\u201d.","volume":"72","author":"Karimkhani","year":"2015","journal-title":"J Am Acad 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